Retinoic acid regulates postnatal neurogenesis in the murine subventricular zone-olfactory bulb pathway

Development ◽  
2005 ◽  
Vol 132 (12) ◽  
pp. 2721-2732 ◽  
Author(s):  
T.-W. Wang
Keyword(s):  
Retinoic Acid ◽  
Olfactory Bulb ◽  
Subventricular Zone ◽  
Postnatal Neurogenesis

scholarly journals Multifaceted actions of Zeb2 in postnatal neurogenesis from the ventricular-subventricular zone to the olfactory bulb

Development ◽  
2020 ◽  
Vol 147 (10) ◽  
pp. dev184861
Author(s):  
Astrid Deryckere ◽  
Elke Stappers ◽  
Ruben Dries ◽  
Elise Peyre ◽  
Veronique van den Berghe ◽  
...  
Keyword(s):  
Olfactory Bulb ◽  
Subventricular Zone ◽  
Postnatal Neurogenesis

scholarly journals The Subventricular Zone in the Immature Piglet Brain: Anatomy and Exodus of Neuroblasts into White Matter after Traumatic Brain Injury

2015 ◽  
Vol 37 (2) ◽  
pp. 115-130 ◽  
Author(s):  
Beth A. Costine ◽  
Symeon Missios ◽  
Sabrina R. Taylor ◽  
Declan McGuone ◽  
Colin M. Smith ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
White Matter ◽  
Subventricular Zone ◽  
Mesh Network ◽  
Human Infant ◽  
Ependymal Cells ◽  
Postnatal Neurogenesis ◽  
White Matter Tracts ◽  
Stimulation Of

Stimulation of postnatal neurogenesis in the subventricular zone (SVZ) and robust migration of neuroblasts to the lesion site in response to traumatic brain injury (TBI) is well established in rodent species; however, it is not yet known whether postnatal neurogenesis plays a role in repair after TBI in gyrencephalic species. Here we describe the anatomy of the SVZ in the piglet for the first time and initiate an investigation into the effect of TBI on the SVZ architecture and the number of neuroblasts in the white matter. Among all ages of immaturity examined the SVZ contained a dense mesh network of neurogenic precursor cells (doublecortin+) positioned directly adjacent to the ependymal cells (ventricular SVZ, Vsvz) and neuroblasts organized into chains that were distinct from the Vsvz (abventricular SVZ, Asvz). Though the architecture of the SVZ was similar among ages, the areas of Vsvz and Asvz neuroblast chains declined with age. At postnatal day (PND) 14 the white matter tracts have a tremendous number of individual neuroblasts. In our scaled cortical impact model, lesion size increased with age. Similarly, the response of the SVZ to injury was also age dependent. The younger age groups that sustained the proportionately smallest lesions had the largest SVZ areas, which further increased in response to injury. In piglets that were injured at 4 months of age and had the largest lesions, the SVZ did not increase in response to injury. Similar to humans, swine have abundant gyri and gyral white matter, providing a unique platform to study neuroblasts potentially migrating from the SVZ to the lesioned cortex along these white matter tracts. In piglets injured at PND 7, TBI did not increase the total number of neuroblasts in the white matter compared to uninjured piglets, but redistribution occurred with a greater number of neuroblasts in the white matter of the hemisphere ipsilateral to the injury compared to the contralateral hemisphere. At 7 days after injury, less than 1% of neuroblasts in the white matter were born in the 2 days following injury. These data show that the SVZ in the piglet shares many anatomical similarities with the SVZ in the human infant, and that TBI had only modest effects on the SVZ and the number of neuroblasts in the white matter. Piglets at an equivalent developmental stage to human infants were equipped with the largest SVZ and a tremendous number of neuroblasts in the white matter, which may be sufficient in lesion repair without the dramatic stimulation of neurogenic machinery. It has yet to be determined whether neurogenesis and migrating neuroblasts play a role in repair after TBI and/or whether an alteration of normal migration during active postnatal population of brain regions is beneficial in species with gyrencephalic brains.

scholarly journals Continuous Postnatal Neurogenesis Contributes to Formation of the Olfactory Bulb Neural Circuits and Flexible Olfactory Associative Learning

2014 ◽  
Vol 34 (17) ◽  
pp. 5788-5799 ◽  
Author(s):  
M. Sakamoto ◽  
N. Ieki ◽  
G. Miyoshi ◽  
D. Mochimaru ◽  
H. Miyachi ◽  
...  
Keyword(s):  
Olfactory Bulb ◽  
Associative Learning ◽  
Neural Circuits ◽  
Postnatal Neurogenesis

Spatiotemporal selectivity of response to Notch1 signals in mammalian forebrain precursors

Development ◽  
2001 ◽  
Vol 128 (5) ◽  
pp. 689-702 ◽  
Author(s):  
C.B. Chambers ◽  
Y. Peng ◽  
H. Nguyen ◽  
N. Gaiano ◽  
G. Fishell ◽  
...  
Keyword(s):  
Olfactory Bulb ◽  
Cell Fate ◽  
Subventricular Zone ◽  
Cellular Proliferation ◽  
Precursor Cells ◽  
Temporal Cues ◽  
Short And Long Term ◽  
Cortical Regions ◽  
Anterior Subventricular Zone

The olfactory bulb, neocortex and archicortex arise from a common pool of progenitors in the dorsal telencephalon. We studied the consequences of supplying excess Notch1 signal in vivo on the cellular and regional destinies of telencephalic precursors using bicistronic replication defective retroviruses. After ventricular injections mid-neurogenesis (E14.5), activated Notch1 retrovirus markedly inhibited the generation of neurons from telencephalic precursors, delayed the emergence of cells from the subventricular zone (SVZ), and produced an augmentation of glial progeny in the neo- and archicortex. However, activated Notch1 had a distinct effect on the progenitors of the olfactory bulb, markedly reducing the numbers of cells of any type that migrated there. To elucidate the mechanism of the cell fate changes elicited by Notch1 signals in the cortical regions, short- and long-term cultures of E14.5 telencephalic progenitors were examined. These studies reveal that activated Notch1 elicits a cessation of proliferation that coincides with an inhibition of the generation of neurons. Later, during gliogenesis, activated Notch1 triggers a rapid cellular proliferation with a significant increase in the generation of cells expressing GFAP. To examine the generation of cells destined for the olfactory bulb, we used stereotaxic injections into the early postnatal anterior subventricular zone (SVZa). We observed that precursors of the olfactory bulb responded to Notch signals by remaining quiescent and failing to give rise to differentiated progeny of any type, unlike cortical precursor cells, which generated glia instead of neurons. These data show that forebrain precursors vary in their response to Notch signals according to spatial and temporal cues, and that Notch signals influence the composition of forebrain regions by modulating the rate of proliferation of neural precursor cells.

scholarly journals IGF-I promotes neuronal migration and positioning in the olfactory bulb and the exit of neuroblasts from the subventricular zone

2009 ◽  
Vol 30 (5) ◽  
pp. 742-755 ◽  
Author(s):  
Anahí Hurtado-Chong ◽  
María J. Yusta-Boyo ◽  
Eva Vergaño-Vera ◽  
Alessandro Bulfone ◽  
Flora de Pablo ◽  
...  
Keyword(s):  
Olfactory Bulb ◽  
Subventricular Zone ◽  
Neuronal Migration ◽  
Igf I
Sign in / Sign up

Export Citation Format

Share Document