scholarly journals Hrb27C, Sqd and Otu cooperatively regulate gurken RNA localization and mediate nurse cell chromosome dispersion in Drosophila oogenesis

Development ◽  
2004 ◽  
Vol 131 (9) ◽  
pp. 1949-1958 ◽  
Author(s):  
J. S. Goodrich
Keyword(s):  
Nurse Cell ◽  
Rna Localization ◽  
Drosophila Oogenesis ◽  
Cell Chromosome

The TGF-beta signaling pathway is essential for Drosophila oogenesis

Development ◽  
1996 ◽  
Vol 122 (5) ◽  
pp. 1555-1565 ◽  
Author(s):  
V. Twombly ◽  
R.K. Blackman ◽  
H. Jin ◽  
J.M. Graff ◽  
R.W. Padgett ◽  
...  
Keyword(s):  
Family Member ◽  
Signaling Pathway ◽  
Expression Pattern ◽  
Nurse Cell ◽  
Follicle Cells ◽  
Tgf Beta ◽  
Drosophila Oogenesis ◽  
Egg Chamber

We examine roles of signaling by secreted ligands of the TGF-beta family during Drosophila oogenesis. One family member, the DPP ligand encoded by the decapentaplegic (dpp) gene, is required for patterning of anterior eggshell structures. This requirement presumably reflects the expression pattern of dpp in an anterior subset of somatic follicle cells: the centripetally migrating and the nurse cell-associated follicle cells. Similar requirements are also revealed by mutations in the saxophone (sax)-encoded receptor, consistent with the idea that DPP signaling is, at least in part, mediated by the SAX receptor. A loss of germline sax function results in a block in oogenesis associated with egg chamber degeneration and a failure of the transfer of nurse cell contents to the oocyte, indicating that TGF-beta signaling is required for these events. Some phenotypes of sax mutations during oogenesis suggest that SAX responds to at least one other TGF-beta ligand as well in the posterior follicle cells.

scholarly journals Role of Bicaudal-D in patterning the Drosophila egg chamber in mid-oogenesis

Development ◽  
1996 ◽  
Vol 122 (11) ◽  
pp. 3577-3586 ◽  
Author(s):  
A. Swan ◽  
B. Suter
Keyword(s):  
Cell Migration ◽  
Nurse Cell ◽  
Germ Line ◽  
Follicle Cells ◽  
Oocyte Size ◽  
Hsp70 Promoter ◽  
Oocyte Growth ◽  
Drosophila Oogenesis ◽  
Specific Mrnas

The Bicaudal-D (Bic-D) gene is required early in Drosophila oogenesis for the differentiation of an oocyte from one of a cluster of 16 interconnected germarial cells. To analyze the role of Bic-D later in oogenesis, we have constructed Drosophila lines in which Bic-D expression is under the control of the hsp70 promoter. In these flies, Bic-D activity can be induced early in oogenesis, allowing an oocyte to be made. Then, by shifting females to non-inducing conditions, Bic-D levels are depleted for the remainder of oogenesis. Using this system, we find that Bic-D is indeed required in the later stages of oogenesis. In ovaries from mutant females, oocyte growth is reduced, apparently due to defects in nurse-cell-to-oocyte transport. Smaller oocyte size results in the misalignment of follicle cells and the underlying germ line, leading to ventralization of dorsal follicle cells and to defects in centripetal cell migration. In addition, we show that Bic-D is required for the localization of specific mRNAs at both the anterior and posterior of the oocyte.

scholarly journals Microtubules mediate the localization of bicoid RNA during Drosophila oogenesis

Development ◽  
1991 ◽  
Vol 113 (1) ◽  
pp. 55-66 ◽  
Author(s):  
N.J. Pokrywka ◽  
E.C. Stephenson
Keyword(s):  
Drug Treatment ◽  
Messenger Rna ◽  
Rna Localization ◽  
Proper Function ◽  
Gene Products ◽  
Anterior Cortex ◽  
Drosophila Oogenesis ◽  
Cortical Cytoskeleton

We have examined cytoskeletal requirements for bicoid (bcd) RNA localization during Drosophila oogenesis. bcd is an anterior morphogen whose proper function relies on the localization of its messenger RNA to the anterior cortex of the egg. Drugs that depolymerize microtubules perturb all aspects of bcd RNA localization. During recovery from drug treatment, bcd RNA relocalizes to the oocyte cortex, suggesting that the localization machinery is a component of the cortical cytoskeleton. Taxol, a drug that stabilizes microtubules, also effectively disrupts bcd RNA localization, and the effects of taxol treatments on exuperantia and swallow mutants suggest general roles for these gene products in the multi-step bcd RNA localization process.

scholarly journals γ-Tubulin37C and γ-tubulin ring complex protein 75 Are Essential for bicoid RNA Localization during Drosophila Oogenesis

2002 ◽  
Vol 3 (5) ◽  
pp. 685-696 ◽  
Author(s):  
Frank Schnorrer ◽  
Stefan Luschnig ◽  
Iris Koch ◽  
Christiane Nüsslein-Volhard
Keyword(s):  
Rna Localization ◽  
Drosophila Oogenesis ◽  
Complex Protein ◽  
Ring Complex

scholarly journals polyis required for nurse cell chromosome dispersal and oocyte polarity in Drosophila

Fly ◽  
2010 ◽  
Vol 4 (2) ◽  
pp. 128-136 ◽  
Author(s):  
Stephen Klusza ◽  
Wu-Min Deng
Keyword(s):  
Nurse Cell ◽  
Cell Chromosome
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