scholarly journals The role of PAR-1 in regulating the polarised microtubule cytoskeleton in the Drosophila follicular epithelium

Development ◽  
2003 ◽  
Vol 130 (17) ◽  
pp. 3965-3975 ◽  
Author(s):  
H. Doerflinger
Keyword(s):  
Follicular Epithelium ◽  
Microtubule Cytoskeleton

scholarly journals The Role of the Microtubule Cytoskeleton in Regulating Intracellular Transport

2016 ◽  
Vol 110 (3) ◽  
pp. 466a ◽  
Author(s):  
Linda Balabanian ◽  
Christopher L. Berger ◽  
Adam G. Hendricks
Keyword(s):  
Intracellular Transport ◽  
Microtubule Cytoskeleton

scholarly journals The Role of Molecular Microtubule Motors and the Microtubule Cytoskeleton in Stress Granule Dynamics

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Kristen M. Bartoli ◽  
Darryl L. Bishop ◽  
William S. Saunders
Keyword(s):  
Current Literature ◽  
Motor Proteins ◽  
Stress Granules ◽  
Stress Granule ◽  
Microtubule Cytoskeleton ◽  
Microtubule Motors ◽  
Key Players ◽  
Underlying Mechanisms ◽  
Main Components

Stress granules (SGs) are cytoplasmic foci that appear in cells exposed to stress-induced translational inhibition. SGs function as a triage center, where mRNAs are sorted for storage, degradation, and translation reinitiation. The underlying mechanisms of SGs dynamics are still being characterized, although many key players have been identified. The main components of SGs are stalled 48S preinitiation complexes. To date, many other proteins have also been found to localize in SGs and are hypothesized to function in SG dynamics. Most recently, the microtubule cytoskeleton and associated motor proteins have been demonstrated to function in SG dynamics. In this paper, we will discuss current literature examining the function of microtubules and the molecular microtubule motors in SG assembly, coalescence, movement, composition, organization, and disassembly.

scholarly journals Cellular crowding guides and debundles the microtubule cytoskeleton

2019 ◽  
Author(s):  
A. Z. Płochocka ◽  
N. A. Bulgakova ◽  
L. Chumakova
Keyword(s):  
Mathematical Modelling ◽  
Biological Systems ◽  
Follicular Epithelium ◽  
Microtubule Cytoskeleton ◽  
Cytoskeleton Organization ◽  
Cell Organization ◽  
The Mean ◽  
Cellular Components ◽  
The Impact

Cytoplasm is densely packed with macromolecules causing cellular crowding, which alters interactions inside cells and differs between biological systems. Here we investigate the impact of crowding on microtubule cytoskeleton organization. Using mathematical modelling, we find that only anisotropic crowding affects the mean microtubule direction, but any crowding reduces the number of microtubules that form bundles. We validate these predictions in vivo using Drosophila follicular epithelium. Since cellular components are transported along microtubules, our results identify cellular crowding as a novel regulator of this transport and cell organization.

scholarly journals Microtubule Cytoskeleton and Spermatogenesis—Lesson From Studies of Toxicant Models

2020 ◽  
Vol 177 (2) ◽  
pp. 305-315 ◽  
Author(s):  
Lingling Wang ◽  
Ming Yan ◽  
Siwen Wu ◽  
Baiping Mao ◽  
Chris K C Wong ◽  
...  
Keyword(s):  
Molecular Structure ◽  
Bisphenol A ◽  
Sertoli Cells ◽  
Environmental Toxicants ◽  
Microtubule Cytoskeleton ◽  
The Past ◽  
Cellular Events ◽  
Per Se ◽  
To Come

Abstract Studies have shown that mammalian testes, in particular the Sertoli cells, are highly susceptible to exposure of environmental toxicants, such as cadmium, perfluorooctanesulfonate, phthalates, 2,5-hexanedione and bisphenol A. However, important studies conducted by reproductive toxicologists and/or biologists in the past have been treated as toxicology reports per se. Yet, many of these studies provided important mechanistic insights on the toxicant-induced testis injury and reproductive dysfunction, relevant to the biology of the testis and spermatogenesis. Furthermore, recent studies have shown that findings obtained from toxicant models are exceedingly helpful tools to unravel the biology of testis function in particular spermatogenesis, including specific cellular events associated with spermatid transport to support spermiogenesis and spermiation. In this review, we critically evaluate some recent data, focusing primarily on the molecular structure and role of microtubules in cellular function, illustrating the importance of toxicant models to unravel the biology of microtubule cytoskeleton in supporting spermatogenesis, well beyond information on toxicology. These findings have opened up some potential areas of research which should be carefully evaluated in the years to come.

The role of microtubules in transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells.

2005 ◽  
Vol 72 ◽  
pp. 1-13 ◽  
Author(s):  
Krysten J. Palmer ◽  
Peter Watson ◽  
David J. Stephens
Keyword(s):  
Endoplasmic Reticulum ◽  
Mammalian Cells ◽  
Secretory Pathway ◽  
Motor Proteins ◽  
Microtubule Cytoskeleton ◽  
Early Secretory Pathway ◽  
Golgi Transport ◽  
Intracellular Compartments ◽  
Retrograde Traffic

The organization of intracellular compartments and the transfer of components between them are central to the correct functioning of mammalian cells. Proteins and lipids are transferred between compartments by the formation, movement and subsequent specific fusion of transport intermediates. These vesicles and membrane clusters must be coupled to the cytoskeleton and to motor proteins that drive motility. Anterograde ER (endoplasmic reticulum)-to-Golgi transport, and the converse step of retrograde traffic from the Golgi to the ER, are now known to involve coupling of membranes to the microtubule cytoskeleton. Here we shall discuss our current understanding of the mechanisms that link membrane traffic in the early secretory pathway to the microtubule cytoskeleton in mammalian cells. Recent data have also provided molecular detail of functional co-ordination of motor proteins to specify directionality, as well as mechanisms for regulating motor activity by protein phosphorylation.

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