scholarly journals Fine-tuning of Hh signaling by the RNA-binding protein Quaking to control muscle development

Development ◽  
2011 ◽  
Vol 138 (9) ◽  
pp. 1783-1794 ◽  
Author(s):  
R. Lobbardi ◽  
G. Lambert ◽  
J. Zhao ◽  
R. Geisler ◽  
H. R. Kim ◽  
...  
Keyword(s):  
Muscle Development ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Fine Tuning ◽  
Control Muscle ◽  
Hh Signaling

scholarly journals The RNA-binding protein Mex3b has a fine-tuning system for mRNA regulation in early Xenopus development

Development ◽  
2009 ◽  
Vol 136 (14) ◽  
pp. 2413-2422 ◽  
Author(s):  
H. Takada ◽  
T. Kawana ◽  
Y. Ito ◽  
R. F. Kikuno ◽  
H. Mamada ◽  
...  
Keyword(s):  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Fine Tuning ◽  
Mrna Regulation ◽  
Xenopus Development

scholarly journals Interaction of OIP5-AS1 with MEF2C mRNA promotes myogenic gene expression

2020 ◽  
Vol 48 (22) ◽  
pp. 12943-12956
Author(s):  
Jen-Hao Yang ◽  
Ming-Wen Chang ◽  
Poonam R Pandey ◽  
Dimitrios Tsitsipatis ◽  
Xiaoling Yang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Transcription Factor ◽  
Muscle Regeneration ◽  
Muscle Development ◽  
Rna Binding ◽  
Myogenic Differentiation ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Regulate Gene Expression ◽  
Regulate Gene

Abstract Long noncoding (lnc)RNAs potently regulate gene expression programs in physiology and disease. Here, we describe a key function for lncRNA OIP5-AS1 in myogenesis, the process whereby myoblasts differentiate into myotubes during muscle development and muscle regeneration after injury. In human myoblasts, OIP5-AS1 levels increased robustly early in myogenesis, and its loss attenuated myogenic differentiation and potently reduced the levels of the myogenic transcription factor MEF2C. This effect relied upon the partial complementarity of OIP5-AS1 with MEF2C mRNA and the presence of HuR, an RNA-binding protein (RBP) with affinity for both transcripts. Remarkably, HuR binding to MEF2C mRNA, which stabilized MEF2C mRNA and increased MEF2C abundance, was lost after OIP5-AS1 silencing, suggesting that OIP5-AS1 might serve as a scaffold to enhance HuR binding to MEF2C mRNA, in turn increasing MEF2C production. These results highlight a mechanism whereby a lncRNA promotes myogenesis by enhancing the interaction of an RBP and a myogenic mRNA.

235: The RNA-Binding Protein IMP3: A Novel Molecular Marker Predicts Progression of Superficial (TA and T1) Urothelial Carcinomas of Bladder

2007 ◽  
Vol 177 (4S) ◽  
pp. 78-79
Author(s):  
Lioudmila Sitnikova ◽  
Gary Mendese ◽  
Qin Lui ◽  
Bruce A. Woda ◽  
Di Lu ◽  
...  
Keyword(s):  
Molecular Marker ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Urothelial Carcinomas
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