scholarly journals Translational control of meiotic cell cycle progression and spermatid differentiation in male germ cells by a novel eIF4G homolog

Development ◽  
2007 ◽  
Vol 134 (15) ◽  
pp. 2863-2869 ◽  
Author(s):  
C. C. Baker ◽  
M. T. Fuller
Keyword(s):  
Cell Cycle ◽  
Germ Cells ◽  
Translational Control ◽  
Cell Cycle Progression ◽  
Meiotic Cell ◽  
Cycle Progression ◽  
Male Germ Cells

Three genes of the MAP kinase cascade, mek-2, mpk-1/sur-1 and let-60 ras, are required for meiotic cell cycle progression in Caenorhabditis elegans

Development ◽  
1995 ◽  
Vol 121 (8) ◽  
pp. 2525-2535 ◽  
Author(s):  
D.L. Church ◽  
K.L. Guan ◽  
E.J. Lambie
Keyword(s):  
Cell Cycle ◽  
Caenorhabditis Elegans ◽  
Map Kinase ◽  
Germ Cells ◽  
Cell Cycle Progression ◽  
Extended Period ◽  
Meiotic Cell ◽  
Cycle Progression ◽  
C Elegans ◽  
Genetic Mosaic

In the germline of Caenorhabditis elegans hermaphrodites, meiotic cell cycle progression occurs in spatially restricted regions. Immediately after leaving the distal mitotic region, germ cells enter meiosis and thereafter remain in the pachytene stage of first meiotic prophase for an extended period. At the dorsoventral gonadal flexure, germ cells exit pachytene and subsequently become arrested in diakinesis. We have found that exit from pachytene is dependent on the function of three members of the MAP kinase signaling cascade. One of these genes, mek-2, is a newly identified C. elegans MEK (MAP kinase kinase). The other two genes, mpk-1/sur-1 (MAP kinase) and let-60 ras, were previously identified based on their roles in vulval induction and are shown here to act in combination with mek-2 to permit exit from pachytene. Through genetic mosaic analysis, we demonstrate that the expression of mpk-1/sur-1 is required within the germline to permit exit from pachytene.

scholarly journals The Meiosis-Specific Crs1 Cyclin Is Required for Efficient S-Phase Progression and Stable Nuclear Architecture

2021 ◽  
Vol 22 (11) ◽  
pp. 5483
Author(s):  
Luisa F. Bustamante-Jaramillo ◽  
Celia Ramos ◽  
Cristina Martín-Castellanos
Keyword(s):  
Cell Cycle ◽  
Translational Control ◽  
Cell Cycle Progression ◽  
Nuclear Architecture ◽  
Strand Break ◽  
Spindle Pole ◽  
S Phase ◽  
Cycle Progression ◽  
Single Wave ◽  
Phase Progression

Cyclins and CDKs (Cyclin Dependent Kinases) are key players in the biology of eukaryotic cells, representing hubs for the orchestration of physiological conditions with cell cycle progression. Furthermore, as in the case of meiosis, cyclins and CDKs have acquired novel functions unrelated to this primal role in driving the division cycle. Meiosis is a specialized developmental program that ensures proper propagation of the genetic information to the next generation by the production of gametes with accurate chromosome content, and meiosis-specific cyclins are widespread in evolution. We have explored the diversification of CDK functions studying the meiosis-specific Crs1 cyclin in fission yeast. In addition to the reported role in DSB (Double Strand Break) formation, this cyclin is required for meiotic S-phase progression, a canonical role, and to maintain the architecture of the meiotic chromosomes. Crs1 localizes at the SPB (Spindle Pole Body) and is required to stabilize the cluster of telomeres at this location (bouquet configuration), as well as for normal SPB motion. In addition, Crs1 exhibits CDK(Cdc2)-dependent kinase activity in a biphasic manner during meiosis, in contrast to a single wave of protein expression, suggesting a post-translational control of its activity. Thus, Crs1 displays multiple functions, acting both in cell cycle progression and in several key meiosis-specific events.

Involvement of caveolin-1 in meiotic cell-cycle progression in Caenorhabditis elegans

10.1038/10100 ◽  
1999 ◽  
Vol 1 (2) ◽  
pp. 127-129 ◽  
Author(s):  
Jochen Scheel ◽  
Jagan Srinivasan ◽  
Ulrike Honnert ◽  
Annemarie Henske ◽  
Teymuras V. Kurzchalia
Keyword(s):  
Cell Cycle ◽  
Caenorhabditis Elegans ◽  
Cell Cycle Progression ◽  
Meiotic Cell ◽  
Cycle Progression ◽  
Caveolin 1

scholarly journals CNOT 6L couples the selective degradation of maternal transcripts to meiotic cell cycle progression in mouse oocyte

2018 ◽  
Vol 37 (24) ◽  
Author(s):  
Qian‐Qian Sha ◽  
Jia‐Li Yu ◽  
Jing‐Xin Guo ◽  
Xing‐Xing Dai ◽  
Jun‐Chao Jiang ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Progression ◽  
Mouse Oocyte ◽  
Meiotic Cell ◽  
Cycle Progression ◽  
Selective Degradation ◽  
Maternal Transcripts

scholarly journals The A-type cyclins and the meiotic cell cycle in mammalian male germ cells

2004 ◽  
Vol 27 (4) ◽  
pp. 192-199 ◽  
Author(s):  
Debra J. Wolgemuth ◽  
Karen M. Lele ◽  
Vaidehi Jobanputra ◽  
Glicella Salazar
Keyword(s):  
Cell Cycle ◽  
Germ Cells ◽  
Meiotic Cell ◽  
Male Germ Cells

Mitotic cell-cycle progression is regulated by CPEB1 and CPEB4-dependent translational control

2010 ◽  
Vol 12 (5) ◽  
pp. 447-456 ◽  
Author(s):  
Isabel Novoa ◽  
Javier Gallego ◽  
Pedro G. Ferreira ◽  
Raul Mendez
Keyword(s):  
Cell Cycle ◽  
Translational Control ◽  
Cell Cycle Progression ◽  
Mitotic Cell ◽  
Mitotic Cell Cycle ◽  
Cycle Progression

scholarly journals The chromatin remodeler Snf2h is essential for oocyte meiotic cell cycle progression

2020 ◽  
Vol 34 (3-4) ◽  
pp. 166-178
Author(s):  
Chunxia Zhang ◽  
Zhiyuan Chen ◽  
Qiangzong Yin ◽  
Xudong Fu ◽  
Yisi Li ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Progression ◽  
Meiotic Cell ◽  
Chromatin Remodeler ◽  
Cycle Progression

scholarly journals Ceramide Triggers Meiotic Cell Cycle Progression inXenopusOocytes.

1995 ◽  
Vol 270 (22) ◽  
pp. 13541-13547 ◽  
Author(s):  
Jay C. Strum ◽  
Katherine I. Swenson ◽  
J. Eric Turner ◽  
Robert M. Bell
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Progression ◽  
Meiotic Cell ◽  
Cycle Progression
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