Inhibitory effect of salmosin, a Korean snake venomderived disintegrin, on the integrin αv-mediated proliferation of SK-Mel-2 human melanoma cells

2003 ◽  
Vol 55 (11) ◽  
pp. 1577-1582 ◽  
Author(s):  
Kwang-Hoe Chung ◽  
Sung-Hoon Kim ◽  
Kyu-yeon Han ◽  
Young-Doug Sohn ◽  
Soo-Ik Chang ◽  
...  
Keyword(s):  
Inhibitory Effect ◽  
Melanoma Cells ◽  
Human Melanoma ◽  
Integrin Αv ◽  
Human Melanoma Cells

Inhibitory effect by polyunsaturated fatty acids on melanogenesis in cultured human melanoma cells

1992 ◽  
Vol 4 (2) ◽  
pp. 115
Author(s):  
R. Hashizume ◽  
H. Doi ◽  
J. Hirano ◽  
S. Fukushima ◽  
N. Kobayashi ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Inhibitory Effect ◽  
Melanoma Cells ◽  
Human Melanoma ◽  
Human Melanoma Cells

scholarly journals Flavonoids Bearing an O-Arabinofuranosyl-(1→3)-Rhamnoside Moiety from Cladocolea Micrantha: Inhibitory Effect on Human Melanoma Cells

2012 ◽  
Vol 7 (10) ◽  
pp. 1934578X1200701
Author(s):  
Anderson C. Guimarães ◽  
Alvicler Magalhães ◽  
Marcos J. Nakamura ◽  
Antonio C. Siani ◽  
Christina Barja-Fidalgo ◽  
...  
Keyword(s):  
Gallic Acid ◽  
Spectral Methods ◽  
Inhibitory Effect ◽  
Melanoma Cells ◽  
Human Melanoma ◽  
Human Melanoma Cells ◽  
Derivatives Of ◽  
Transwell System

Eleven known triterpenes (α-amyrin, β-amyrin, lupeol, and their respective acetates, 3- O-acetyl derivatives of betulinic, oleanolic, and ursolic acids, cycloartenol, and tirucall-7,24-dienol), two new flavonols presenting an uncommon interglycosidic O-(1→3) linkage (kaempferol 3- O-α-L-arabinofuranosyl-(1→3)-α-L-rhamnoside and quercetin 3- O-α-L-arabinofuranosyl-(1→3)-α-L-rhamnoside), β-sitosterol, stigmasterol, quercetin, and gallic acid were isolated from the Amazonian medicinal mistletoe, Cladocolea micrantha Kuijt (Loranthaceae). Their structures were established by spectral methods and eventual chromatographic comparisons. The quercetin derivative was not cytotoxic to MV3 human melanoma cells, but was able, when administered at 1 μg/mL, to promote a twofold inhibition of the migration of the cells through the transwell system when compared with paclitaxel at 5 μM.

scholarly journals The Influence of Extracts from Common Houseleek (Sempervivum tectorum) on the Metabolic Activity of Human Melanoma Cells WM-266-4

Processes ◽  
2021 ◽  
Vol 9 (9) ◽  
pp. 1549
Author(s):  
Maša Knez Marevci ◽  
Sašo Bjelić ◽  
Barbara Dariš ◽  
Željko Knez ◽  
Maja Leitgeb
Keyword(s):  
Cell Line ◽  
Metabolic Activity ◽  
Soxhlet Extraction ◽  
Extraction Methods ◽  
Inhibitory Effect ◽  
Melanoma Cells ◽  
Human Melanoma ◽  
Specific Cell ◽  
Incurable Cancer ◽  
Human Melanoma Cells

Human melanoma cells are known as one of the most aggressive cancer cells, and consequently, melanoma is one of the most incurable cancer diseases. There is intense activity in research and development of potential medicines for malignant diseases, including alternative forms of remedies. Therefore, the purpose of our work was testing extracts from the common houseleek (Sempervivum tectorum) grown in Slovenia to establish its impact on human melanoma cells. Namely, we wanted to verify if the extracts inhibit growth of malignant cells and their metabolic activity. Soxhlet, cold solvent, ultrasound, and supercritical extraction methods were applied to obtain S. tectorum extracts. Polyphenols and proanthocyanins content in acquired extracts was determined as well as their antioxidative potential. For a relevant comparison, Chinese (CHI) dried and Slovenian (SLO) lyophilized S. tectorum was used. Results showed that the highest contents of polyphenols and proanthocyanins were yielded from lyophilized material, which also had the highest antioxidative potential. The focus of our work was on analysis of possible inhibition effects of the extracts on human melanoma cells since no past studies were found regarding the possible effects of S. tectorum on metabolic activity of WM-266-4. We established that in a 24-h incubation period, the extracts inhibited metabolic activity of the cells at their concentrations of 20, 10, 4, 2, 1, 0.2, and 0.02 mg/mL. Extract obtained from SLO S. tectorum (ultrasound extraction with acetone as a solvent), which showed promising results of inhibitory effect on the mentioned cells, was further described since the local plant was the focus of our study. CHI S. tectorum extract (Soxhlet extraction with ehtanol:water mixture = 1:1 as a solvent) showed the highest inhibitory effect on human melanoma cells WM-266-4, although both obtained extracts are suitable for their growth inhibition of this specific cell line. Our results suggest inhibitory ability of S. tectorum extracts on the metabolic activity of WM-266-4 metastatic cell line, suggesting their potential use as an anticancer agent.

scholarly journals MIR-520f Regulated Itch Expression and Promoted Cell Proliferation in Human Melanoma Cells

Dose-Response ◽  
2020 ◽  
Vol 18 (2) ◽  
pp. 155932582091845 ◽  
Author(s):  
Ming-xia Sun ◽  
Qun An ◽  
La-mei Chen ◽  
Ling Guo
Keyword(s):  
Cell Proliferation ◽  
Melanoma Cell ◽  
Circular Rna ◽  
Inhibitory Effect ◽  
Melanoma Cells ◽  
Human Melanoma ◽  
Human Melanoma Cell ◽  
Human Melanoma Cells ◽  
Potential Biomarker ◽  
Growth Assay

Accumulating evidence suggests that abnormal expression and dysfunction of microRNA is involved in development of cancers. However, the function of miR-520f especially in human melanoma remains elusive. In the current study, the underlying function of miR-520f in human melanoma was investigated. Our study demonstrated that the miR-520f level in human melanoma cell lines and clinical tissues was increased. Overexpression of miR-520f promoted cell proliferation by using the 3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide assay, colony formation, anchorage-independent growth assay, and 5-bromo-2-deoxyuridine assays. Furthermore, we revealed that miR-520f could interact with circular RNA Itchy E3 ubiquitin protein ligase (ITCH) 3′-untranslated region and suppress ITCH expression in human melanoma cells. The inhibitory effect of miR-520f-in could be partially restored by knockdown of ITCH in human melanoma cells. In summary, this study provides novel insights into miR-520f act as a crucial role in the regulation of human melanoma cell growth via regulating ITCH, which might be a potential biomarker and therapeutic target of human melanoma.

Adipocytes Contribute to Resistance of Human Melanoma Cells to Chemotherapy and Targeted Therapy

2014 ◽  
Vol 21 (10) ◽  
pp. 1255-1267 ◽  
Author(s):  
M. Chi ◽  
J. Chen ◽  
Y. Ye ◽  
Hsin-Yi Tseng ◽  
F. Lai ◽  
...  
Keyword(s):  
Targeted Therapy ◽  
Melanoma Cells ◽  
Human Melanoma ◽  
Human Melanoma Cells
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