Molecular Mechanism of the Vitamin D Antagonistic Actions of (23S)-25-Dehydro-1α-Hydroxyvitamin D3-26,23-Lactone Depends on the Primary Structure of the Carboxyl-Terminal Region of the Vitamin D Receptor

Eiji Ochiai; Daishiro Miura; Hiroshi Eguchi; Sachiko Ohara; Kazuya Takenouchi; Yoshiaki Azuma; Takashi Kamimura; Anthony W. Norman; Seiichi Ishizuka

doi:10.1210/me.2004-0234

Molecular Mechanism of the Vitamin D Antagonistic Actions of (23S)-25-Dehydro-1α-Hydroxyvitamin D3-26,23-Lactone Depends on the Primary Structure of the Carboxyl-Terminal Region of the Vitamin D Receptor

Molecular Endocrinology ◽

10.1210/me.2004-0234 ◽

2005 ◽

Vol 19 (5) ◽

pp. 1147-1157 ◽

Cited By ~ 27

Author(s):

Eiji Ochiai ◽

Daishiro Miura ◽

Hiroshi Eguchi ◽

Sachiko Ohara ◽

Kazuya Takenouchi ◽

...

Keyword(s):

Vitamin D ◽

Molecular Mechanism ◽

Vitamin D Receptor ◽

Primary Structure ◽

Terminal Region ◽

Carboxyl Terminal

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Structural Insights into the Molecular Mechanism of Vitamin D Receptor Activation by Lithocholic Acid Involving a New Mode of Ligand Recognition

Journal of Medicinal Chemistry ◽

10.1021/jm5002524 ◽

2014 ◽

Vol 57 (11) ◽

pp. 4710-4719 ◽

Cited By ~ 34

Author(s):

Anna Y. Belorusova ◽

Jérôme Eberhardt ◽

Noëlle Potier ◽

Roland H. Stote ◽

Annick Dejaegere ◽

...

Keyword(s):

Vitamin D ◽

Molecular Mechanism ◽

Vitamin D Receptor ◽

Lithocholic Acid ◽

Receptor Activation ◽

Ligand Recognition ◽

Structural Insights

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Carboxyl-Terminal Region of Human and Bovine Erythrocyte Carbonic Anhydrases. 2. Primary Structure Studies around a Methionine Residue

European Journal of Biochemistry ◽

10.1111/j.1432-1033.1968.tb00436.x ◽

1968 ◽

Vol 6 (2) ◽

pp. 190-195 ◽

Cited By ~ 11

Author(s):

B. Andersson ◽

P. O. Gothe ◽

T. Nilsson ◽

P. O. Nyman ◽

L. Strid

Keyword(s):

Primary Structure ◽

Terminal Region ◽

Carbonic Anhydrases ◽

Bovine Erythrocyte ◽

Methionine Residue ◽

Carboxyl Terminal

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The C-terminal region of the vitamin D receptor is essential to form a complex with a receptor auxiliary factor required for high affinity binding to the vitamin D-responsive element

Molecular Endocrinology ◽

10.1210/me.8.2.159 ◽

1994 ◽

Vol 8 (2) ◽

pp. 159-172 ◽

Cited By ~ 31

Author(s):

S. Nakajima

Keyword(s):

Vitamin D ◽

Vitamin D Receptor ◽

Terminal Region ◽

Affinity Binding ◽

High Affinity Binding ◽

High Affinity ◽

Responsive Element ◽

Auxiliary Factor

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Analysis of the Molecular Mechanism for the Antagonistic Action of a Novel 1α,25-Dihydroxyvitamin D3Analogue toward Vitamin D Receptor Function

Journal of Biological Chemistry ◽

10.1074/jbc.274.45.32376 ◽

1999 ◽

Vol 274 (45) ◽

pp. 32376-32381 ◽

Cited By ~ 51

Author(s):

Keiichi Ozono ◽

Mariko Saito ◽

Daishiro Miura ◽

Toshimi Michigami ◽

Shigeo Nakajima ◽

...

