scholarly journals Quantitative single cell analysis of cell population dynamics during submandibular salivary gland development and differentiation

Biology Open ◽  
2013 ◽  
Vol 2 (5) ◽  
pp. 439-447 ◽  
Author(s):  
D. A. Nelson ◽  
C. Manhardt ◽  
V. Kamath ◽  
Y. Sui ◽  
A. Santamaria-Pang ◽  
...  
Keyword(s):  
Population Dynamics ◽  
Salivary Gland ◽  
Single Cell ◽  
Cell Population ◽  
Single Cell Analysis ◽  
Submandibular Salivary Gland ◽  
Cell Analysis ◽  
Cell Population Dynamics ◽  
Development And Differentiation ◽  
Gland Development

Mapping single-cell-resolution cell phylogeny reveals cell population dynamics during organ development

2021 ◽  
Vol 18 (12) ◽  
pp. 1506-1514
Author(s):  
Kehui Liu ◽  
Shanjun Deng ◽  
Chang Ye ◽  
Zeqi Yao ◽  
Jianguo Wang ◽  
...  
Keyword(s):  
Population Dynamics ◽  
Single Cell ◽  
Cell Population ◽  
Organ Development ◽  
Cell Population Dynamics ◽  
Resolution Cell

scholarly journals Fractional proliferation: a method to deconvolve cell population dynamics from single-cell data

2012 ◽  
Vol 9 (9) ◽  
pp. 923-928 ◽  
Author(s):  
Darren R Tyson ◽  
Shawn P Garbett ◽  
Peter L Frick ◽  
Vito Quaranta
Keyword(s):  
Population Dynamics ◽  
Single Cell ◽  
Cell Population ◽  
Cell Population Dynamics ◽  
Cell Data

scholarly journals Single-cell analysis reveals a nestin+ tendon stem/progenitor cell population with strong tenogenic potentiality

2016 ◽  
Vol 2 (11) ◽  
pp. e1600874 ◽  
Author(s):  
Zi Yin ◽  
Jia-jie Hu ◽  
Long Yang ◽  
Ze-Feng Zheng ◽  
Cheng-rui An ◽  
...  
Keyword(s):  
Gene Expression ◽  
Single Cell ◽  
Cell Population ◽  
Single Cell Analysis ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Cell Analysis ◽  
Nestin Expression

The repair of injured tendons remains a formidable clinical challenge because of our limited understanding of tendon stem cells and the regulation of tenogenesis. With single-cell analysis to characterize the gene expression profiles of individual cells isolated from tendon tissue, a subpopulation of nestin+ tendon stem/progenitor cells (TSPCs) was identified within the tendon cell population. Using Gene Expression Omnibus datasets and immunofluorescence assays, we found that nestin expression was activated at specific stages of tendon development. Moreover, isolated nestin+ TSPCs exhibited superior tenogenic capacity compared to nestin− TSPCs. Knockdown of nestin expression in TSPCs suppressed their clonogenic capacity and reduced their tenogenic potential significantly both in vitro and in vivo. Hence, these findings provide new insights into the identification of subpopulations of TSPCs and illustrate the crucial roles of nestin in TSPC fate decisions and phenotype maintenance, which may assist in future therapeutic strategies to treat tendon disease.

Author response for "Immunocyte single cell analysis of vaccine‐induced narcolepsy"

2020 ◽  
Author(s):  
Alexander Lind ◽  
Falastin Salami ◽  
Anne‐Marie Landtblom ◽  
Lars Palm ◽  
Åke Lernmark ◽  
...  
Keyword(s):  
Single Cell ◽  
Single Cell Analysis ◽  
Author Response ◽  
Cell Analysis
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