scholarly journals Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning

Development ◽  
2005 ◽  
Vol 132 (24) ◽  
pp. 5601-5611 ◽  
Author(s):  
L. Ma
Keyword(s):  
Epithelial Mesenchymal Transition ◽  
Mesenchymal Transition ◽  
Cardiac Cushion

scholarly journals Slug is a direct Notch target required for initiation of cardiac cushion cellularization

2008 ◽  
Vol 182 (2) ◽  
pp. 315-325 ◽  
Author(s):  
Kyle Niessen ◽  
YangXin Fu ◽  
Linda Chang ◽  
Pamela A. Hoodless ◽  
Deborah McFadden ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Transforming Growth Factor ◽  
Epithelial Mesenchymal Transition ◽  
Transforming Growth Factor Β ◽  
Atrioventricular Canal ◽  
Mesenchymal Transition ◽  
Slug Expression ◽  
Snail Family ◽  
Cardiac Cushion ◽  
Endothelial To Mesenchymal Transition

Snail family proteins are key regulators of epithelial-mesenchymal transition, but their role in endothelial-to-mesenchymal transition (EMT) is less well studied. We show that Slug, a Snail family member, is expressed by a subset of endothelial cells as well as mesenchymal cells of the atrioventricular canal and outflow tract during cardiac cushion morphogenesis. Slug deficiency results in impaired cellularization of the cardiac cushion at embryonic day (E)–9.5 but is compensated by increased Snail expression at E10.5, which restores cardiac cushion EMT. We further demonstrate that Slug, but not Snail, is directly up-regulated by Notch in endothelial cells and that Slug expression is required for Notch-mediated repression of the vascular endothelial cadherin promoter and for promoting migration of transformed endothelial cells. In contrast, transforming growth factor β (TGF-β) induces Snail but not Slug. Interestingly, activation of Notch in the context of TGF-β stimulation results in synergistic up-regulation of Snail in endothelial cells. Collectively, our data suggest that combined expression of Slug and Snail is required for EMT in cardiac cushion morphogenesis.

Epithelial mesenchymal transition, stromal density, and chemo-resistance in breast cancer (BrCa)

2019 ◽  
Author(s):  
Andrew Redfern ◽  
Veenoo Agarwal ◽  
Lisa Spalding ◽  
Tony Blick ◽  
Alexander Dobrovic ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Epithelial Mesenchymal Transition ◽  
Mesenchymal Transition
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