scholarly journals Laminin β1a controls distinct steps during the establishment of digestive organ laterality

Development ◽  
2013 ◽  
Vol 140 (13) ◽  
pp. 2734-2745 ◽  
Author(s):  
Tatiana Hochgreb-Hägele ◽  
Chunyue Yin ◽  
Daniel E. S. Koo ◽  
Marianne E. Bronner ◽  
Didier Y. R. Stainier
Keyword(s):  
Digestive Organ ◽  
Organ Laterality

Histochemical and Ultrastructural Studies of the Digestive Epithelium in a Gastropod Gametolytic Organ

1980 ◽  
Vol 38 ◽  
pp. 568-569
Author(s):  
R. L. Reeder ◽  
S. H. Rogers ◽  
W. A. Shannon
Keyword(s):  
Acid Phosphatase ◽  
Genital Tract ◽  
Reproductive Tract ◽  
Ultrastructural Level ◽  
Conclusive Evidence ◽  
Digestive Organ ◽  
Limited Information ◽  
Ultrastructural Studies ◽  
Morphological Studies

Numerous morphological studies have dealt with the spermatheca of pulmonate gastropods. This globular organ, which is attached to the female portion of the reproductive tract by a long duct in these monoecious animals, has had various functions ascribed to it. Recent histochemical demonstrations of deoxyribonuclease, ribonuclease, protease, and acid phosphatase have provided, however, conclusive evidence that it is a digestive organ for the degradation of superfluous sperm and genital tract secretions. Only limited information concerning the spermatheca is available at the ultrastructural level, a fact providing the stimulus for the present study of this organ in Sonorella santaritana, a desert mountain snail from Arizona.

scholarly journals Emerging Genotype-Phenotype Relationships in Primary Ciliary Dyskinesia

2021 ◽  
Vol 22 (15) ◽  
pp. 8272
Author(s):  
Steven K Brennan ◽  
Thomas W Ferkol ◽  
Stephanie D Davis
Keyword(s):  
Primary Ciliary Dyskinesia ◽  
Pulmonary Infections ◽  
Disease Research ◽  
The Past ◽  
Clinical Presentations ◽  
Organ Laterality ◽  
Ciliary Dyskinesia ◽  
Laterality Defects ◽  
Severe Lung Disease ◽  
Severe Lung

Primary ciliary dyskinesia (PCD) is a rare inherited condition affecting motile cilia and leading to organ laterality defects, recurrent sino-pulmonary infections, bronchiectasis, and severe lung disease. Research over the past twenty years has revealed variability in clinical presentations, ranging from mild to more severe phenotypes. Genotype and phenotype relationships have emerged. The increasing availability of genetic panels for PCD continue to redefine these genotype-phenotype relationships and reveal milder forms of disease that had previously gone unrecognized.

Spectroscopic analysis of autofluorescence distribution in digestive organ for unstained metabolism-based tumor detection

2017 ◽  
Author(s):  
Hidenobu Arimoto ◽  
Atsushi Iwata ◽  
Keiichiro Kagawa ◽  
Yoji Sanomura ◽  
Shigeto Yoshida ◽  
...  
Keyword(s):  
Spectroscopic Analysis ◽  
Tumor Detection ◽  
Digestive Organ

Differentiation of allantoic endoderm implanted into the presumptive digestive area in avian embryos. A study with organ-specific antigens

Development ◽  
1984 ◽  
Vol 80 (1) ◽  
pp. 137-153
Author(s):  
Sadao Yasugi
Keyword(s):  
Digestive Tract ◽  
Intestinal Epithelium ◽  
Digestive Organ ◽  
Chick Embryos ◽  
Avian Embryos ◽  
Digestive Organs ◽  
Organ Specific ◽  
Specific Antigens

