scholarly journals Reelin-dependent ApoER2 downregulation uncouples newborn neurons from progenitor cells

Biology Open ◽  
2012 ◽  
Vol 1 (12) ◽  
pp. 1258-1263 ◽  
Author(s):  
F. J. Perez-Martinez ◽  
A. Luque-Rio ◽  
A. Sakakibara ◽  
M. Hattori ◽  
T. Miyata ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Newborn Neurons

scholarly journals Early emergence of cortical interneuron diversity in the mouse embryo

Science ◽  
2018 ◽  
Vol 360 (6384) ◽  
pp. 81-85 ◽  
Author(s):  
Da Mi ◽  
Zhen Li ◽  
Lynette Lim ◽  
Mingfeng Li ◽  
Monika Moissidis ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Progenitor Cells ◽  
Mouse Embryo ◽  
Neural Circuit ◽  
Aminobutyric Acid ◽  
Gabaergic Interneurons ◽  
Cortical Interneuron ◽  
Cortical Interneurons ◽  
Newborn Neurons ◽  
Functionally Diverse

GABAergic interneurons (GABA, γ-aminobutyric acid) regulate neural-circuit activity in the mammalian cerebral cortex. These cortical interneurons are structurally and functionally diverse. Here, we use single-cell transcriptomics to study the origins of this diversity in the mouse. We identify distinct types of progenitor cells and newborn neurons in the ganglionic eminences, the embryonic proliferative regions that give rise to cortical interneurons. These embryonic precursors show temporally and spatially restricted transcriptional patterns that lead to different classes of interneurons in the adult cerebral cortex. Our findings suggest that shortly after the interneurons become postmitotic, their diversity is already patent in their diverse transcriptional programs, which subsequently guide further differentiation in the developing cortex.

scholarly journals Identification of neural progenitor cells and their progeny reveals long distance migration in the developing octopus brain

2021 ◽  
Author(s):  
Astrid Deryckere ◽  
Ruth Styfhals ◽  
Ali Murat Elagoz ◽  
Gregory E. Maes ◽  
Eve Seuntjens
Keyword(s):  
Progenitor Cells ◽  
Neural Progenitor Cells ◽  
Lineage Tracing ◽  
Octopus Vulgaris ◽  
Long Distance ◽  
Histological Techniques ◽  
Large Brain ◽  
Central Brain ◽  
Dividing Cells ◽  
Newborn Neurons

AbstractCephalopods have evolved nervous systems that parallel the complexity of mammalian brains in terms of neuronal numbers and richness in behavioral output. How the cephalopod brain develops has only been described at the morphological level, and it remains unclear where the progenitor cells are located and what molecular factors drive neurogenesis. Using histological techniques, we located dividing cells, neural progenitors and postmitotic neurons in Octopus vulgaris embryos. Our results indicate that progenitors are located outside the central brain cords in the lateral lips adjacent to the eyes, suggesting that newly formed neurons migrate into the cords. Lineage tracing experiments then showed that progenitors, depending on their location in the lateral lips, generate neurons for the different lobes. The finding that octopus newborn neurons migrate over long distances is reminiscent of vertebrate neurogenesis and suggests it might be a fundamental strategy for large brain development.

scholarly journals Identification of neural progenitor cells and their progeny reveals long distance migration in the developing octopus brain

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Astrid Deryckere ◽  
Ruth Styfhals ◽  
Ali Murat Elagoz ◽  
Gregory E Maes ◽  
Eve Seuntjens
Keyword(s):  
Progenitor Cells ◽  
Neural Progenitor Cells ◽  
Lineage Tracing ◽  
Octopus Vulgaris ◽  
Long Distance ◽  
Histological Techniques ◽  
Large Brain ◽  
Dividing Cells ◽  
Newborn Neurons ◽  
Bhlh Transcription Factors

