Nerve Growth Factor Regulates Dopamine D2 Receptor Expression in Prolactinoma Cell Lines via p75NGFR-Mediated Activation of Nuclear Factor- B

2002 ◽  
Vol 16 (2) ◽  
pp. 353-366 ◽  
Author(s):  
C. Fiorentini
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Cell Lines ◽  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Receptor Expression ◽  
Nuclear Factor ◽  
Factor B ◽  
Nerve Growth ◽  
Dopamine D2

scholarly journals Nerve Growth Factor Regulates Dopamine D2 Receptor Expression in Prolactinoma Cell Lines via p75NGFR-Mediated Activation of Nuclear Factor-κB

2002 ◽  
Vol 16 (2) ◽  
pp. 353-366 ◽  
Author(s):  
Chiara Fiorentini ◽  
Nicoletta Guerra ◽  
Marco Facchetti ◽  
Alessandra Finardi ◽  
Laura Tiberio ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Cell Lines ◽  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Nuclear Factor Κb ◽  
Receptor Expression ◽  
Nuclear Factor ◽  
Nerve Growth ◽  
Dopamine D2

scholarly journals Immunohistochemical analysis of nerve growth factor receptor expression in normal and malignant human tissues.

1988 ◽  
Vol 36 (4) ◽  
pp. 383-389 ◽  
Author(s):  
P G Chesa ◽  
W J Rettig ◽  
T M Thomson ◽  
L J Old ◽  
M R Melamed
Keyword(s):  
Nervous System ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Normal Development ◽  
Malignant Tumors ◽  
Sympathetic Neurons ◽  
Growth Factor Receptor ◽  
Nerve Growth Factor Receptor ◽  
Receptor Expression ◽  
Nerve Growth

Nerve growth factor (NGF) is a polypeptide important for normal development of the nervous system and promotion of survival and differentiation of sensory and sympathetic neurons in culture. The cellular effects of NGF are mediated by a specific cell surface molecule, nerve growth factor receptor (NGF-R). In the present study we have used a monoclonal antibody against human NGF-R to examine, by the avidin-biotin-immunoperoxidase method, the receptor distribution in a wide range of normal tissues and in more than 200 malignant tumors. Our results show that (a) human NGF-R is expressed in the peripheral nervous system but not in any of the central nervous system areas tested; (b) NGF-R expression is not restricted to neural tissues but is also found in a number of normal epithelial, mesenchymal, and lymphoid tissues; (c) NGF-R expression changes during normal development; and (d) NGF-R expression in malignant tumors generally parallels its normal tissue distribution. Thus, NGF-R is detected in a proportion of neuroectoderm-derived tumors, carcinomas, and lymphomas, and also in a characteristic group of small round-cell tumors (Ewing's sarcomas and embryonal rhabdomyosarcomas). These findings suggest a normal regulatory role for NGF in both neuronal and non-neuronal cells and identify a range of human tumors in which the NGF/NGF-R system may contribute to the malignant phenotype.

Dopamine D2 receptor expression in the corticotroph cells of the human normal pituitary gland

Endocrine ◽  
2016 ◽  
Vol 57 (2) ◽  
pp. 314-325 ◽  
Author(s):  
Rosario Pivonello ◽  
Marlijn Waaijers ◽  
Johan M. Kros ◽  
Claudia Pivonello ◽  
Cristina de Angelis ◽  
...  
Keyword(s):  
Pituitary Gland ◽  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Receptor Expression ◽  
Dopamine D2 ◽  
Normal Pituitary Gland
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