The Impact of Cardiopulmonary Bypass on Systemic Interleukin-6 Release, Cerebral Nuclear Factor-kappa B Expression, and Neurocognitive Outcome in Rats

2010 ◽  
Vol 110 (2) ◽  
pp. 312-320 ◽  
Author(s):  
Bettina Jungwirth ◽  
Barbara Eckel ◽  
Manfred Blobner ◽  
Kristine Kellermann ◽  
Eberhard F. Kochs ◽  
...  
Keyword(s):  
Cardiopulmonary Bypass ◽  
Interleukin 6 ◽  
Nuclear Factor Kappa B ◽  
Nuclear Factor ◽  
Neurocognitive Outcome ◽  
Nuclear Factor Kappa ◽  
The Impact

Nuclear factor kappa B subunit p50 promotes melanoma angiogenesis by upregulating interleukin-6 expression

2009 ◽  
Vol 124 (2) ◽  
pp. 494-501 ◽  
Author(s):  
Alison M. Karst ◽  
Kai Gao ◽  
Colleen C. Nelson ◽  
Gang Li
Keyword(s):  
Interleukin 6 ◽  
Nuclear Factor Kappa B ◽  
Nuclear Factor ◽  
B Subunit ◽  
Nuclear Factor Kappa

Early Activation of Pulmonary Nuclear Factor kappa B and Nuclear Factor Interleukin-6 in Polymicrobial Sepsis

1999 ◽  
Vol 46 (4) ◽  
pp. 590-596 ◽  
Author(s):  
William Browder ◽  
Tuanzhu Ha ◽  
Chuanfu Li ◽  
John H. Kalbfleisch ◽  
Donald A. Ferguson ◽  
...  
Keyword(s):  
Interleukin 6 ◽  
Nuclear Factor Kappa B ◽  
Polymicrobial Sepsis ◽  
Nuclear Factor ◽  
Nuclear Factor Kappa ◽  
Early Activation

The protective role of etoricoxib against diethylnitrosamine/2-acetylaminofluorene-induced hepatocarcinogenesis in Wistar rats: The impact of NF-κB/COX-2/PGE2 signaling

2021 ◽  
Vol 14 ◽  
Author(s):  
Gaber F. Ali ◽  
Hany A. Omar ◽  
Fatema Hersi ◽  
Amira M. Abo-Youssef ◽  
Osama M. Ahmed ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Wistar Rats ◽  
Nuclear Factor Kappa B ◽  
Interleukin 1 ◽  
Lipid Peroxide ◽  
Nuclear Factor ◽  
Nonalcoholic Fatty Liver ◽  
Nuclear Factor Kappa ◽  
Cox 2 ◽  
The Impact

Background: Liver cancer ranks as the 7th and 5th leading cause of cancer morbidity worldwide in men and women, respectively. Hepatocellular carcinoma (HCC) is the most common type of liver cancer and is associated with an increasing global burden of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). Objective: The present study aimed to investigate the possible chemopreventive effect of etoricoxib on diethylnitrosamine (DENA) and 2-acetylaminofluorene (2AAF)-induced HCC in male Wistar rats. Methods: HCC was induced by DENA (150 mg/kg/week; i.p) for 2 weeks, then 2AAF (20 mg/kg; p.o) every other day for three successive weeks. Etoricoxib (0.6 mg/kg, p.o.) was given to DENA/2AAF-administered rats for 20 weeks. Results: Etoricoxib significantly suppressed alpha-fetoprotein (AFP) and carbohydrate antigen 19-9 (CA19.9) as liver tumor biomarkers. It also decreased serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and total bilirubin levels while increasing serum albumin levels. Besides, it alleviated DENA/2AAF-induced histopathological abrasions and inflammatory cell infiltration. Furthermore, etoricoxib showed a potent antioxidant effect, supported by a significant lipid peroxide reduction and elevation in superoxide dismutase and GSH content activity. In addition, Etoricoxib significantly down-regulated the protein expression of interleukin 1 beta (IL-1β), tumor necrosis factor α (TNFα), nuclear Factor-kappa B (NF-κB), phosphorylated nuclear Factor-kappa B (p-NF-κB), cyclooxygenase-2 (COX-2), and prostaglandin E2 (PGE2). Conclusion: In conclusion, the current results proved that etoricoxib possesses an anticarcinogenic effect via its antioxidant, anti-inflammatory, and modulation of NF-κB/COX-2/PGE2 signaling.