Quail allantoic endoderm was implanted into the presumptive digestive-tract area of chick embryos, and the differentiation of the endoderm was examined morphologically and immunocytochemically with antisera against pepsinogens and sucrase. The allantoic endoderm was incorporated into the host digestive organs. It often became continuous with the host endoderm and formed a chimaeric digestive-tract epithelium. It differentiated morphologically into the epithelium of the digestive organ into which it was incorporated, showing the morphological inductive ability in situ of the digestive-tract mesenchyme against the allantoic endoderm. However, the allantoic endoderm did not produce pepsinogens even when it was incorporated into the host proventricular mesenchyme and formed well-developed proventricular glands. This result indicates that the heterotypic morphogenesis of the allantoic endoderm is not necessarily accompanied by the heterotypic cytodifferentiation. In contrast, the anti-sucrase antiserum-reactive cells often differentiated in the allantoic endoderm incorporated into not only the intestine but also other organs. This confirmed our previous observation that the allantoic endoderm has a tendency to differentiate into the intestinal epithelium in the heterologous environment.

scholarly journals Clinical Implification of Molecular Biological Parameter for Prognostic Factor in Digestive Organ Cancer.

1993 ◽  
Vol 26 (10) ◽  
pp. 2494-2498
Author(s):  
Masakazu Ueda ◽  
Kiyoshi Kikuchi ◽  
Nobutoshi Ando ◽  
Toshiharu Tsuzuki ◽  
Masaki Kitajima
Keyword(s):  
Prognostic Factor ◽  
Biological Parameter ◽  
Digestive Organ

scholarly journals On the so-called “Liver ”of Carcinus mœnas

1890 ◽  
Vol 16 ◽  
pp. 178-181
Author(s):  
A. B. Griffiths
Keyword(s):  
Digestive Organ ◽  
Comparative Physiology ◽  
Animal Life ◽  
Physiological Functions

This memoir details a continuation of the author's investigations on the physiology of the Invertebrata. At this point we consider the physiological functions of the so-called “liver ” of the Brachyura.Was it not M. Letourneau, in his La Biologie, who said, “Does the pancreas exist in the invertebrates? This is a question of comparative physiology which still waits for a reply. We have seen that we do not begin clearly to recognise the pancreas except in fishes, and then only in a rudimentary state.” From the recent researches of Krukenberg, Frederieq, Jousset de Bellesme, Plateau, Hoppe-Seyler, as well as those of the author, the problem now requiring solution is the following:-Does a true liver exist in the Invertebrata? The pancreas appears to be the chief digestive organ (other than a true stomach) of the earlier forms of animal life.

scholarly journals Clinical and Genetic Analysis of Children with Kartagener Syndrome

Cells ◽  
2019 ◽  
Vol 8 (8) ◽  
pp. 900 ◽  
Author(s):  
Rute Pereira ◽  
Telma Barbosa ◽  
Luís Gales ◽  
Elsa Oliveira ◽  
Rosário Santos ◽  
...  
Keyword(s):  
Autosomal Recessive Disorder ◽  
Kartagener Syndrome ◽  
Mucus Clearance ◽  
Pathogenic Variants ◽  
Transmission Electron ◽  
Whole Exome ◽  
Dynein Arms ◽  
Organ Laterality ◽  
Ciliary Dyskinesia ◽  
Laterality Defects

Primary ciliary dyskinesia (PCD) is a rare autosomal recessive disorder characterized by dysfunction of motile cilia causing ineffective mucus clearance and organ laterality defects. In this study, two unrelated Portuguese children with strong PCD suspicion underwent extensive clinical and genetic assessments by whole-exome sequencing (WES), as well as ultrastructural analysis of cilia by transmission electron microscopy (TEM) to identify their genetic etiology. These analyses confirmed the diagnostic of Kartagener syndrome (KS) (PCD with situs inversus). Patient-1 showed a predominance of the absence of the inner dynein arms with two disease-causing variants in the CCDC40 gene. Patient-2 showed the absence of both dynein arms and WES disclosed two novel high impact variants in the DNAH5 gene and two missense variants in the DNAH7 gene, all possibly deleterious. Moreover, in Patient-2, functional data revealed a reduction of gene expression and protein mislocalization in both genes’ products. Our work calls the researcher’s attention to the complexity of the PCD and to the possibility of gene interactions modelling the PCD phenotype. Further, it is demonstrated that even for well-known PCD genes, novel pathogenic variants could have importance for a PCD/KS diagnosis, reinforcing the difficulty of providing genetic counselling and prenatal diagnosis to families.

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