scholarly journals Chondroitin sulfate glycosaminoglycans control proliferation, radial glia cell differentiation and neurogenesis in neural stem/progenitor cells

Development ◽  
2007 ◽  
Vol 134 (15) ◽  
pp. 2727-2738 ◽  
Author(s):  
S. Sirko ◽  
A. von Holst ◽  
A. Wizenmann ◽  
M. Gotz ◽  
A. Faissner
Keyword(s):  
Cell Differentiation ◽  
Chondroitin Sulfate ◽  
Progenitor Cells ◽  
Radial Glia ◽  
Glia Cell ◽  
Neural Stem Progenitor Cells

The capacity to remove 8-oxoG is enhanced in newborn neural stem/progenitor cells and decreases in juvenile mice and upon cell differentiation

DNA Repair ◽  
2007 ◽  
Vol 6 (6) ◽  
pp. 723-732 ◽  
Author(s):  
Gunn A. Hildrestrand ◽  
Dzung B. Diep ◽  
David Kunke ◽  
Nils Bolstad ◽  
Magnar Bjørås ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Progenitor Cells ◽  
Neural Stem Progenitor Cells

scholarly journals Extracellular Vesicle-Induced Differentiation of Neural Stem Progenitor Cells

2019 ◽  
Vol 20 (15) ◽  
pp. 3691 ◽  
Author(s):  
Eleonora Stronati ◽  
Roberta Conti ◽  
Emanuele Cacci ◽  
Silvia Cardarelli ◽  
Stefano Biagioni ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Progenitor Cells ◽  
Extracellular Vesicles ◽  
Peripheral Nerve Regeneration ◽  
Genetic Material ◽  
Cell Communication ◽  
Synaptic Activity ◽  
Dependent Manner ◽  
Neuronal Marker ◽  
Neural Stem Progenitor Cells

Neural stem progenitor cells (NSPCs) from E13.5 mouse embryos can be maintained in culture under proliferating conditions. Upon growth-factor removal, they may differentiate toward either neuronal or glial phenotypes or both. Exosomes are small extracellular vesicles that are part of the cell secretome; they may contain and deliver both proteins and genetic material and thus play a role in cell–cell communication, guide axonal growth, modulate synaptic activity and regulate peripheral nerve regeneration. In this work, we were interested in determining whether NSPCs and their progeny can produce and secrete extracellular vesicles (EVs) and if their content can affect cell differentiation. Our results indicate that cultured NSPCs produce and secrete EVs both under proliferating conditions and after differentiation. Treatment of proliferating NSPCs with EVs derived from differentiated NSPCs triggers cell differentiation in a dose-dependent manner, as demonstrated by glial- and neuronal-marker expression.

Early proliferative response of radial glia-like progenitor cells in the dentate gyrus following focal ischemia

2005 ◽  
Vol 32 (S 4) ◽  
Author(s):  
A Kunze ◽  
S Grass ◽  
O.W Witte ◽  
G Kempermann ◽  
C Redecker
Keyword(s):  
Dentate Gyrus ◽  
Progenitor Cells ◽  
Proliferative Response ◽  
Radial Glia ◽  
Focal Ischemia
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