A lymphoid cell-specific nuclear factor containing c-Rel-like proteins preferentially interacts with interleukin-6 kappa B-related motifs whose activities are repressed in lymphoid cells

1992 ◽  
Vol 12 (4) ◽  
pp. 1736-1746
Author(s):  
K Nakayama ◽  
H Shimizu ◽  
K Mitomo ◽  
T Watanabe ◽  
S Okamoto ◽  
...  
Keyword(s):  
Interleukin 6 ◽  
Lymphoid Cell ◽  
Nuclear Factor Kappa B ◽  
Lymphoid Cells ◽  
Nuclear Factor ◽  
Nuclear Factor Kappa ◽  
Factor Ii ◽  
Binding Factor

The proto-oncoprotein c-Rel is a member of the nuclear factor kappa B transcription factor family, which includes the p50 and p65 subunits of nuclear factor kappa B. We show here that c-Rel binds to kappa B sites as homodimers as well as heterodimers with p50. These homodimers and heterodimers show distinct DNA-binding specificities and affinities for various kappa B motifs. In particular, the c-Rel homodimer has a high affinity for interleukin-6 (IL-6) and beta interferon kappa B sites. In spite of its association with p50 in vitro, however, we found a lymphoid cell-specific nuclear factor in vivo that contains c-Rel but not p50 epitopes; this factor, termed IL-6 kappa B binding factor II, appears to contain the c-Rel homodimer and preferentially recognizes several IL-6 kappa B-related kappa B motifs. Although it has been previously shown that the IL-6 kappa B motif functions as a potent IL-1/tumor necrosis factor-responsive element in nonlymphoid cells, its activity was found to be repressed in lymphoid cells such as a Jurkat T-cell line. We also present evidence that IL-6 kappa B binding factor II functions as a repressor specific for IL-6 kappa B-related kappa B motifs in lymphoid cells.

Abstract 15197: Lipopolysaccharide-Nuclear Factor-kappa B Pathway and Lipoprotein Apheresis Effects in Patients With Familial Hypercholesterolemia and Coronary Artery Disease

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Huihui Liu ◽  
Cheng-Gang Zhu ◽  
Chuan-Jue Cui ◽  
Yexuan Cao ◽  
Jinglu Jin ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Familial Hypercholesterolemia ◽  
Interleukin 6 ◽  
Nuclear Factor Kappa B ◽  
Mononuclear Cells ◽  
Nuclear Factor ◽  
Lipoprotein Apheresis ◽  
Nuclear Factor Kappa ◽  
Artery Disease

Introduction: Inflammation may play an important role in atherosclerosis in familial hypercholesterolemia (FH). Lipopolysaccharide (LPS)-nuclear factor-kappa B (NF-κB) pathway is a routine signal process activated in inflammatory status. Hypothesis: We assessed the hypothesis that LPS-NF-κB axis is markedly activated and lipoprotein apheresis has an inhibitory effect on this pathway in patients with FH and coronary artery disease (CAD). Methods: In this matched case-control study a genetically diagnosed FH cohort who presented stable CAD (n=63) was compared with 63 non-FH CAD and 63 non-FH non-CAD controls matched by sex and age. Plasma LPS levels and NF-κB activity were compared among the three groups. In addition, we studied in vitro LPS-induced interleukin-6 production by mononuclear cells from 16 FH cases without previous statin use and compared them with their respective matched control groups. Subsequently, these 16 FH patients underwent lipoprotein apheresis. Blood samples were taken immediately before and regularly after apheresis for measuring LPS and NF-κB. Results: FH plus CAD had higher LPS levels and NF-κB activity than CAD and non-CAD controls (all p <0.01). LPS-induced interleukin-6 production by mononuclear cells of FH plus CAD was also much higher compared with CAD and non-CAD controls (both p <0.01). Moreover, plasma LPS levels ( p <0.001) and NF-κB activity ( p <0.01) were dramatically reduced after apheresis in FH patients. Conclusions: In conclusion, genetically confirmed FH patients with CAD had a marked activation of LPS-NF-κB axis, while lipoprotein apheresis significantly attenuated this key inflammatory pathway, suggesting that inflammation may be an important therapeutic target for FH patients.

Nuclear factor-kappa B and interleukin-6 related docetaxel resistance in castration-resistant prostate cancer

The Prostate ◽  
2012 ◽  
Vol 73 (5) ◽  
pp. 512-521 ◽  
Author(s):  
Jordi Codony-Servat ◽  
Mercedes Marín-Aguilera ◽  
Laura Visa ◽  
Xabier García-Albéniz ◽  
Estela Pineda ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Interleukin 6 ◽  
Nuclear Factor Kappa B ◽  
Nuclear Factor ◽  
Castration Resistant Prostate Cancer ◽  
Nuclear Factor Kappa ◽  
Docetaxel Resistance ◽  
Castration Resistant
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