scholarly journals Dampened Hedgehog signaling but normal Wnt signaling in zebrafish without cilia

Development ◽  
2009 ◽  
Vol 136 (18) ◽  
pp. 3089-3098 ◽  
Author(s):  
P. Huang ◽  
A. F. Schier
Keyword(s):  
Wnt Signaling ◽  
Hedgehog Signaling

Cleft Palate and Aglossia Result from Perturbations in Wnt and Hedgehog Signaling

2017 ◽  
Vol 54 (3) ◽  
pp. 269-280 ◽  
Author(s):  
Gongjie Yuan ◽  
Gurpreet Singh ◽  
Serafine Chen ◽  
Kristy Carrington Perez ◽  
Yan Wu ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Wnt Signaling ◽  
Primary Cilium ◽  
Molecular Basis ◽  
Hedgehog Signaling ◽  
Intraflagellar Transport ◽  
Molecular Signaling ◽  
A Cell ◽  
Cranial Neural Crest Cells ◽  
Facial Development

Objective The objective of this study was to explore the molecular basis for cleft secondary palate and arrested tongue development caused by the loss of the intraflagellar transport protein, Kif3a. Design Kif3a mutant embryos and their littermate controls were analyzed for defects in facial development at multiple stages of embryonic development. Histology was employed to understand the effects of Kif3a deletion on palate and tongue development. Various transgenic reporter strains were used to understand how deletion of Kif3a affected Hedgehog and Wnt signaling. Immunostaining for structural elements of the tongue and for components of the Wnt pathway were performed. BrdU activity analyses were carried out to examine how the loss of Kif3a affected cell proliferation and led to palate and tongue malformations. Results Kif3a deletion causes cranial neural crest cells to become unresponsive to Hedgehog signals and hyper-responsive to Wnt signals. This aberrant molecular signaling causes abnormally high cell proliferation, but paradoxically outgrowths of the tongue and the palatal processes are reduced. The basis for this enigmatic effect can be traced back to a disruption in epithelial/mesenchymal signaling that governs facial development. Conclusion The primary cilium is a cell surface organelle that integrates Hh and Wnt signaling, and disruptions in the function of the primary cilium cause one of the most common—of the rarest—craniofacial birth defects observed in humans. The shared molecular basis for these dysmorphologies is an abnormally high Wnt signal simultaneous with an abnormally low Hedgehog signal. These pathways are integrated in the primary cilium.

scholarly journals Targeting Wnt Signaling in Endometrial Cancer

Cancers ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 2351
Author(s):  
Iram Fatima ◽  
Susmita Barman ◽  
Rajani Rai ◽  
Kristina W. Thiel ◽  
Vishal Chandra
Keyword(s):  
Endometrial Cancer ◽  
Wnt Signaling ◽  
Hedgehog Signaling ◽  
Breast Cancers ◽  
Genetic Studies ◽  
Wnt Proteins ◽  
New Findings ◽  
Endometrial Carcinomas ◽  
Cycle Regulation

This review presents new findings on Wnt signaling in endometrial carcinoma and implications for possible future treatments. The Wnt proteins are essential mediators in cell signaling during vertebrate embryo development. Recent biochemical and genetic studies have provided significant insight into Wnt signaling, in particular in cell cycle regulation, inflammation, and cancer. The role of Wnt signaling is well established in gastrointestinal and breast cancers, but its function in gynecologic cancers, especially in endometrial cancers, has not been well elucidated. Development of a subset of endometrial carcinomas has been attributed to activation of the APC/β-catenin signaling pathway (due to β-catenin mutations) and downregulation of Wnt antagonists by epigenetic silencing. The Wnt pathway also appears to be linked to estrogen and progesterone, and new findings implicate it in mTOR and Hedgehog signaling. Therapeutic interference of Wnt signaling remains a significant challenge. Herein, we discuss the Wnt-activating mechanisms in endometrial cancer and review the current advances and challenges in drug discovery.

scholarly journals Six3 cooperates with Hedgehog signaling to specify ventral telencephalon by promoting early expression of Foxg1a and repressing Wnt signaling

Development ◽  
2012 ◽  
Vol 139 (14) ◽  
pp. 2614-2624 ◽  
Author(s):  
D. Carlin ◽  
D. Sepich ◽  
V. K. Grover ◽  
M. K. Cooper ◽  
L. Solnica-Krezel ◽  
...  
Keyword(s):  
Wnt Signaling ◽  
Hedgehog Signaling ◽  
Ventral Telencephalon ◽  
Early Expression

Wnt signaling pathway regulates the differentiation of hepatic progenitor cells

2010 ◽  
Vol 34 (8) ◽  
pp. S41-S41
Author(s):  
Yang Bi ◽  
Yun He ◽  
Tingyu Li ◽  
Tao Feng ◽  
Tongchuan He
Keyword(s):  
Wnt Signaling ◽  
Progenitor Cells ◽  
Signaling Pathway ◽  
Wnt Signaling Pathway ◽  
Hepatic Progenitor Cells

417: The Human Androgen Receptor Gene is a Primary Target of the WNT Signaling Pathway

2006 ◽  
Vol 175 (4S) ◽  
pp. 136-136
Author(s):  
Ralph Buttyan ◽  
Xuezhen Yang ◽  
Min-Wei Chen ◽  
Debra L. Bemis ◽  
Mitchell C. Benson ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Wnt Signaling ◽  
Signaling Pathway ◽  
Receptor Gene ◽  
Wnt Signaling Pathway ◽  
Androgen Receptor Gene ◽  
Primary Target ◽  
Human Androgen Receptor Gene ◽  
Human Androgen Receptor
Sign in / Sign up

Export Citation Format

Share Document