scholarly journals BMP-induced reprogramming of the neural retina into retinal pigment epithelium requires Wnt signalling

Biology Open ◽  
2017 ◽  
Vol 6 (7) ◽  
pp. 979-992 ◽  
Author(s):  
Jörg Steinfeld ◽  
Ichie Steinfeld ◽  
Alexander Bausch ◽  
Nicola Coronato ◽  
Meggi-Lee Hampel ◽  
...  
Keyword(s):  
Retinal Pigment Epithelium ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Neural Retina ◽  
Wnt Signalling

Cellular Effects of Detachment and Reattachment on the Neural Retina and the Retinal Pigment Epithelium

Retina ◽  
2013 ◽  
pp. 605-617
Author(s):  
Louisa Wickham ◽  
Geoffrey P. Lewis ◽  
David G. Charteris ◽  
Steven K. Fisher
Keyword(s):  
Retinal Pigment Epithelium ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Neural Retina ◽  
Cellular Effects

Transplantation of intact sheets of fetal neural retina with its retinal pigment epithelium in retinitis pigmentosa patients

2002 ◽  
Vol 133 (4) ◽  
pp. 544-550 ◽  
Author(s):  
Norman D Radtke ◽  
Magdalene J Seiler ◽  
Robert B Aramant ◽  
Heywood M Petry ◽  
Diane J Pidwell
Keyword(s):  
Retinal Pigment Epithelium ◽  
Retinitis Pigmentosa ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Neural Retina

scholarly journals 522. Neural Retina Limits Delivery Non Viral Vectors to Retinal Pigment Epithelium

2006 ◽  
Vol 13 ◽  
pp. S200-S201
Author(s):  
Liesbeth Peeters ◽  
Niek Sanders ◽  
Koen Boussery ◽  
Johan Van de Voorde ◽  
Joseph Demeester ◽  
...  
Keyword(s):  
Retinal Pigment Epithelium ◽  
Viral Vectors ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Neural Retina

Vitamin E in human neural retina and retinal pigment epithelium: Effect of age

1987 ◽  
Vol 6 (8) ◽  
pp. 1051-1055 ◽  
Author(s):  
Daniel T. Organisciak ◽  
Elaine R. Berman ◽  
Hih-Min Wang ◽  
Lynette Feeney-Burns
Keyword(s):  
Vitamin E ◽  
Retinal Pigment Epithelium ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Neural Retina ◽  
Effect Of Age

scholarly journals PALS1 Is Essential for Retinal Pigment Epithelium Structure and Neural Retina Stratification

2011 ◽  
Vol 31 (47) ◽  
pp. 17230-17241 ◽  
Author(s):  
B. Park ◽  
C. H. Alves ◽  
D. M. Lundvig ◽  
N. Tanimoto ◽  
S. C. Beck ◽  
...  
Keyword(s):  
Retinal Pigment Epithelium ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Neural Retina

Diffusible, retinal factors stimulate the barrier properties of junctional complexes in the retinal pigment epithelium

1993 ◽  
Vol 106 (3) ◽  
pp. 859-867 ◽  
Author(s):  
L.J. Rizzolo ◽  
Z.Q. Li
Keyword(s):  
Retinal Pigment Epithelium ◽  
Conditioned Medium ◽  
Tight Junctions ◽  
Electrical Resistance ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Neural Retina ◽  
Transepithelial Electrical Resistance ◽  
Blood Retinal Barrier ◽  
Junctional Complexes

The retinal pigment epithelium lies at the interface between the neural retina and the choriocapillaris where it forms a blood-retinal barrier. Barrier function requires a polarized distribution of plasma membrane proteins and ‘tight’ tight junctions. During chicken embryogenesis, these features develop gradually. Although terminal junctional complexes are established by embryonic day 4, the distribution of the Na+/K(+)-APTase is not polarized in all cells of the epithelium until embryonic day 11. Similarly, the tight junctions of early embryos are leaky, but become tight by hatching (embryonic day 21). We used primary cell culture to examine the molecular basis of this gradual induction of polarized function. Pigment epithelium harvested from embryonic day 7, and cultured on filters, formed monolayers coupled by junctional complexes. The distribution of the Na+/K(+)-ATPase was non-polarized and the tight junctions were leaky with a transepithelial electrical resistance of 20–30 omega cm2. To isolate diffusible factors that stimulate the transepithelial electrical resistance, neural retinas from embryonic day 7, 14 or 16 embryos were incubated at 37 degrees C in base medium for 6 hours. The conditioned medium was added to the apical chamber of freshly cultured pigment epithelium. The distribution of the Na+/K(+)-ATPase became basolateral, and the electrical resistance gradually increased two to three times over 6 days. The increase in electrical resistance corresponded to a decrease in the rate of [3H]inulin diffusion across the monolayer. The effectiveness of the conditioned medium increased steadily with increasing age of the neural retina. Rather than increased production of an active factor, apparently different active factors were produced at different ages.(ABSTRACT TRUNCATED AT 250 WORDS)

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