Cephalopods have evolved nervous systems that parallel the complexity of mammalian brains in terms of neuronal numbers and richness in behavioral output. How the cephalopod brain develops has only been described at the morphological level, and it remains unclear where the progenitor cells are located and what molecular factors drive neurogenesis. Using histological techniques, we located dividing cells, neural progenitors and postmitotic neurons in Octopus vulgaris embryos. Our results indicate that an important pool of progenitors, expressing the conserved bHLH transcription factors achaete-scute or neurogenin, is located outside the central brain cords in the lateral lips adjacent to the eyes, suggesting that newly formed neurons migrate into the cords. Lineage-tracing experiments then showed that progenitors, depending on their location in the lateral lips, generate neurons for the different lobes, similar to the squid Doryteuthis pealeii. The finding that octopus newborn neurons migrate over long distances is reminiscent of vertebrate neurogenesis and suggests it might be a fundamental strategy for large brain development.

scholarly journals A role for Lin28a in aging-associated decline of adult hippocampal neurogenesis

2022 ◽  
Author(s):  
Zhechun Hu ◽  
Jiao Ma ◽  
Huimin Yue ◽  
Xiaofang Li ◽  
Chao Wang ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Neural Progenitor Cells ◽  
Rna Binding ◽  
Functional Integration ◽  
Neural Progenitor ◽  
Hippocampal Neurogenesis ◽  
Adult Hippocampal Neurogenesis ◽  
Pattern Separation ◽  
Neurogenic Niche ◽  
Newborn Neurons

Hippocampal neurogenesis declines with aging. Wnt ligands and antagonists within the hippocampal neurogenic niche regulate the proliferation of neural progenitor cells and the development of new neurons, and the changes of their levels in the niche mediate aging-associated decline of neurogenesis. We found that RNA-binding protein Lin28a remained existent in neural progenitor cells and granule neurons in the adult hippocampus, and decreased with aging. Loss of Lin28a inhibited the responsiveness of neural progenitor cells to niche Wnt agonist and reduced neurogenesis, thus impairing pattern separation. Overexpression of Lin28a increased the proliferation of neural progenitor cells, promoted the functional integration of newborn neurons, restored neurogenesis in Wnt-deficient dentate gyrus, and rescued the impaired pattern separation in aging mice. Our data suggest that Lin28a regulates adult hippocampal neurogenesis as an intracellular mechanism by responding to niche Wnt signals, and its decrease is involved in aging-associated decline of hippocampal neurogenesis as well as related cognitive functions.

Wnt signaling pathway regulates the differentiation of hepatic progenitor cells

2010 ◽  
Vol 34 (8) ◽  
pp. S41-S41
Author(s):  
Yang Bi ◽  
Yun He ◽  
Tingyu Li ◽  
Tao Feng ◽  
Tongchuan He
Keyword(s):  
Wnt Signaling ◽  
Progenitor Cells ◽  
Signaling Pathway ◽  
Wnt Signaling Pathway ◽  
Hepatic Progenitor Cells

Human thymic epithelial cells maintain long-term survival of clonogenic myeloid and erythroid progenitor cells in vitro

2000 ◽  
Vol 111 (1) ◽  
pp. 363-370 ◽  
Author(s):  
Katsuto Takenaka ◽  
Mine Harada ◽  
Tomoaki Fujisaki ◽  
Koji Nagafuji ◽  
Shinichi Mizuno ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Progenitor Cells ◽  
Thymic Epithelial Cells ◽  
Erythroid Progenitor ◽  
Term Survival ◽  
Long Term Survival ◽  
Erythroid Progenitor Cells

“Blastosphere”: A new culture method for human fetal hepatic progenitor cells

2001 ◽  
Vol 120 (5) ◽  
pp. A542-A543
Author(s):  
T HIROSE ◽  
K YASUCHIKA ◽  
T FUJIKAWA ◽  
H FUJII ◽  
S OE ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Culture Method ◽  
Hepatic Progenitor Cells
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