scholarly journals BEND6 is a nuclear antagonist of Notch signaling during self-renewal of neural stem cells

Development ◽  
2013 ◽  
Vol 140 (9) ◽  
pp. 1892-1902 ◽  
Author(s):  
Q. Dai ◽  
C. Andreu-Agullo ◽  
R. Insolera ◽  
L. C. Wong ◽  
S.-H. Shi ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Notch Signaling ◽  
Self Renewal

NOTCH Signaling Is Essential for Maturation, Self-Renewal, and Tri-Differentiation of In Vitro Derived Human Neural Stem Cells

2017 ◽  
Vol 19 (6) ◽  
pp. 372-383 ◽  
Author(s):  
Katari Venkatesh ◽  
L. Vinod Kumar Reddy ◽  
Salar Abbas ◽  
Madhubanti Mullick ◽  
Erfath Thanjeem Begum Moghal ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Notch Signaling ◽  
Self Renewal ◽  
Human Neural Stem Cells

scholarly journals Mesenchymal stem cells regulate maintenance of neural stem cells through VEGFR2 and Notch signaling pathways

Cell Research ◽  
2008 ◽  
Vol 18 (S1) ◽  
pp. S59-S59
Author(s):  
Zhifeng Deng ◽  
Zhumin Liu ◽  
Wei Tu ◽  
Yang Wang ◽  
Yuanlei Lou
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Neural Stem Cells ◽  
Notch Signaling ◽  
Signaling Pathways

The Balance Between Self-Renewal and Differentiation of Human Neural Stem Cells Requires the Amyloid Precursor Protein

2021 ◽  
Author(s):  
Khadijeh Shabani ◽  
Julien Pigeon ◽  
Marwan Benaissa Touil Zariouh ◽  
Tengyuan Liu ◽  
Azadeh Saffarian ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Amyloid Precursor Protein ◽  
Precursor Protein ◽  
Self Renewal ◽  
Human Neural Stem Cells

scholarly journals Sevoflurane decreases self-renewal capacity and causes c-Jun N-terminal kinase–mediated damage of rat fetal neural stem cells

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Zeyong Yang ◽  
Jingjing Lv ◽  
Xingxing Li ◽  
Qiong Meng ◽  
Qiling Yang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Self Renewal

scholarly journals Cytokines Induce Monkey Neural Stem Cell Differentiation through Notch Signaling

2020 ◽  
Vol 2020 ◽  
pp. 1-13 ◽  
Author(s):  
Min Wang ◽  
Liming Yu ◽  
Lu-Ying Zhu ◽  
Hua He ◽  
Jie Ren ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Neural Stem Cells ◽  
Notch Signaling ◽  
Stem Cell Differentiation ◽  
Leukaemia Inhibitory Factor ◽  
Cytokine Signaling ◽  
Cord Injury ◽  
Theoretical Evidence

The mammalian central nervous system (CNS) has a limited ability to renew the damaged cells after a brain or spinal cord injury whether it is nonhuman primates like monkeys or humans. Transplantation of neural stem cells (NSCs) is a potential therapy for CNS injuries due to their pluripotency and differentiation abilities. Cytokines play an important role in CNS development and repair of CNS injuries. However, the detailed cytokine signaling response in monkey neural stem cells is rarely studied. In our previous research, we isolated NSCs from the adult monkey brain and found the effects of cytokines on monkey NSCs. Now, we further analyzed the regulation mechanisms of cytokines to the proliferation of monkey NSCs such as bone morphogenic protein 4 (BMP4), BMP4/leukaemia inhibitory factor (LIF), or retinoic acid (RA)/Forskolin. The data showed that BMP4 inhibited cell proliferation to arrest, but it did not affect the stemness of NSCs. BMP4/LIF promoted the astrocyte-like differentiation of monkey NSCs, and RA/forskolin induced the neuronal differentiation of monkey NSCs. BMP4/LIF and RA/forskolin induced monkey NSC differentiation by regulating Notch signaling. These results provide some theoretical evidence for NSC therapy to brain or spinal cord injury in regenerative medicine.

Sign in / Sign up

Export Citation Format

Share Document