scholarly journals Sox9 and Sox10 influence survival and migration of oligodendrocyte precursors in the spinal cord by regulating PDGF receptor   expression

Development ◽  
2008 ◽  
Vol 135 (4) ◽  
pp. 637-646 ◽  
Author(s):  
M. Finzsch ◽  
C. C. Stolt ◽  
P. Lommes ◽  
M. Wegner
Keyword(s):  
Spinal Cord ◽  
Receptor Expression ◽  
Pdgf Receptor ◽  
Oligodendrocyte Precursors ◽  
And Migration

Enhancement in gastric mucosal EGF and PDGF receptor expression with ulcer healing by sulglycotide

1995 ◽  
Vol 26 (4) ◽  
pp. 749-753 ◽  
Author(s):  
J. Piotrowski ◽  
J. Majka ◽  
S. Sano ◽  
P. Nowak ◽  
V.L.N. Murty ◽  
...  
Keyword(s):  
Ulcer Healing ◽  
Receptor Expression ◽  
Pdgf Receptor

Cannabinoid CB1 Receptor Expression in Rat Spinal Cord

2000 ◽  
Vol 15 (6) ◽  
pp. 510-521 ◽  
Author(s):  
W.Paul Farquhar-Smith ◽  
Michaela Egertová ◽  
Elizabeth J. Bradbury ◽  
Stephen B. McMahon ◽  
Andrew S.C. Rice ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Cb1 Receptor ◽  
Receptor Expression ◽  
Cannabinoid Cb1 Receptor ◽  
Rat Spinal Cord

First experience with chronic epidural spinal cord stimulation in Khanty-Mansi autonomous okrug — clinical observations

2021 ◽  
Vol LIII (2) ◽  
pp. 94-100
Author(s):  
Olga A. Bondarenko ◽  
Gaspar V. Gavrilov ◽  
Vadim A. Padurets ◽  
Roman V. Kasich
Keyword(s):  
Spinal Cord ◽  
Neuropathic Pain ◽  
Spinal Cord Stimulation ◽  
Pain Syndrome ◽  
Chronic Neuropathic Pain ◽  
Neuropathic Pain Syndrome ◽  
Epidural Stimulation ◽  
Cord Injury ◽  
Epidural Spinal Cord Stimulation ◽  
And Migration

Purpose of the work. The article is devoted to the first experience of epidural stimulation in the Khanty-Mansiysk Autonomous Okrug at the budgetary institution Surgut Clinical Trauma Hospital. Clinical examples are presented for two main indications for the application of this technique (disease of the operated spine, a consequence of spinal cord injury in combination with chronic neuropathic pain syndrome). Research methods. An assessment of the intensity of pain syndrome was given according to a visual analogue scale, the Pain Detect questionnaire; indicators of anxiety, depression on the HADS scale; quality of life according to the Oswestry questionnaire for a follow-up period of 6-12 months in patients with chronic epidural stimulation. Results. A positive assessment of the action during test neurostimulation was 63.3% (38 patients). Of the established permanent systems, a good result was achieved and persisted for 12 months or more in 96% (24 patients). It was necessary to change the stimulation parameters in 13% (3 patients). Revision of permanent systems was performed in 20% (5 patients), due to the progression of the degenerative-dystrophic process of the spine, damage and migration of system elements. Conclusions. Chronic epidural spinal cord stimulation has established itself as a personalized, highly effective, minimally invasive and safe method of treating chronic neuropathic pain syndromes. Multicomponent corrective action is of scientific interest and requires further study.

Spinal cord injury induces early and persistent lesional P2X4 receptor expression

2005 ◽  
Vol 163 (1-2) ◽  
pp. 185-189 ◽  
Author(s):  
Jan M. Schwab ◽  
Lianghao Guo ◽  
Hermann J. Schluesener
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Receptor Expression ◽  
P2x4 Receptor ◽  
Cord Injury

scholarly journals The effect of spinal cord injury on the neurochemical properties of vagal sensory neurons

2015 ◽  
Vol 308 (12) ◽  
pp. R1021-R1033 ◽  
Author(s):  
April N. Herrity ◽  
Jeffrey C. Petruska ◽  
David P. Stirling ◽  
Kristofer K. Rau ◽  
Charles H. Hubscher
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Vagus Nerve ◽  
Sensory Neurons ◽  
Receptor Expression ◽  
Vagal Afferents ◽  
Cord Injury ◽  
Male Wistar Rats ◽  
Neurochemical Plasticity ◽  
Isolectin B4

