scholarly journals Embryonic requirements for ErbB signaling in neural crest development and adult pigment pattern formation

Development ◽  
2008 ◽  
Vol 135 (15) ◽  
pp. 2603-2614 ◽  
Author(s):  
E. H. Budi ◽  
L. B. Patterson ◽  
D. M. Parichy
Keyword(s):  
Pattern Formation ◽  
Neural Crest ◽  
Pigment Pattern ◽  
Neural Crest Development ◽  
Erbb Signaling

Mechanisms of pigment pattern formation in the quail embryo

Development ◽  
1990 ◽  
Vol 109 (1) ◽  
pp. 81-89 ◽  
Author(s):  
M.K. Richardson ◽  
A. Hornbruch ◽  
L. Wolpert
Keyword(s):  
Pattern Formation ◽  
Neural Crest ◽  
Larval Fish ◽  
Dorsal Surface ◽  
Neural Crest Cells ◽  
Mirror Image ◽  
Differential Migration ◽  
Pigment Pattern ◽  
Pigment Patterns ◽  
Local Cues

One hypothesis to account for pigment patterning in birds is that neural crest cells migrate into all feather papillae. Local cues then act upon the differentiation of crest cells into melanocytes. This hypothesis is derived from a study of the quail-chick chimaera (Richardson et al., Development 107, 805–818, 1989). Another idea, derived from work on larval fish and amphibia, is that pigment patterns arise from the differential migration of crest cells. We want to know which of these mechanisms can best account for pigment pattern formation in the embryonic plumage of the quail wing. Most of the feather papillae on the dorsal surface of the wing are pigmented, while many on the ventral surface are white. When ectoderm from unpigmented feather papillae is grown in culture, it gives rise to melanocytes. This indicates that neural crest cells are present in white feathers but that they fail to differentiate. If the wing tip is inverted experimentally then the pigment pattern is inverted also. This is difficult to explain in terms of a model based on migratory pathways, unless one assumes that the pathways became re-routed. When an extra polarizing region is grafted to the anterior margin of the wing bud, a duplication develops in: (1) the pattern of skeletal elements; (2) the pattern of feather papillae; (3) the feather pigment pattern. The pigment pattern was not a precise mirror image although some groups of papillae showed a high degree of symmetry in their pigmentation. Both the tip inversions and the duplications produce discontinuities in the feather and pigment patterns. No evidence of intercalation was found in these cases. We conclude that pigment patterning in birds is determined by local cues acting on melanocyte differentiation, rather than by the differential migration of crest cells. Positional values along the anteroposterior axis of the pigment pattern are determined by a gradient of positional information. Thus the pigment patterns, feather patterns and cartilage patterns of the wing may all be specified by a similar mechanism.

Zebrafish pigmentation mutations and the processes of neural crest development

Development ◽  
1996 ◽  
Vol 123 (1) ◽  
pp. 369-389 ◽  
Author(s):  
R.N. Kelsh ◽  
M. Brand ◽  
Y.J. Jiang ◽  
C.P. Heisenberg ◽  
S. Lin ◽  
...  
Keyword(s):  
Neural Crest ◽  
Cell Fate ◽  
Large Scale ◽  
Pigment Cell ◽  
Cell Fate Specification ◽  
Cell Specification ◽  
Pigment Pattern ◽  
Mutagenesis Screen ◽  
Neural Crest Development

Neural crest development involves cell-fate specification, proliferation, patterned cell migration, survival and differentiation. Zebrafish neural crest derivatives include three distinct chromatophores, which are well-suited to genetic analysis of their development. As part of a large-scale mutagenesis screen for embryonic/early larval mutations, we have isolated 285 mutations affecting all aspects of zebrafish larval pigmentation. By complementation analysis, we define 94 genes. We show here that comparison of their phenotypes permits classification of these mutations according to the types of defects they cause, and these suggest which process of neural crest development is probably affected. Mutations in eight genes affect the number of chromatophores: these include strong candidates for genes necessary for the processes of pigment cell specification and proliferation. Mutations in five genes remove part of the wild-type pigment pattern, and suggest a role in larval pigment pattern formation. Mutations in five genes show ectopic chromatophores in distinct sites, and may have implications for chromatophore patterning and proliferation. 76 genes affect pigment or morphology of one or more chromatophore types: these mutations include strong candidates for genes important in various aspects of chromatophore differentiation and survival. In combination with the embryological advantages of zebrafish, these mutations should permit cellular and molecular dissection of many aspects of neural crest development.

scholarly journals The methyltransferase NSD3 regulates neural crest development

2011 ◽  
Vol 356 (1) ◽  
pp. 196
Author(s):  
Bridget Jacques-Fricke ◽  
Laura S. Gammill
Keyword(s):  
Neural Crest ◽  
Neural Crest Development

Zika virus induces abnormal cranial osteogenesis by negatively affecting cranial neural crest development

2019 ◽  
Vol 69 ◽  
pp. 176-189 ◽  
Author(s):  
Yuqi Yan ◽  
Xiao-tan Zhang ◽  
Guang Wang ◽  
Xin Cheng ◽  
Yu Yan ◽  
...  
Keyword(s):  
Neural Crest ◽  
Zika Virus ◽  
Cranial Neural Crest ◽  
Neural Crest Development

scholarly journals Xenopus Nkx6.3 Is a Neural Plate Border Specifier Required for Neural Crest Development

PLoS ONE ◽  
2014 ◽  
Vol 9 (12) ◽  
pp. e115165 ◽  
Author(s):  
Zuming Zhang ◽  
Yu Shi ◽  
Shuhua Zhao ◽  
Jiejing Li ◽  
Chaocui Li ◽  
...  
Keyword(s):  
Neural Crest ◽  
Neural Plate ◽  
Neural Crest Development ◽  
Neural Plate Border

scholarly journals Bimodal function of chromatin remodeler Hmga1 in neural crest induction and Wnt-dependent emigration

eLife ◽  
2020 ◽  
Vol 9 ◽  
Author(s):  
Shashank Gandhi ◽  
Erica J Hutchins ◽  
Krystyna Maruszko ◽  
Jong H Park ◽  
Matthew Thomson ◽  
...  
Keyword(s):  
Neural Crest ◽  
Neural Tube ◽  
Neural Crest Cells ◽  
Neural Plate ◽  
Chromatin Remodeler ◽  
Lineage Specification ◽  
Dorsal Neural Tube ◽  
Neural Crest Development ◽  
Neural Plate Border ◽  
Canonical Wnt

During gastrulation, neural crest cells are specified at the neural plate border, as characterized by Pax7 expression. Using single-cell RNA sequencing coupled with high-resolution in situ hybridization to identify novel transcriptional regulators, we show that chromatin remodeler Hmga1 is highly expressed prior to specification and maintained in migrating chick neural crest cells. Temporally controlled CRISPR-Cas9-mediated knockouts uncovered two distinct functions of Hmga1 in neural crest development. At the neural plate border, Hmga1 regulates Pax7-dependent neural crest lineage specification. At premigratory stages, a second role manifests where Hmga1 loss reduces cranial crest emigration from the dorsal neural tube independent of Pax7. Interestingly, this is rescued by stabilized ß-catenin, thus implicating Hmga1 as a canonical Wnt activator. Together, our results show that Hmga1 functions in a bimodal manner during neural crest development to regulate specification at the neural plate border, and subsequent emigration from the neural tube via canonical Wnt signaling.

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