Keyword(s):

Vitamin D ◽

Molecular Mechanism ◽

Vitamin D Receptor ◽

Receptor Function ◽

Antagonistic Action

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Analysis of Molecular Mechanism of Cancer Cell Differentiation and Apoptosis Induced by Vitamin D3 Analogs on the Basis of Molecular Recognition of Vitamin D Receptor Ligand Binding Domain

YAKUGAKU ZASSHI ◽

10.1248/yakushi.122.781 ◽

2002 ◽

Vol 122 (10) ◽

pp. 781-791 ◽

Cited By ~ 4

Author(s):

Kimie NAKAGAWA

Keyword(s):

Vitamin D ◽

Cell Differentiation ◽

Molecular Recognition ◽

Ligand Binding ◽

Molecular Mechanism ◽

Cancer Cell ◽

Vitamin D Receptor ◽

Binding Domain ◽

Ligand Binding Domain ◽

Receptor Ligand

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The C-terminal region of the vitamin D receptor is essential to form a complex with a receptor auxiliary factor required for high affinity binding to the vitamin D-responsive element.

Molecular Endocrinology ◽

10.1210/mend.8.2.8170472 ◽

1994 ◽

Vol 8 (2) ◽

pp. 159-172

Author(s):

S Nakajima ◽

J C Hsieh ◽

P N MacDonald ◽

M A Galligan ◽

C A Haussler ◽

...

Keyword(s):

Vitamin D ◽

Vitamin D Receptor ◽

Terminal Region ◽

Affinity Binding ◽

High Affinity Binding ◽

High Affinity ◽

Responsive Element ◽

Auxiliary Factor

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Characterization of Unique DNA-Binding and Transcriptional-Activation Functions in the Carboxyl-Terminal Extension of the Zinc Finger Region in the Human Vitamin D Receptor†

Biochemistry ◽

10.1021/bi9916574 ◽

1999 ◽

Vol 38 (49) ◽

pp. 16347-16358 ◽

Cited By ~ 28

Author(s):

Jui-Cheng Hsieh ◽

G. Kerr Whitfield ◽

Anish K. Oza ◽

Hope T. L. Dang ◽

Jack N. Price ◽

...

Keyword(s):

Vitamin D ◽

Dna Binding ◽

Zinc Finger ◽

Vitamin D Receptor ◽

Transcriptional Activation ◽

Activation Functions ◽

Carboxyl Terminal ◽

Zinc Finger Region

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Analysis of Molecular Mechanism of Cancer Cell Differentiation and Apoptosis Induced by Vitamin D3 Analogues on the Basis of Molecular Recognition of Vitamin D Receptor Ligand Binding Domain

ChemInform ◽

10.1002/chin.200305279 ◽

2003 ◽

Vol 34 (5) ◽

Author(s):

Kimie Nakagawa

Keyword(s):

Vitamin D ◽

Cell Differentiation ◽

Molecular Recognition ◽

Ligand Binding ◽

Molecular Mechanism ◽

Cancer Cell ◽

Vitamin D Receptor ◽

Vitamin D3 ◽

Binding Domain ◽

Receptor Ligand

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Molecular mechanism of vitamin D receptor action

Inflammation Research ◽

10.1007/s000110050360 ◽

1998 ◽

Vol 47 (12) ◽

pp. 451-475 ◽

Cited By ~ 77

Author(s):

L. L. Issa ◽

G. M. Leong ◽

J. A. Eisman

Keyword(s):

Vitamin D ◽

Molecular Mechanism ◽

Vitamin D Receptor ◽

Receptor Action

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Vitamin D Receptor Phosphorylation in Transfected ROS 17/2.8 Cells Is Localized to the N-Terminal Region of the Hormone-Binding Domain

Molecular Endocrinology ◽

10.1210/mend-5-8-1137 ◽

1991 ◽

Vol 5 (8) ◽

pp. 1137-1146 ◽

Cited By ~ 25

Author(s):

Barbara B. Jones ◽

Peter W. Jurutka ◽

Carol A. Haussler ◽

Mark R. Haussler ◽

G. Kerr Whitfield

Keyword(s):

Vitamin D ◽

Vitamin D Receptor ◽

Binding Domain ◽

Terminal Region ◽

Hormone Binding ◽

Receptor Phosphorylation ◽

Hormone Binding Domain

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