The vagus nerve is composed primarily of nonmyelinated sensory neurons whose cell bodies are located in the nodose ganglion (NG). The vagus has widespread projections that supply most visceral organs, including the bladder. Because of its nonspinal route, the vagus nerve itself is not directly damaged from spinal cord injury (SCI). Because most viscera, including bladder, are dually innervated by spinal and vagal sensory neurons, an impact of SCI on the sensory component of vagal circuitry may contribute to post-SCI visceral pathologies. To determine whether SCI, in male Wistar rats, might impact neurochemical characteristics of NG neurons, immunohistochemical assessments were performed for P2X3 receptor expression, isolectin B4 (IB4) binding, and substance P expression, three known injury-responsive markers in sensory neuronal subpopulations. In addition to examining the overall population of NG neurons, those innervating the urinary bladder also were assessed separately. All three of the molecular markers were represented in the NG from noninjured animals, with the majority of the neurons binding IB4. In the chronically injured rats, there was a significant increase in the number of NG neurons expressing P2X3 and a significant decrease in the number binding IB4 compared with noninjured animals, a finding that held true also for the bladder-innervating population. Overall, these results indicate that vagal afferents, including those innervating the bladder, display neurochemical plasticity post-SCI that may have implications for visceral homeostatic mechanisms and nociceptive signaling.

A role for CXCR4 signaling in survival and migration of neural and oligodendrocyte precursors

Glia ◽  
2005 ◽  
Vol 50 (3) ◽  
pp. 258-269 ◽  
Author(s):  
M. Dziembowska ◽  
T.N. Tham ◽  
P. Lau ◽  
S. Vitry ◽  
F. Lazarini ◽  
...  
Keyword(s):  
Cxcr4 Signaling ◽  
Oligodendrocyte Precursors ◽  
And Migration

A singularity of PDGF alpha-receptor expression in the dorsoventral axis of the neural tube may define the origin of the oligodendrocyte lineage

Development ◽  
1993 ◽  
Vol 117 (2) ◽  
pp. 525-533 ◽  
Author(s):  
N.P. Pringle ◽  
W.D. Richardson
Keyword(s):  
Spinal Cord ◽  
Cell Fate ◽  
Neural Tube ◽  
Ventricular Zone ◽  
Central Canal ◽  
Receptor Expression ◽  
Foramen Of Monro ◽  
Dorsoventral Axis ◽  
Germinal Zone ◽  
Restricted Region

During rat embryogenesis, PDGF alpha receptor (PDGF-alpha R) mRNA is expressed in the ventral half of the spinal cord in two longitudinal columns, one each side of the central canal. Initially, these columns are only two cells wide but the cells subsequently appear to proliferate and disseminate throughout the spinal cord. Our previous studies of PDGF-alpha R expression in the developing CNS suggested that PDGF-alpha R may be a useful marker of the oligodendrocyte lineage in situ. The data presented here complement those studies and lead us to propose that the earliest oligodendrocyte precursors in the spinal cord originate in a very restricted region of the ventricular zone during a brief window of time around embryonic day 14 (E14). In the embryonic brain, migrating PDGF-alpha R+ cells appear to originate in a localized germinal zone in the ventral diencephalon (beneath the foramen of Monro). Our data demonstrate that gene expression and cell fate can be regulated with exquisite spatial resolution along the dorsoventral axis of the mammalian neural tube.

scholarly journals P2X3 receptor expression in dorsal horn of spinal cord and pain threshold after estrogen therapy for prevention therapy in neuropathic pain

2020 ◽  
Vol 60 ◽  
pp. 389-395
Author(s):  
Rohadi Muhammad Rosyidi ◽  
Bambang Priyanto ◽  
Dewa Putu Wisnu Wardhana ◽  
Krisna Tsaniadi Prihastomo ◽  
Syauq Hikmi ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Neuropathic Pain ◽  
Dorsal Horn ◽  
Pain Threshold ◽  
Estrogen Therapy ◽  
Receptor Expression ◽  
P2x3 Receptor ◽  
Prevention Therapy
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