scholarly journals GDF11 modulates NGN3+ islet progenitor cell number and promotes  -cell differentiation in pancreas development

Development ◽  
2004 ◽  
Vol 131 (24) ◽  
pp. 6163-6174 ◽  
Author(s):  
E. B. Harmon
Keyword(s):  
Cell Differentiation ◽  
Progenitor Cell ◽  
Cell Number ◽  
Pancreas Development

scholarly journals MFng Is Dispensable for Mouse Pancreas Development and Function

2009 ◽  
Vol 29 (8) ◽  
pp. 2129-2138 ◽  
Author(s):  
Per Svensson ◽  
Ingela Bergqvist ◽  
Stefan Norlin ◽  
Helena Edlund
Keyword(s):  
Cell Differentiation ◽  
Notch Signaling ◽  
Pancreas Development ◽  
Loss Of Function ◽  
Pancreatic Cell ◽  
Targeted Deletion ◽  
Mouse Pancreas ◽  
Pancreatic Progenitor ◽  
Pancreatic Progenitor Cells ◽  
And Function

ABSTRACT Notch signaling regulates pancreatic cell differentiation, and mutations of various Notch signaling components result in perturbed pancreas development. Members of the Fringe family of β1,3-N-acetylglucosaminyltransferases, Manic Fringe (MFng), Lunatic Fringe (LFng), and Radical Fringe (RFng), modulate Notch signaling, and MFng has been suggested to regulate pancreatic endocrine cell differentiation. We have characterized the expression of the three mouse Fringe genes in the developing mouse pancreas between embryonic days 9 and 14 and show that the expression of MFng colocalized with the proendocrine transcription factor Ngn3. In contrast, the expression of LFng colocalized with the exocrine marker Ptf1a, whereas RFng was not expressed. Moreover, we show that expression of MFng is lost in Ngn3 mutant mice, providing evidence that MFng is genetically downstream of Ngn3. Gain- and loss-of-function analyses of MFng by the generation of mice that overexpress MFng in early pancreatic progenitor cells and mice with a targeted deletion of MFng provide, however, evidence that MFng is dispensable for pancreas development and function, since no pancreatic defects in these mice were observed.

scholarly journals Endothelial progenitor cell number is not decreased in 34 children with Juvenile Dermatomyositis: a pilot study

2017 ◽  
Vol 15 (1) ◽  
Author(s):  
Dong Xu ◽  
Akadia Kacha-Ochana ◽  
Gabrielle A. Morgan ◽  
Chiang-Ching Huang ◽  
Lauren M. Pachman
Keyword(s):  
Pilot Study ◽  
Endothelial Progenitor Cell ◽  
Progenitor Cell ◽  
Juvenile Dermatomyositis ◽  
Cell Number ◽  
Endothelial Progenitor

scholarly journals Pericytes Stimulate Oligodendrocyte Progenitor Cell Differentiation during CNS Remyelination

Cell Reports ◽  
2017 ◽  
Vol 20 (8) ◽  
pp. 1755-1764 ◽  
Author(s):  
Alerie Guzman De La Fuente ◽  
Simona Lange ◽  
Maria Elena Silva ◽  
Ginez A. Gonzalez ◽  
Herbert Tempfer ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Progenitor Cell ◽  
Oligodendrocyte Progenitor Cell ◽  
Oligodendrocyte Progenitor

scholarly journals Ectopic Expression of Oct-4 Blocks Progenitor-Cell Differentiation and Causes Dysplasia in Epithelial Tissues

Cell ◽  
2005 ◽  
Vol 121 (3) ◽  
pp. 465-477 ◽  
Author(s):  
Konrad Hochedlinger ◽  
Yasuhiro Yamada ◽  
Caroline Beard ◽  
Rudolf Jaenisch
Keyword(s):  
Cell Differentiation ◽  
Progenitor Cell ◽  
Ectopic Expression ◽  
Epithelial Tissues
Sign in / Sign up

Export Citation Format

Share Document