scholarly journals Essential role of Gata transcription factors in sympathetic neuron development

Development ◽  
2004 ◽  
Vol 131 (19) ◽  
pp. 4775-4786 ◽  
Author(s):  
K. Tsarovina
Keyword(s):  
Transcription Factors ◽  
Essential Role ◽  
Sympathetic Neuron ◽  
Neuron Development ◽  
Gata Transcription Factors

scholarly journals The essential role of GATA transcription factors in adult murine prostate

Oncotarget ◽  
2016 ◽  
Vol 7 (30) ◽  
pp. 47891-47903 ◽  
Author(s):  
Lijuan Xiao ◽  
Qin Feng ◽  
Zheng Zhang ◽  
Fen Wang ◽  
John P. Lydon ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Essential Role ◽  
Gata Transcription Factors

scholarly journals SRC-3, a Steroid Receptor Coactivator: Implication in Cancer

2021 ◽  
Vol 22 (9) ◽  
pp. 4760
Author(s):  
Licen Li ◽  
Chu-Xia Deng ◽  
Qiang Chen
Keyword(s):  
Breast Cancer ◽  
Transcription Factors ◽  
Cancer Therapy ◽  
Nuclear Receptors ◽  
Essential Role ◽  
Transcriptional Activity ◽  
Steroid Receptor ◽  
Steroid Receptor Coactivator ◽  
Important Progress

Steroid receptor coactivator-3 (SRC-3), also known as amplified in breast cancer 1 (AIB1), is a member of the SRC family. SRC-3 regulates not only the transcriptional activity of nuclear receptors but also many other transcription factors. Besides the essential role of SRC-3 in physiological functions, it also acts as an oncogene to promote multiple aspects of cancer. This review updates the important progress of SRC-3 in carcinogenesis and summarizes its mode of action, which provides clues for cancer therapy.

scholarly journals Essential Role of TEA Domain Transcription Factors in the Negative Regulation of the MYH 7 Gene by Thyroid Hormone and Its Receptors

PLoS ONE ◽  
2014 ◽  
Vol 9 (4) ◽  
pp. e88610 ◽  
Author(s):  
Hiroyuki Iwaki ◽  
Shigekazu Sasaki ◽  
Akio Matsushita ◽  
Kenji Ohba ◽  
Hideyuki Matsunaga ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Thyroid Hormone ◽  
Essential Role ◽  
Negative Regulation

Zebrafish Growth Factor Independence Transcription Factors Establish a New Paradigm for Regulation of Primitive and Definitive Hematopoietic Lineages,

Blood ◽  
2011 ◽  
Vol 118 (21) ◽  
pp. 3379-3379
Author(s):  
Jeffrey D. Cooney ◽  
Ebrahim Shafizadeh ◽  
Paul F. McBride ◽  
Kelli J. Carroll ◽  
Heidi Anderson ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Growth Factor ◽  
Essential Role ◽  
Cell Mass ◽  
Intermediate Cell ◽  
New Paradigm ◽  
Hematopoietic Stem ◽  
Isolation And Characterization ◽  
Definitive Hematopoiesis

Abstract Abstract 3379 The Growth Factor Independence (Gfi) zinc finger transcription factors play essential roles in hematopoiesis, differentially activating and repressing transcriptional programs required for hematopoietic lineage specification. In mammals, Gfi1 regulates hematopoietic stem cell (HSC) and lymphoid populations, while Gfi1b is required for megakaryocyte and erythroid development (van der Meer, et al. 2010 Leukemia 11:1834–43). In zebrafish, gfi1.1 plays an essential role in primitive hematopoiesis, preserving primitive HSC populations and regulating the erythroid-myeloid balance (Wei, et al. 2008 Cell Res. 6:677–85). However, little is known about the role of gfi1.1 in definitive hematopoiesis or about the role of additional hematopoietic gfi family members in zebrafish. Here, we report the isolation and characterization of an additional zebrafish gfi family transcription factor, gfi1.2b. We compare and contrast gfi1.1 and gfi1.2b, showing that they are highly expressed in the intermediate cell mass (ICM) and aorta-gonad-mesonephros (AGM), the respective sites of primitive and definitive hematopoiesis in zebrafish. Using antisense morpholino oligos (MO), whole mount in situ hybridization (WISH) and fluorescent activated cell sorting (FACS) of transgenic reporter fish, we demonstrate that gfi1.1 and gfi1.2b have distinct, essential roles in preserving primitive and definitive HSC populations, respectively. Loss of gfi1.1 specifically silences expression of scl and gata-1, markers of primitive HSC and erythroid progenitors. Conversely, loss of gfi1.2b silences expression of Tg(cd41:eGFPlo) cells, indicating an essential role for gfi1.2b in preserving definitive hematopoietic progenitors (Ma, et al. 2011 Blood 118:289–297). Consistent with the discrete roles of gfi1.1 and gfi1.2b in primitive and definitive lineages, knockdown of gfi1.2b silences lymphocyte rag-1 expression in the developing thymus, while knockdown of gfi1.1 has no effect on the thymic lymphocyte population. gfi1.1 and gfi1.2b have overlapping roles in erythropoiesis, as loss of either gfi factor reduces erythrocyte populations, while loss of both gfi paralogs results in a more profound silencing of erythrocytes. We further demonstrate that loss of gata-1 reduces gfi1.1 expression and silences gfi1.2b, suggesting that gata-1 plays an essential role in regulating the transcription of both genes. Together, these studies demonstrate that gfi1.1 and gfi1.2b have distinct and overlapping roles in zebrafish hematopoiesis and establish a new paradigm for the regulation of primitive and definitive hematopoietic lineages by gfi transcription factors. Disclosures: No relevant conflicts of interest to declare.

