scholarly journals Multiple Messenger Ribonucleic Acid Variants Regulate Cell-Specific Expression of Human Thyroid Hormone Receptor β1

2004 ◽  
Vol 18 (7) ◽  
pp. 1631-1642 ◽  
Author(s):  
Sarah Frankton ◽  
Clare B. Harvey ◽  
Lisa M. Gleason ◽  
Abdessamad Fadel ◽  
Graham R. Williams
Keyword(s):  
Thyroid Hormone ◽  
Ribonucleic Acid ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Human Thyroid ◽  
Specific Expression ◽  
Messenger Ribonucleic Acid

Thyroid hormone receptor messenger ribonucleic acid in human granulosa and ovarian stromal cells

1994 ◽  
Vol 62 (3) ◽  
pp. 531-534 ◽  
Author(s):  
Anthony N. Wakim ◽  
William R. Paljug ◽  
Katherine M. Jasnosz ◽  
Nawar Alhakim ◽  
Anne B. Brown ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Stromal Cells ◽  
Ribonucleic Acid ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Messenger Ribonucleic Acid

Prolonged Fasting Reduces Rat Hepaticβ1 Thyroid Hormone Receptor Protein without Changing the Level of Its Messenger Ribonucleic Acid*

Endocrinology ◽  
1991 ◽  
Vol 129 (6) ◽  
pp. 2881-2885 ◽  
Author(s):  
JAMES T. LANE ◽  
MADAN GODBOLE ◽  
KEVIN A. STRAIT ◽  
HAROLD L. SCHWARTZ ◽  
JACK H. OPPENHEIMER
Keyword(s):  
Thyroid Hormone ◽  
Ribonucleic Acid ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Receptor Protein ◽  
Prolonged Fasting ◽  
Messenger Ribonucleic Acid

scholarly journals Transient Expression of c-erbAβ1 Messenger Ribonucleic Acid andβ 1 Thyroid Hormone Receptor Early in Adipogenesis of Ob 17 Cells*

Endocrinology ◽  
1999 ◽  
Vol 140 (7) ◽  
pp. 2983-2990 ◽  
Author(s):  
Alexandra Dace ◽  
Gaiane Sarkissian ◽  
Laetitia Schneider ◽  
Claire Martin-El Yazidi ◽  
Jeannine Bonne ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Transient Expression ◽  
Ribonucleic Acid ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Messenger Ribonucleic Acid

scholarly journals Thyroid hormone receptor β mutations in the ‘hot-spot region’ are rare events in thyroid carcinomas

2007 ◽  
Vol 192 (1) ◽  
pp. 83-86 ◽  
Author(s):  
Ana Sofia Rocha ◽  
Ricardo Marques ◽  
Inês Bento ◽  
Ricardo Soares ◽  
João Magalhães ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Thyroid Hormone ◽  
Transgenic Mice ◽  
Cell Lines ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Hot Spot ◽  
Direct Sequencing ◽  
Human Thyroid ◽  
Thyroid Hormone Receptor Β

Thyroid cancer constitutes the most frequent endocrine neoplasia. Targeted expression of rearranged during transfection (RET)/papillary thyroid carcinoma (PTC) and V600E V-raf murine sarcoma viral oncogene homolog B1 (BRAF) to the thyroid glands of transgenic mice results in tumours similar to those of human PTC, providing evidence for the involvement of these oncogenes in PTC. Kato et al. developed a mouse model that mimics the full spectrum of the human follicular form of thyroid cancer (FTC). FTC rapidly develops in these mice through introduction of the thyroid hormone receptor β (THRB)PV mutant on the background of the inactivated THRB wt locus. Our aim was to verify if, in the context of human follicular thyroid carcinogenesis, THRB acted as a tumour suppressor gene. We screened for mutations of the THRB gene in the hot-spot region, spanning exons 7–10, in 51 thyroid tumours and six thyroid cancer cell lines by PCR and direct sequencing. We did not find mutations in any of the tumours or cell lines analysed. Our findings suggest that, in contrast to the findings on the THRB-mutant transgenic mice, THRB gene mutations are not a relevant mechanism for human thyroid carcinogenesis.

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