Amino acid substitutions in the DNA-binding domain of the human androgen receptor are a frequent cause of receptor-binding positive androgen resistance

S. Zoppi

doi:10.1210/me.6.3.409

Amino acid substitutions in the DNA-binding domain of the human androgen receptor are a frequent cause of receptor-binding positive androgen resistance

Molecular Endocrinology ◽

10.1210/me.6.3.409 ◽

1992 ◽

Vol 6 (3) ◽

pp. 409-415 ◽

Cited By ~ 29

Author(s):

S. Zoppi

Keyword(s):

Androgen Receptor ◽

Amino Acid ◽

Dna Binding ◽

Receptor Binding ◽

Binding Domain ◽

Amino Acid Substitutions ◽

Dna Binding Domain ◽

Androgen Resistance ◽

Human Androgen Receptor

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Amino acid substitutions in the DNA-binding domain of the human androgen receptor are a frequent cause of receptor-binding positive androgen resistance.

Molecular Endocrinology ◽

10.1210/mend.6.3.1316540 ◽

1992 ◽

Vol 6 (3) ◽

pp. 409-415

Author(s):

S Zoppi ◽

M Marcelli ◽

J P Deslypere ◽

J E Griffin ◽

J D Wilson ◽

...

Keyword(s):

Androgen Receptor ◽

Amino Acid ◽

Dna Binding ◽

Receptor Binding ◽

Binding Domain ◽

Amino Acid Substitutions ◽

Dna Binding Domain ◽

Androgen Resistance ◽

Human Androgen Receptor

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Discovery of Small-Molecule Inhibitors Selectively Targeting the DNA-Binding Domain of the Human Androgen Receptor

Journal of Medicinal Chemistry ◽

10.1021/jm500802j ◽

2014 ◽

Vol 57 (15) ◽

pp. 6458-6467 ◽

Cited By ~ 51

Author(s):

Huifang Li ◽

Fuqiang Ban ◽

Kush Dalal ◽

Eric Leblanc ◽

Kate Frewin ◽

...

Keyword(s):

Androgen Receptor ◽

Dna Binding ◽

Small Molecule ◽

Small Molecule Inhibitors ◽

Binding Domain ◽

Dna Binding Domain ◽

Human Androgen Receptor

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A mutation in the DNA-binding domain of the androgen receptor gene causes complete testicular feminization in a patient with receptor-positive androgen resistance.

Journal of Clinical Investigation ◽

10.1172/jci115076 ◽

1991 ◽

Vol 87 (3) ◽

pp. 1123-1126 ◽

Cited By ~ 47

Author(s):

M Marcelli ◽

S Zoppi ◽

P B Grino ◽

J E Griffin ◽

J D Wilson ◽

...

Keyword(s):

Androgen Receptor ◽

Dna Binding ◽

Receptor Gene ◽

Androgen Receptor Gene ◽

Binding Domain ◽

Dna Binding Domain ◽

Testicular Feminization ◽

Androgen Resistance

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Complete androgen insensitivity due to mutations in the probable -helical segments of the DNA-binding domain in the human androgen receptor

Human Molecular Genetics ◽

10.1093/hmg/3.1.21 ◽

1994 ◽

Vol 3 (1) ◽

pp. 21-27 ◽

Cited By ~ 31

Author(s):

L. K. Beitel ◽

L. Prior ◽

D. M. Vaslliou ◽

B. Gottlleb ◽

M. Kaufman ◽

...

Keyword(s):

Androgen Receptor ◽

Dna Binding ◽

Binding Domain ◽

Dna Binding Domain ◽

Androgen Insensitivity ◽

Human Androgen Receptor

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Amino acid substitutions in the hormone-binding domain of the human androgen receptor alter the stability of the hormone receptor complex.

Journal of Clinical Investigation ◽

10.1172/jci117507 ◽

1994 ◽

Vol 94 (4) ◽

pp. 1642-1650 ◽

Cited By ~ 36

Author(s):

M Marcelli ◽

S Zoppi ◽

C M Wilson ◽

J E Griffin ◽

M J McPhaul

Keyword(s):

Androgen Receptor ◽

Amino Acid ◽

Hormone Receptor ◽

Binding Domain ◽

Amino Acid Substitutions ◽

Receptor Complex ◽

Hormone Binding ◽

The Stability ◽

Hormone Binding Domain ◽

Human Androgen Receptor

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Faculty Opinions recommendation of Discovery of small-molecule inhibitors selectively targeting the DNA-binding domain of the human androgen receptor.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718506308.793501749 ◽

2014 ◽

Author(s):

Martin Stahl

Keyword(s):

Androgen Receptor ◽

Dna Binding ◽

Small Molecule ◽

Small Molecule Inhibitors ◽

Binding Domain ◽

Dna Binding Domain ◽

Human Androgen Receptor

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Molecular modeling and in vitro investigations of the human androgen receptor DNA-binding domain: application for the study of two mutations

Molecular and Cellular Endocrinology ◽

10.1016/0303-7207(95)03709-8 ◽

1996 ◽

Vol 116 (2) ◽

pp. 137-147 ◽

Cited By ~ 20

Author(s):

J Lobaccaro

Keyword(s):

Androgen Receptor ◽

Molecular Modeling ◽

Dna Binding ◽

Binding Domain ◽

Dna Binding Domain ◽

Human Androgen Receptor

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Correction to Discovery of Small-Molecule Inhibitors Selectively Targeting the DNA-Binding Domain of the Human Androgen Receptor

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.7b00005 ◽

2017 ◽

Vol 60 (3) ◽

pp. 1225-1225 ◽

Cited By ~ 3

Author(s):

Huifang Li ◽

Fuqiang Ban ◽

Kush Dalal ◽

Eric Leblanc ◽

Kate Frewin ◽

...

Keyword(s):

Androgen Receptor ◽

Dna Binding ◽

Small Molecule ◽

Small Molecule Inhibitors ◽

Binding Domain ◽

Dna Binding Domain ◽

Human Androgen Receptor

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A point mutation in the second zinc finger of the DNA-binding domain of the androgen receptor gene causes complete androgen insensitivity in two siblings with receptor-positive androgen resistance

Molecular Endocrinology ◽

10.1210/me.7.7.861 ◽

1993 ◽

Vol 7 (7) ◽

pp. 861-869 ◽

Cited By ~ 15

Author(s):

I. Mowszowicz

Keyword(s):

Androgen Receptor ◽

Dna Binding ◽

Point Mutation ◽

Zinc Finger ◽

Receptor Gene ◽

Androgen Receptor Gene ◽

Binding Domain ◽

Dna Binding Domain ◽

Androgen Insensitivity ◽

Androgen Resistance

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Disentangling the perturbational effects of amino acid substitutions in the DNA-binding domain of p53

Human Genetics ◽

10.1007/s004390050904 ◽

1999 ◽

Vol 104 (1) ◽

pp. 15-22 ◽

Cited By ~ 9

Author(s):

A. I. Wacey ◽

D. N. Cooper ◽

D. Liney ◽

E. Hovig ◽

M. Krawczak

Keyword(s):

Amino Acid ◽

Dna Binding ◽

Binding Domain ◽

Amino Acid Substitutions ◽

Dna Binding Domain

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