The retinoic acid receptor-beta 2 contains two separate cell-specific transactivation domains, at the N-terminus and in the ligand-binding domain

1993 ◽  
Vol 7 (4) ◽  
pp. 616-627 ◽  
Author(s):  
G. E. Folkers
Keyword(s):  
Retinoic Acid ◽  
Ligand Binding ◽  
Retinoic Acid Receptor ◽  
Binding Domain ◽  
Acid Receptor ◽  
Transactivation Domains ◽  
N Terminus ◽  
Retinoic Acid Receptor Beta ◽  
Beta 2 ◽  
Receptor Beta

scholarly journals E1A functions as a coactivator of retinoic acid-dependent retinoic acid receptor-beta 2 promoter activation.

1993 ◽  
Vol 7 (4) ◽  
pp. 604-615
Author(s):  
F A Kruyt ◽  
G E Folkers ◽  
A J Walhout ◽  
B J van der Leede ◽  
P T van der Saag
Keyword(s):  
Retinoic Acid ◽  
Retinoic Acid Receptor ◽  
Promoter Activation ◽  
Acid Receptor ◽  
Retinoic Acid Receptor Beta ◽  
Beta 2 ◽  
Receptor Beta

scholarly journals Arg269 and Lys220 of retinoic acid receptor-beta are important for the binding of retinoic acid.

1994 ◽  
Vol 269 (30) ◽  
pp. 19516-19522
Author(s):  
N. Tairis ◽  
J.L. Gabriel ◽  
M. Gyda ◽  
K.J. Soprano ◽  
D.R. Soprano
Keyword(s):  
Retinoic Acid ◽  
Retinoic Acid Receptor ◽  
Acid Receptor ◽  
Retinoic Acid Receptor Beta ◽  
Receptor Beta

Development of the spatial pattern of retinoic acid receptor-beta transcripts in embryonic chick facial primordia

Development ◽  
1992 ◽  
Vol 114 (3) ◽  
pp. 805-813
Author(s):  
A. Rowe ◽  
J.M. Richman ◽  
P.M. Brickell
Keyword(s):  
Retinoic Acid ◽  
Neural Crest ◽  
Retinoic Acid Receptor ◽  
In Situ Hybridisation ◽  
Acid Receptor ◽  
Retinoic Acid Receptor Beta ◽  
Low Levels ◽  
Cranial Neural Crest Cells ◽  
Receptor Beta

Retinoic acid causes a range of embryonic defects, including craniofacial abnormalities, in both birds and mammals and is believed to have a number of roles in normal development. We have previously shown that the distribution of retinoic acid receptor-beta (RAR-beta) transcripts is spatially restricted within the neural-crest-derived upper beak primordia of the chick embryo. We have now used in situ hybridisation to trace the distribution of RAR-beta transcripts during the migration of cranial neural crest cells and during formation of these primordia. RAR-beta transcripts were present in a subset of migrating neural-crest-derived cells in the head of the stage 10 embryo. These cells were situated in pathways followed by cells that migrate from the neural crest overlying the posterior prosencephalic/anterior mesencephalic region of the developing brain. Cells containing RAR-beta transcripts accumulated around the developing eyes and in the regions of the ventral head from which the upper beak primordia later develop. We mapped the distribution of RAR-beta transcripts as the facial primordia were forming, with particular reference to the development of the maxillary primordia. We found that these form in a region of the ventral head that includes the boundary between regions of high and low levels of RAR-beta transcripts. The boundary between these two groups of cells persisted as the maxillary primordia developed.(ABSTRACT TRUNCATED AT 250 WORDS)

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