scholarly journals G protein-coupled receptor 48 upregulates estrogen receptor   expression via cAMP/PKA signaling in the male reproductive tract

Development ◽  
2009 ◽  
Vol 137 (1) ◽  
pp. 151-157 ◽  
Author(s):  
X.-Y. Li ◽  
Y. Lu ◽  
H.-Y. Sun ◽  
J.-Q. Wang ◽  
J. Yang ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
G Protein ◽  
Reproductive Tract ◽  
Receptor Expression ◽  
Estrogen Receptor Expression ◽  
G Protein Coupled Receptor ◽  
Male Reproductive Tract ◽  
G Protein Coupled

scholarly journals Stroke Increases G Protein-Coupled Estrogen Receptor Expression in the Brain of Male but Not Female Mice

Neurosignals ◽  
2013 ◽  
Vol 21 (3-4) ◽  
pp. 229-239 ◽  
Author(s):  
Brad R.S. Broughton ◽  
Vanessa H. Brait ◽  
Elizabeth Guida ◽  
Seyoung Lee ◽  
Thiruma V. Arumugam ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
G Protein ◽  
Receptor Expression ◽  
Estrogen Receptor Expression ◽  
Female Mice ◽  
G Protein Coupled ◽  
The Brain

scholarly journals Anatomical Profiling of G Protein-Coupled Receptor Expression

Cell ◽  
2008 ◽  
Vol 135 (3) ◽  
pp. 561-571 ◽  
Author(s):  
Jean B. Regard ◽  
Isaac T. Sato ◽  
Shaun R. Coughlin
Keyword(s):  
G Protein ◽  
Receptor Expression ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

G protein-coupled receptor expression in Halobacterium salinarum

2001 ◽  
pp. 141-159 ◽  
Author(s):  
Ann M. Winter-Vann ◽  
Lynell Martinez ◽  
Cynthia Bartus ◽  
Agata Levay ◽  
George J. Turner
Keyword(s):  
G Protein ◽  
Halobacterium Salinarum ◽  
Receptor Expression ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

G-protein Coupled Estrogen Receptor Expression in Growth Hormone Secreting and Non-Functioning Adenomas

2020 ◽  
Author(s):  
Hande Mefkure Ozkaya ◽  
Muge Sayitoglu ◽  
Nil Comunoglu ◽  
Eda Sun ◽  
Fatma Ela Keskin ◽  
...  
Keyword(s):  
Gene Expression ◽  
Estrogen Receptor ◽  
Protein Expression ◽  
G Protein ◽  
Estrogen Receptor Α ◽  
Receptor Expression ◽  
Positive Correlation ◽  
Polymerase Chain ◽  
G Protein Coupled ◽  
Transforming Gene

Abstract Purpose To evaluate the expression of G-protein coupled estrogen receptor (GPER1), aromatase, estrogen receptor α (ERα), estrogen receptor β (ERβ), pituitary tumor transforming gene (PTTG), and fibroblast growth factor 2 (FGF2) in GH-secreting and non-functioning adenomas (NFA). Methods Thirty patients with acromegaly and 27 patients with NFA were included. Gene expression was determined via quantitative reverse transcription polymerase chain reaction (QRT-PCR). Protein expression was determined via immunohistochemistry. Results There was no difference, in terms of gene expression of aromatase, ERα, PTTG, and FGF2 between the two groups (p>0.05 for all). ERβ gene expression was higher and GPER1 gene expression was lower in GH-secreting adenomas than NFAs (p<0.05 for all). Aromatase and ERβ protein expression was higher in GH-secreting adenomas than NFAs (p=0.01). None of the tumors expressed ERα. GPER1 expression was detected in 62.2% of the GH-secreting adenomas and 45% of NFAs. There was no difference in terms of GPER1, PTTG, FGF2 H scores between the two groups (p>0.05 for all). GPER1 gene expression was positively correlated to ERα, ERβ, PTTG, and FGF2 gene expression (p<0.05 for all). There was a positive correlation between aromatase and GPER1 protein expression (r=0.31; p=0.04). Conclusions GPER1 is expressed at both gene and protein level in a substantial portion of GH-secreting adenomas and NFAs. The finding of a positive correlation between GPER1 and ERα, ERβ, PTTG, and FGF2 gene expression and aromatase and GPER1 protein expression suggests GPER1 along with aromatase and classical ERs might mediate the effects of estrogen through upregulation of PTTG and FGF2.

scholarly journals Activation of Estrogen Receptor G Protein–Coupled Receptor 30 Enhances Cholesterol Cholelithogenesis in Female Mice

Hepatology ◽  
2020 ◽  
Vol 72 (6) ◽  
pp. 2077-2089 ◽  
Author(s):  
Helen H. Wang ◽  
Ornella Bari ◽  
Christopher K. Arnatt ◽  
Min Liu ◽  
Piero Portincasa ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
G Protein ◽  
G Protein Coupled Receptor ◽  
Female Mice ◽  
G Protein Coupled
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