scholarly journals HCN4 ion channel function is required for early events that regulate anatomical left-right patterning in a nodal and lefty asymmetric gene expression-independent manner

Biology Open ◽  
2017 ◽  
Vol 6 (10) ◽  
pp. 1445-1457 ◽  
Author(s):  
Vaibhav P. Pai ◽  
Valerie Willocq ◽  
Emily J. Pitcairn ◽  
Joan M. Lemire ◽  
Jean-François Paré ◽  
...  
Keyword(s):  
Gene Expression ◽  
Ion Channel ◽  
Independent Manner ◽  
Channel Function

scholarly journals Ion Channel Gene Expression in Lung Adenocarcinoma: Potential Role in Prognosis and Diagnosis

PLoS ONE ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. e86569 ◽  
Author(s):  
Jae-Hong Ko ◽  
Wanjun Gu ◽  
Inja Lim ◽  
Hyoweon Bang ◽  
Eun A. Ko ◽  
...  
Keyword(s):  
Gene Expression ◽  
Lung Adenocarcinoma ◽  
Ion Channel ◽  
Potential Role ◽  
Channel Gene ◽  
Ion Channel Gene

scholarly journals From Foe to Friend: Using Animal Toxins to Investigate Ion Channel Function

2015 ◽  
Vol 427 (1) ◽  
pp. 158-175 ◽  
Author(s):  
Jeet Kalia ◽  
Mirela Milescu ◽  
Juan Salvatierra ◽  
Jordan Wagner ◽  
Julie K. Klint ◽  
...  
Keyword(s):  
Ion Channel ◽  
Channel Function

Basic Physiology of Ion Channel Function

2008 ◽  
pp. 11-23
Author(s):  
Isabelle Baró ◽  
Denis Escande†
Keyword(s):  
Ion Channel ◽  
Channel Function

ADP-ribose gates the fertilization channel in ascidian oocytes

1998 ◽  
Vol 275 (5) ◽  
pp. C1277-C1283 ◽  
Author(s):  
Martin Wilding ◽  
Gian Luigi Russo ◽  
Anthony Galione ◽  
Marcella Marino ◽  
Brian Dale
Keyword(s):  
Plasma Membrane ◽  
Ion Channel ◽  
Reversal Potential ◽  
Ciona Intestinalis ◽  
Second Messenger ◽  
Tetraacetic Acid ◽  
Independent Manner ◽  
Unitary Conductance ◽  
Intracellular Ca ◽  
Hydrolysis Of

We report an ion channel in the plasma membrane of unfertilized oocytes of the ascidian Ciona intestinalis that is directly gated by the second messenger ADP-ribose. The ion channel is permeable to Ca2+ and Na+ and is characterized by a reversal potential between 0 and +20 mV and a unitary conductance of 140 pS. Preinjection of the Ca2+ chelator 1,2-bis(2-aminophenoxy)ethane- N, N, N′, N′-tetraacetic acid (BAPTA) or antagonists of intracellular Ca2+ release channels into oocytes did not inhibit the ADP-ribose current, demonstrating that the channel is activated in a Ca2+-independent manner. Both the fertilization current and the current induced by the injection of nicotinamide nucleotides are blocked by nicotinamide, suggesting that the ADP-ribose channel is activated at fertilization in a nicotinamide-sensitive manner. These data suggest that ascidian sperm trigger the hydrolysis of nicotinamide nucleotides in the oocyte to ADP-ribose and that this mechanism is responsible for the production of the fertilization current.

scholarly journals tRNA fragments (tRFs) guide Ago to regulate gene expression post-transcriptionally in a Dicer-independent manner

RNA ◽  
2018 ◽  
Vol 24 (8) ◽  
pp. 1093-1105 ◽  
Author(s):  
Canan Kuscu ◽  
Pankaj Kumar ◽  
Manjari Kiran ◽  
Zhangli Su ◽  
Asrar Malik ◽  
...  
Keyword(s):  
Gene Expression ◽  
Independent Manner ◽  
Regulate Gene Expression ◽  
Regulate Gene
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