scholarly journals Blocking autophagy enhances the pro-apoptotic effect of bufalin on human gastric cancer cells through endoplasmic reticulum stress

Biology Open ◽  
2017 ◽  
Vol 6 (10) ◽  
pp. 1416-1422 ◽  
Author(s):  
Hongyan Zhao ◽  
Qinghua Li ◽  
Jie Pang ◽  
Huilin Jin ◽  
Hongwei Li ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Cancer Cells ◽  
Human Gastric Cancer ◽  
Gastric Cancer Cells ◽  
Apoptotic Effect

scholarly journals Casticin Potentiates TRAIL-Induced Apoptosis of Gastric Cancer Cells through Endoplasmic Reticulum Stress

PLoS ONE ◽  
2013 ◽  
Vol 8 (3) ◽  
pp. e58855 ◽  
Author(s):  
Yuan Zhou ◽  
Li Tian ◽  
Lingzhi Long ◽  
Meifang Quan ◽  
Fei Liu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Cancer Cells ◽  
Gastric Cancer Cells ◽  
Induced Apoptosis

OSU-03012 induces apoptosis of gastric cancer cells through endoplasmic reticulum stress triggered inhibition of Akt and STAT3 signaling pathways.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e15630-e15630
Author(s):  
Wei Peng ◽  
Xia Xu ◽  
Xiaoxiang Chen ◽  
Jifeng Feng ◽  
Bo Shen ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Cancer Cells ◽  
Dependent Manner ◽  
Preclinical Development ◽  
Gastric Cancer Cells ◽  
Stat3 Signaling ◽  
Caspase Family

e15630 Background: As the chemotherapeutic resistance and postoperative relapse rates of gastric cancer rise year by year, searching for novel chemoprevention compounds has become fairly imminent. 2-amino-N-{4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-phenyl} acetamide (OSU-03012), a derivative of anti-inflammatory drug celecoxib, has recently been shown to have anti-tumor effects. But its roles and underling mechanisms in gastric cancer is rather unknown. Methods: In this study, we show for the first time that OSU-03012 inhibits the growth and potently induces the apoptosis of gastric cancer cells in vitro in a time- and dose-dependent manner. Results: We demonstrate that OSU-03012 induces cell death through endoplasmic reticulum stress (ERS) mediated up-regulation of PTEN, sequentially followed by the suppression of Akt-STAT3 axis, the activation of the mitochondrial membrane protein Bim, mitochondrial damage and finally the release of the caspase family proteases. Conclusions: Our data provide evidences to support OSU-03012 as a potential therapeutic agent for gastric cancer, which may facilitate further preclinical development of anti-tumor drugs.

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