scholarly journals Zebrafish P54 RNA helicases are cytoplasmic granule residents that are required for development and stress resilience

Biology Open ◽  
2016 ◽  
Vol 5 (10) ◽  
pp. 1473-1484 ◽  
Author(s):  
Cecilia Zampedri ◽  
Maryana Tinoco-Cuellar ◽  
Samantha Carrillo-Rosas ◽  
Abigail Diaz-Tellez ◽  
Jose Luis Ramos-Balderas ◽  
...  
Keyword(s):  
Cytoplasmic Granule ◽  
Rna Helicases ◽  
Stress Resilience

Direct and Moderated Relationships Among Stress, Resilience, Neuroticism, Stigma, and PTSD

2014 ◽  
Author(s):  
Gabriel M. De La Rosa ◽  
Scott L. Johnston ◽  
Jennifer Webb-Murphy ◽  
Stephanie Raducha ◽  
Elizabeth Vishniak
Keyword(s):  
Stress Resilience

Measuring everyday processes and mechanisms of stress resilience: Development and initial validation of the Sustainability of Living Inventory (SOLI).

2019 ◽  
Vol 31 (6) ◽  
pp. 715-729 ◽  
Author(s):  
Wai Kai Hou ◽  
Francisco Tsz Tsun Lai ◽  
Clint Hougen ◽  
Brian J. Hall ◽  
Stevan E. Hobfoll
Keyword(s):  
Stress Resilience ◽  
Initial Validation

Introduction

2019 ◽  
pp. xvi-6
Author(s):  
Kate L. Harkness ◽  
Elizabeth P. Hayden
Keyword(s):  
Mental Health ◽  
Evidence Base ◽  
Integrative Review ◽  
Stress Exposure ◽  
Stress Resilience ◽  
Psychological Models ◽  
Area Of Study

In this introductory chapter, we provide an overview of The Handbook of Stress and Mental Health. We begin by introducing the scope of the issue and critically operationally defining the construct of stress. We then provide a description of the chapters included in the volume, as well as an outline of the purpose of each of the five major sections: Assessment and Definitional Issues, Stress Exposure and Mental Health, Psychological Models, Neurobiological Models, and Stress Resilience and Treatment. The contributors represent international leaders in the field of stress and provide authoritative and integrative review and analysis of the evidence base in this crucial area of study.

Increased MMP-9 levels with strain-dependent stress resilience and tunnel handling in mice

2021 ◽  
pp. 113288
Author(s):  
Kate Kennedy-Wood ◽  
Christi Anne S. Ng ◽  
Seham Alaiyed ◽  
Patricia L. Foley ◽  
Katherine Conant
Keyword(s):  
Stress Resilience ◽  
Strain Dependent

scholarly journals Distinct Ring1b complexes defined by DEAD-box helicases and EMT transcription factors synergistically enhance E-cadherin silencing in breast cancer

2021 ◽  
Vol 12 (2) ◽  
Author(s):  
Yawei Wang ◽  
Yingying Sun ◽  
Chao Shang ◽  
Lili Chen ◽  
Hongyu Chen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Transcription Factors ◽  
Cancer Cells ◽  
Epithelial Mesenchymal Transition ◽  
Epigenetic Mechanism ◽  
Regulation Mechanism ◽  
Rna Helicases ◽  
Mesenchymal Transition ◽  
Dead Box ◽  
E Cadherin

AbstractRing1b is a core subunit of polycomb repressive complex 1 (PRC1) and is essential in several high-risk cancers. However, the epigenetic mechanism of Ring1b underlying breast cancer malignancy is poorly understood. In this study, we showed increased expression of Ring1b promoted metastasis by weakening cell–cell adhesions of breast cancer cells. We confirmed that Ring1b could downregulate E-cadherin and contributed to an epigenetic rewiring via PRC1-dependent function by forming distinct complexes with DEAD-box RNA helicases (DDXs) or epithelial-mesenchymal transition transcription factors (EMT TFs) on site-specific loci of E-cadherin promoter. DDXs-Ring1b complexes moderately inhibited E-cadherin, which resulted in an early hybrid EMT state of epithelial cells, and EMT TFs-Ring1b complexes cooperated with DDXs-Ring1b complexes to further repress E-cadherin in mesenchymal-like cancer cells. Clinically, high expression of Ring1b with DDXs or EMT TFs predicted low levels of E-cadherin, metastatic behavior, and poor prognosis. These findings provide an epigenetic regulation mechanism of Ring1b complexes in E-cadherin expression. Ring1b complexes may be potential therapeutic targets and biomarkers for diagnosis and prognosis in invasion breast cancer.

Regulation of RNA helicase activity: principles and examples

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Pascal Donsbach ◽  
Dagmar Klostermeier
Keyword(s):  
Atp Hydrolysis ◽  
Wide Spectrum ◽  
Mrna Translation ◽  
Rna Degradation ◽  
Rna Helicases ◽  
Interaction Partners ◽  
Rna Duplexes ◽  
Self Association

Abstract RNA helicases are a ubiquitous class of enzymes involved in virtually all processes of RNA metabolism, from transcription, mRNA splicing and export, mRNA translation and RNA transport to RNA degradation. Although ATP-dependent unwinding of RNA duplexes is their hallmark reaction, not all helicases catalyze unwinding in vitro, and some in vivo functions do not depend on duplex unwinding. RNA helicases are divided into different families that share a common helicase core with a set of helicase signature motives. The core provides the active site for ATP hydrolysis, a binding site for the non-sequence-specific interactions with RNA, and in many cases a basal unwinding activity. Its activity is often regulated by flanking domains, by interaction partners, or by self-association. In this review, we summarize the regulatory mechanisms that modulate the activities of the helicase core. Case studies on selected helicases with functions in translation, splicing, and RNA sensing illustrate the various modes and layers of regulation in time and space that harness the helicase core for a wide spectrum of cellular tasks.

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