Essential role of Jun family transcription factors in PU.1 knockdown–induced leukemic stem cells

2006 ◽  
Vol 38 (11) ◽  
pp. 1269-1277 ◽  
Author(s):  
Ulrich Steidl ◽  
Frank Rosenbauer ◽  
Roel G W Verhaak ◽  
Xuesong Gu ◽  
Alexander Ebralidze ◽  
...  
Keyword(s):  
Stem Cells ◽  
Transcription Factors ◽  
Essential Role ◽  
Leukemic Stem Cells

scholarly journals The AP-1 transcription factors c-Jun and JunB are essential for CD8α conventional dendritic cell identity

2021 ◽  
Author(s):  
Philipp Novoszel ◽  
Barbara Drobits ◽  
Martin Holcmann ◽  
Cristiano De Sa Fernandes ◽  
Roland Tschismarov ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Listeria Monocytogenes ◽  
Dendritic Cell ◽  
Essential Role ◽  
Activator Protein 1 ◽  
Fate Specification ◽  
Cross Presentation ◽  
Listeria Monocytogenes Infection ◽  
And Function

AbstractDendritic cell (DC) development is orchestrated by lineage-determining transcription factors (TFs). Although, members of the activator-protein-1 (AP-1) family, including Batf3, have been implicated in conventional (c)DC specification, the role of Jun proteins is poorly understood. Here, we identified c-Jun and JunB as essential for cDC1 fate specification and function. In mice, Jun proteins regulate extrinsic and intrinsic pathways, which control CD8α cDC1 diversification, whereas CD103 cDC1 development is unaffected. The loss of c-Jun and JunB in DC progenitors diminishes the CD8α cDC1 pool and thus confers resistance to Listeria monocytogenes infection. Their absence in CD8α cDC1 results in impaired TLR triggering and antigen cross-presentation. Both TFs are required for the maintenance of the CD8α cDC1 subset and suppression of cDC2 identity on a transcriptional and phenotypic level. Taken together, these results demonstrate the essential role of c-Jun and JunB in CD8α cDC1 diversification, function, and maintenance of their identity.

scholarly journals BMP growth factors and Phox2 transcription factors can induce synaptotagmin I and neurexin I during sympathetic neuron development

2001 ◽  
Vol 108 (1-2) ◽  
pp. 149-159 ◽  
Author(s):  
Holger Patzke ◽  
Eva Reissmann ◽  
Matthias Stanke ◽  
John L. Bixby ◽  
Uwe Ernsberger
Keyword(s):  
Transcription Factors ◽  
Growth Factors ◽  
Sympathetic Neuron ◽  
Neuron Development ◽  
Synaptotagmin I

scholarly journals The emerging role of GATA transcription factors in development and disease

2016 ◽  
Vol 18 ◽  
Author(s):  
Marjolein HFM Lentjes ◽  
Hanneke EC Niessen ◽  
Yoshimitsu Akiyama ◽  
Adriaan P de Bruïne ◽  
Veerle Melotte ◽  
...  
Keyword(s):  
Stem Cells ◽  
Central Nervous System ◽  
Nervous System ◽  
Transcription Factors ◽  
Embryonic Stem ◽  
Gata Transcription Factors ◽  
Development And Differentiation ◽  
Induction Of Differentiation ◽  
Gata Family

The GATA family of transcription factors consists of six proteins (GATA1-6) which are involved in a variety of physiological and pathological processes. GATA1/2/3 are required for differentiation of mesoderm and ectoderm-derived tissues, including the haematopoietic and central nervous system. GATA4/5/6 are implicated in development and differentiation of endoderm- and mesoderm-derived tissues such as induction of differentiation of embryonic stem cells, cardiovascular embryogenesis and guidance of epithelial cell differentiation in the adult.

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