Skin permeation of retinol in Tween 20-based deformable liposomes: in-vitro evaluation in human skin and keratinocyte models

2006 ◽  
Vol 58 (2) ◽  
pp. 161-166 ◽  
Author(s):  
Yu-Kyoung Oh ◽  
Mi Young Kim ◽  
Jee-Young Shin ◽  
Tae Woon Kim ◽  
Mi-Ok Yun ◽  
...  
Keyword(s):  
Human Skin ◽  
Skin Permeation ◽  
Tween 20 ◽  
In Vitro Evaluation

scholarly journals Penetration of Chlorhexidine into Human Skin

2008 ◽  
Vol 52 (10) ◽  
pp. 3633-3636 ◽  
Author(s):  
T. J. Karpanen ◽  
T. Worthington ◽  
B. R. Conway ◽  
A. C. Hilton ◽  
T. S. J. Elliott ◽  
...  
Keyword(s):  
Human Skin ◽  
High Performance ◽  
Skin Permeation ◽  
Full Thickness ◽  
Alternative Strategies ◽  
Thickness Skin ◽  
Skin Antisepsis ◽  
Permeation Studies ◽  
Franz Diffusion Cells

ABSTRACT This study evaluated a model of skin permeation to determine the depth of delivery of chlorhexidine into full-thickness excised human skin following topical application of 2% (wt/vol) aqueous chlorhexidine digluconate. Skin permeation studies were performed on full-thickness human skin using Franz diffusion cells with exposure to chlorhexidine for 2 min, 30 min, and 24 h. The concentration of chlorhexidine extracted from skin sections was determined to a depth of 1,500 μm following serial sectioning of the skin using a microtome and analysis by high-performance liquid chromatography. Poor penetration of chlorhexidine into skin following 2-min and 30-min exposures to chlorhexidine was observed (0.157 ± 0.047 and 0.077 ± 0.015 μg/mg tissue within the top 100 μm), and levels of chlorhexidine were minimal at deeper skin depths (less than 0.002 μg/mg tissue below 300 μm). After 24 h of exposure, there was more chlorhexidine within the upper 100-μm sections (7.88 ± 1.37 μg/mg tissue); however, the levels remained low (less than 1 μg/mg tissue) at depths below 300 μm. There was no detectable penetration through the full-thickness skin. The model presented in this study can be used to assess the permeation of antiseptic agents through various layers of skin in vitro. Aqueous chlorhexidine demonstrated poor permeation into the deeper layers of the skin, which may restrict the efficacy of skin antisepsis with this agent. This study lays the foundation for further research in adopting alternative strategies for enhanced skin antisepsis in clinical practice.

Variation of human skin permeation in vitro: Ionic vs neutral compounds

1993 ◽  
Vol 90 (2) ◽  
pp. 171-176 ◽  
Author(s):  
Puchun Liu ◽  
James A.S. Nightingale ◽  
Tamie Kurihara-Bergstrom
Keyword(s):  
Human Skin ◽  
Skin Permeation ◽  
Neutral Compounds

Influence of skin permeation enhancers on the transdermal delivery of palonosetron: An in vitro evaluation

2018 ◽  
Vol 16 (3) ◽  
pp. 192-197 ◽  
Author(s):  
Anroop B. Nair ◽  
Shery Jacob ◽  
Bandar E. Al-Dhubiab ◽  
Rakan Naser Alhumam
Keyword(s):  
Transdermal Delivery ◽  
Skin Permeation ◽  
Permeation Enhancers ◽  
In Vitro Evaluation

scholarly journals Usefulness of Rat Skin as a Substitute for Human Skin in the in Vitro Skin Permeation Study

2011 ◽  
Vol 60 (4) ◽  
pp. 373-384 ◽  
Author(s):  
Hiroyuki TAKEUCHI ◽  
Yoko MANO ◽  
Shuichi TERASAKA ◽  
Takanobu SAKURAI ◽  
Atsushi FURUYA ◽  
...  
Keyword(s):  
Human Skin ◽  
Skin Permeation ◽  
Rat Skin ◽  
Permeation Study ◽  
In Vitro Skin Permeation

Studies with Emulsion Containing trans-resveratrol: in vitro Release Profile and ex vivo Human Skin Permeation

2015 ◽  
Vol 12 (2) ◽  
pp. 157-165 ◽  
Author(s):  
Priscila de Almeida ◽  
Michele Alves ◽  
Hudson Polonini ◽  
Stephane Calixto ◽  
Tiago Braga Gomes ◽  
...  
Keyword(s):  
Human Skin ◽  
Ex Vivo ◽  
Skin Permeation ◽  
In Vitro Release ◽  
Release Profile ◽  
Vitro Release
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