scholarly journals Macrophages define dermal lymphatic vessel calibre during development by regulating lymphatic endothelial cell proliferation

Development ◽  
2010 ◽  
Vol 137 (22) ◽  
pp. 3899-3910 ◽  
Author(s):  
E. J. Gordon ◽  
S. Rao ◽  
J. W. Pollard ◽  
S. L. Nutt ◽  
R. A. Lang ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Endothelial Cell ◽  
Lymphatic Vessel ◽  
Lymphatic Endothelial Cell ◽  
Endothelial Cell Proliferation

scholarly journals Macrophages define dermal lymphatic vessel calibre during development by regulating lymphatic endothelial cell proliferation

Development ◽  
2011 ◽  
Vol 138 (4) ◽  
pp. 797-797
Author(s):  
E. J. Gordon ◽  
S. Rao ◽  
J. W. Pollard ◽  
S. L. Nutt ◽  
R. A. Lang ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Endothelial Cell ◽  
Lymphatic Vessel ◽  
Lymphatic Endothelial Cell ◽  
Endothelial Cell Proliferation

Macrophages define dermal lymphatic vessel calibre during development by regulating lymphatic endothelial cell proliferation.

2010 ◽  
Vol 123 (22) ◽  
pp. e1-e1
Author(s):  
E. J. Gordon ◽  
S. Rao ◽  
J. W. Pollard ◽  
S. L. Nutt ◽  
R. A. Lang ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Endothelial Cell ◽  
Lymphatic Vessel ◽  
Lymphatic Endothelial Cell ◽  
Endothelial Cell Proliferation

scholarly journals Sonic hedgehog selectively promotes lymphangiogenesis after kidney injury through noncanonical pathway

2019 ◽  
Vol 317 (4) ◽  
pp. F1022-F1033 ◽  
Author(s):  
Hui Zhuo ◽  
Dong Zhou ◽  
Yuanyuan Wang ◽  
Hongyan Mo ◽  
Ying Yu ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Endothelial Cells ◽  
Endothelial Cell ◽  
Sonic Hedgehog ◽  
Lymphatic Vessels ◽  
Kidney Injury ◽  
Lymphatic Endothelial Cell ◽  
Cell Counting ◽  
Endothelial Cell Proliferation ◽  
Vascular Endothelial

Kidney fibrosis is associated with an increased lymphangiogenesis, characterized by the formation and expansion of new lymphatic vessels. However, the trigger and underlying mechanism responsible for the growth of lymphatic vessels in diseased kidney remain poorly defined. Here, we report that tubule-derived sonic hedgehog (Shh) ligand is a novel lymphangiogenic factor that plays a crucial role in mediating lymphatic endothelial cell proliferation and expansion. Shh was induced in renal tubular epithelium in various models of fibrotic chronic kidney disease, and this was accompanied by an expansion of lymphatic vessels in adjacent areas. In vitro, Shh selectively promoted the proliferation of human dermal lymphatic endothelial cells (HDLECs) but not human umbilical vein endothelial cells, as assessed by cell counting, MTT assay, and bromodeoxyuridine incorporation. Shh also induced the expression of vascular endothelial growth factor receptor-3, cyclin D1, and proliferating cell nuclear antigen in HDLECs. Shh did not affect the expression of Gli1, the downstream target and readout of canonical hedgehog signaling, but activated ERK-1/2 in HDLECs. Inhibition of Smoothened with small-molecule inhibitor or blockade of ERK-1/2 activation abolished the lymphatic endothelial cell proliferation induced by Shh. In vivo, inhibition of Smoothened also repressed lymphangiogenesis and attenuated renal fibrosis. This study identifies Shh as a novel mitogen that selectively promotes lymphatic, but not vascular, endothelial cell proliferation and suggests that tubule-derived Shh plays an essential role in mediating lymphangiogenesis after kidney injury.

scholarly journals IL-27 Inhibits Lymphatic Endothelial Cell Proliferation by STAT1-Regulated Gene Expression

2013 ◽  
Vol 20 (6) ◽  
pp. 555-564 ◽  
Author(s):  
Sebastian Rune Nielsen ◽  
Troels Hammer ◽  
Josefine Gibson ◽  
Michael S. Pepper ◽  
Riccardo E. Nisato ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Proliferation ◽  
Endothelial Cell ◽  
Lymphatic Endothelial Cell ◽  
Endothelial Cell Proliferation ◽  
Regulated Gene Expression

scholarly journals Lymphotoxins Promote the Progression of Human Lymphatic Malformation by Enhancing Lymphatic Endothelial Cell Proliferation

2017 ◽  
Vol 187 (11) ◽  
pp. 2602-2615 ◽  
Author(s):  
Jie-Gang Yang ◽  
Yan-Fang Sun ◽  
Ke-Fei He ◽  
Jian-Gang Ren ◽  
Zhuo-Jue Liu ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Endothelial Cell ◽  
Lymphatic Endothelial Cell ◽  
Lymphatic Malformation ◽  
Endothelial Cell Proliferation
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