scholarly journals Heterozygous Mutation within a Kinase-Conserved Motif of the Insulin-Like Growth Factor I Receptor Causes Intrauterine and Postnatal Growth Retardation

2010 ◽  
Vol 24 (2) ◽  
pp. 469-470
Author(s):  
Tassilo Kruis ◽  
Jürgen Klammt ◽  
Assimina Galli-Tsinopoulou ◽  
Tillmann Wallborn ◽  
Marina Schlicke ◽  
...  
Keyword(s):  
Growth Factor ◽  
Growth Retardation ◽  
Postnatal Growth ◽  
Heterozygous Mutation ◽  
Insulin Like Growth Factor ◽  
Postnatal Growth Retardation ◽  
Conserved Motif ◽  
Factor I ◽  
Growth Factor I

scholarly journals Heterozygous Mutation within a Kinase-Conserved Motif of the Insulin-Like Growth Factor I Receptor Causes Intrauterine and Postnatal Growth Retardation

Endocrinology ◽  
2010 ◽  
Vol 151 (2) ◽  
pp. 840-841
Author(s):  
Tassilo Kruis ◽  
Jürgen Klammt ◽  
Assimina Galli-Tsinopoulou ◽  
Tillmann Wallborn ◽  
Marina Schlicke ◽  
...  
Keyword(s):  
Growth Factor ◽  
Growth Retardation ◽  
Postnatal Growth ◽  
Heterozygous Mutation ◽  
Insulin Like Growth Factor ◽  
Postnatal Growth Retardation ◽  
Conserved Motif ◽  
Factor I ◽  
Growth Factor I

The early postnatal development of the murine mandibular condyle is regulated by endogenous insulin-like growth factor-I

1993 ◽  
Vol 137 (1) ◽  
pp. 21-NP ◽  
Author(s):  
G. Maor ◽  
Z. Laron ◽  
R. Eshet ◽  
M. Silbermann
Keyword(s):  
Growth Factor ◽  
Mandibular Condyle ◽  
Postnatal Growth ◽  
Postnatal Period ◽  
Insulin Like Growth Factor ◽  
Intense Staining ◽  
Early Postnatal Development ◽  
Factor I ◽  
Igf I ◽  
Growth Factor I

ABSTRACT Skeletal growth during the early postnatal period is thought to be GH-independent, and is probably regulated by intrinsic growth factors. We studied the involvement of locally produced insulin like growth factor-I (IGF-I) in the growth of the neonatal mandibular condyle. Immunofluorescence studies revealed intense staining with antibodies to IGF-I in the mandibular condyle of 2-day-old ICR mice. We have also shown that these mandibular condyles contain specific high-affinity binding sites (Kd = 0·157 nmol/l) for IGF-I (427 fmol/mg). Autoradiographical studies of iodinated IGF-I revealed that the distribution of the receptors for IGF-I was parallel to that of IGF-I production, mainly in the younger zones of the condyle, namely the chondroprogenitor and the chondroblast cell layers. Immunoinhibition of IGF-I resulted in an almost complete inhibition (−91%) of thymidine incorporation into DNA, as well as in marked degenerative changes in the morphological appearance of the condyle. Our studies support the hypothesis that early postnatal growth is dependent on the paracrine activity of endogenous GH-independent IGF-I. Journal of Endocrinology (1993) 137, 21–26

scholarly journals Neuron-specific Mafb knockout causes growth retardation accompanied by an impaired growth hormone/insulin-like growth factor I axis

2019 ◽  
Vol 68 (4) ◽  
pp. 435-442
Author(s):  
Shayida Maimaiti ◽  
Ryusuke Koshida ◽  
Masami Ojima ◽  
Kaushalya Kulathunga ◽  
Hisashi Oishi ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Factor ◽  
Growth Retardation ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Growth Factor I
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