scholarly journals Pax genes: regulators of lineage specification and progenitor cell maintenance

Development ◽  
2014 ◽  
Vol 141 (4) ◽  
pp. 737-751 ◽  
Author(s):  
J. A. Blake ◽  
M. R. Ziman
Keyword(s):  
Progenitor Cell ◽  
Lineage Specification ◽  
Pax Genes ◽  
Cell Maintenance

scholarly journals The RNA binding protein Swm is critical for Drosophila melanogaster intestinal progenitor cell maintenance

2022 ◽  
Author(s):  
Ishara S Ariyapala ◽  
Kasun Buddika ◽  
Heather A Hundley ◽  
Brian Calvi ◽  
Nicholas Sokol
Keyword(s):  
Stem Cell ◽  
Progenitor Cells ◽  
Progenitor Cell ◽  
Transcriptional Control ◽  
Rna Binding ◽  
Rna Binding Protein ◽  
Adult Stem Cell ◽  
Stem Cell Maintenance ◽  
And Function ◽  
Cell Maintenance

The regulation of stem cell survival, self-renewal, and differentiation is critical for the maintenance of tissue homeostasis. Although the involvement of signaling pathways and transcriptional control mechanisms in stem cell regulation have been extensively investigated, the role of post-transcriptional control is still poorly understood. Here we show that the nuclear activity of the RNA-binding protein Second Mitotic Wave Missing (Swm) is critical for Drosophila intestinal stem cells (ISCs) and their daughter cells, enteroblasts (EBs), to maintain their identity and function. Loss of swm in these intestinal progenitor cells leads ISCs and EBs to lose defined cell identities, fail to proliferate, and detach from the basement membrane, resulting in severe progenitor cell loss. swm loss further causes nuclear accumulation of poly(A)+ RNA in progenitor cells. Swm associates with transcripts involved in epithelial cell maintenance and adhesion, and the loss of swm, while not generally affecting the levels of these Swm-bound mRNAs, leads to elevated expression of proteins encoded by some of them, including the fly orthologs of Filamin and Talin. Taken together, this study indicates a role for Swm in adult stem cell maintenance, and raises the possibility that nuclear post-transcriptional gene regulation plays vital roles in controlling adult stem cell maintenance and function.

scholarly journals CXCR4-Mediated Bone Marrow Progenitor Cell Maintenance and Mobilization Are Modulated by c-kit Activity

2010 ◽  
Vol 107 (9) ◽  
pp. 1083-1093 ◽  
Author(s):  
Min Cheng ◽  
Junlan Zhou ◽  
Min Wu ◽  
Chan Boriboun ◽  
Tina Thorne ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Progenitor Cell ◽  
Bone Marrow Progenitor Cell ◽  
Bone Marrow Progenitor ◽  
Cell Maintenance

scholarly journals Molecular Mechanisms of Stem/Progenitor Cell Maintenance in the Adrenal Cortex

2017 ◽  
Vol 8 ◽  
Author(s):  
Antonio Marcondes Lerario ◽  
Isabella Finco ◽  
Christopher LaPensee ◽  
Gary Douglas Hammer
Keyword(s):  
Adrenal Cortex ◽  
Progenitor Cell ◽  
Molecular Mechanisms ◽  
Cell Maintenance

scholarly journals Lipoprotein lipase regulates hematopoietic stem progenitor cell maintenance through DHA supply

2018 ◽  
Vol 9 (1) ◽  
Author(s):  
Chao Liu ◽  
Tianxu Han ◽  
David L. Stachura ◽  
Huawei Wang ◽  
Boris L. Vaisman ◽  
...  
Keyword(s):  
Lipoprotein Lipase ◽  
Progenitor Cell ◽  
Hematopoietic Stem ◽  
Cell Maintenance

scholarly journals Sonic Hedgehog Is Required for Progenitor Cell Maintenance in Telencephalic Stem Cell Niches

Neuron ◽  
2003 ◽  
Vol 40 (1) ◽  
pp. 189-190 ◽  
Author(s):  
Robert Machold ◽  
Shigemi Hayashi ◽  
Michael Rutlin ◽  
Mandar D Muzumdar ◽  
Susana Nery ◽  
...  
Keyword(s):  
Stem Cell ◽  
Sonic Hedgehog ◽  
Progenitor Cell ◽  
Stem Cell Niches ◽  
Cell Maintenance

scholarly journals The exon junction complex is required for stem and progenitor cell maintenance in planarians

2020 ◽  
Vol 457 (1) ◽  
pp. 119-127 ◽  
Author(s):  
Casey Kimball ◽  
Kaleigh Powers ◽  
John Dustin ◽  
Vanessa Poirier ◽  
Jason Pellettieri
Keyword(s):  
Progenitor Cell ◽  
Exon Junction Complex ◽  
Exon Junction ◽  
Cell Maintenance
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