scholarly journals On the asymptotic robustness of the likelihood ratio test in quantitative trait locus detection

2014 ◽  
Vol 8 (2) ◽  
pp. 2138-2157
Author(s):  
Charles-Elie Rabier
Keyword(s):  
Quantitative Trait Locus ◽  
Likelihood Ratio ◽  
Likelihood Ratio Test ◽  
Quantitative Trait ◽  
Quantitative Trait Locus Detection ◽  
Ratio Test ◽  
Asymptotic Robustness ◽  
Trait Locus

scholarly journals Testing the Robustness of the Likelihood-Ratio Test in a Variance-Component Quantitative-Trait Loci–Mapping Procedure

1999 ◽  
Vol 65 (2) ◽  
pp. 531-544 ◽  
Author(s):  
David B. Allison ◽  
Michael C. Neale ◽  
Raffaella Zannolli ◽  
Nicholas J. Schork ◽  
Christopher I. Amos ◽  
...  
Keyword(s):  
Quantitative Trait Loci ◽  
Likelihood Ratio ◽  
Likelihood Ratio Test ◽  
Quantitative Trait ◽  
Variance Component ◽  
Ratio Test ◽  
Quantitative Trait Loci Mapping ◽  
Mapping Procedure ◽  
Trait Loci

Quantitative trait locus mapping of genes regulating pulmonary PKC activity and PKC-α content

2000 ◽  
Vol 279 (2) ◽  
pp. L326-L332 ◽  
Author(s):  
Lori D. Dwyer-Nield ◽  
Beverly Paigen ◽  
Stephanie E. Porter ◽  
Alvin M. Malkinson
Keyword(s):  
Quantitative Trait Locus ◽  
Likelihood Ratio ◽  
Quantitative Trait ◽  
Single Gene ◽  
Inbred Mouse ◽  
Likelihood Ratio Statistic ◽  
Mouse Strains ◽  
Chromosome 11 ◽  
Major Locus ◽  
Trait Locus

Strain A/J mice, which are predisposed to experimentally induced asthma and adenocarcinoma, have the lowest pulmonary protein kinase (PK) C activity and content among 22 inbred mouse strains. PKC in neonatal A/J mice is similar to that in other strains, so this difference reflects strain-dependent postnatal regulation. PKC activity is 60% higher in C57BL/6J (B6) than in A/J lungs, and the protein and mRNA concentrations of PKC-α, the major pulmonary PKC isozyme, are two- to threefold higher in B6 mice. These differences result from more than a single gene as assessed in F1, F2, and backcross progeny of B6 and A/J parents. Quantitative trait locus (QTL) analysis of 23 A×B and B×A recombinant inbred strains derived from B6 and A/J progenitors indicates a major locus regulating lung PKC-α content that maps near the Pkcα structural gene on chromosome 11 ( D11MIT333; likelihood ratio statistic = 12.5) and a major locus controlling PKC activity that maps on chromosome 3 ( D3MIT19; likelihood ratio statistic = 15.4). The chromosome 11 QTL responsible for low PKC-α content falls within QTLs for susceptibilities to lung tumorigenesis and ozone-induced toxicity.

scholarly journals Quantitative trait locus detection in commercial broiler lines using candidate regions1

2003 ◽  
Vol 81 (5) ◽  
pp. 1158-1165 ◽  
Author(s):  
D. J. de Koning ◽  
D. Windsor ◽  
P. M. Hocking ◽  
D. W. Burt ◽  
A. Law ◽  
...  
Keyword(s):  
Quantitative Trait Locus ◽  
Quantitative Trait ◽  
Quantitative Trait Locus Detection ◽  
Commercial Broiler ◽  
Trait Locus
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