scholarly journals Effects of Opioid Antagonism on Cerebrospinal Fluid Melanocortin Peptides and Cortisol Levels in Humans

2017 ◽  
Vol 1 (10) ◽  
pp. 1235-1246 ◽  
Author(s):  
Rebecca J Gordon ◽  
Sunil K Panigrahi ◽  
Kana Meece ◽  
Deniz Atalayer ◽  
Richard Smiley ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Melanocortin Peptides ◽  
Cortisol Levels

scholarly journals Increased Cortisol Levels in Aging and Alzheimer's Disease in Postmortem Cerebrospinal Fluid

1994 ◽  
Vol 6 (6) ◽  
pp. 681-687 ◽  
Author(s):  
D. F. Swaab ◽  
F. C. Raadsheer ◽  
E. Endert ◽  
M. A. Hofman ◽  
W. Kamphorst ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrospinal Fluid ◽  
Cortisol Levels

scholarly journals Cortisol levels in cerebrospinal fluid correlate with severity and bacterial origin of meningitis

Critical Care ◽  
2007 ◽  
Vol 11 (2) ◽  
pp. R41 ◽  
Author(s):  
Michal Holub ◽  
Ondřej Beran ◽  
Olga Džupová ◽  
Jarmila Hnyková ◽  
Zdenka Lacinová ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Bacterial Origin ◽  
Cortisol Levels

Cortisol is increased in postmortem cerebrospinal fluid of multiple sclerosis patients: relationship with cytokines and sepsis

2002 ◽  
Vol 8 (3) ◽  
pp. 229-236 ◽  
Author(s):  
Z A Erkut ◽  
E Endert ◽  
I Huitinga ◽  
D F Swaab
Keyword(s):  
Multiple Sclerosis ◽  
Cerebrospinal Fluid ◽  
Hpa Axis ◽  
Complex Interactions ◽  
Tnf Α ◽  
Cytokine Levels ◽  
Stimulation Tests ◽  
Cortisol Levels ◽  
Highly Correlated ◽  
Multiple Sclerosis Patients

Hypothalamo-pituitary-adrenal (HPA) axis activity is altered in patients with multiple sclerosis (MS), resulting in elevated basal levels and enhanced response of cortisol in stimulation tests. HPA axis hyperactivation in MS is thought to be the result of complex interactions of genetic, immunologic, and neuroendocrinological mechanisms. In order to investigate whether cytokine levels in the central nervous system are associated with the activation of the HPA axis in MS, we measured cortisol, interleukin (IL)-6, IL-10 and TNF-α levels in postmortem cerebrospinal fluid (CSF) of 18 patients with severe MS and 50 controls. We also investigated the cortisol and cytokine levels in the CSF of a group of MS patients and controls who died with sepsis, in order to see whether acute infectious situations affect the association between cortisol and cytokines. The cortisol levels in MS patients were increased by 80% in comparison to controls (p =0.008). There was no difference in IL-6 levels between the groups, while IL-10 and TNF-α levels of the majority of subjects were below detection limits. There was a positive correlation between cortisol and IL-6 only in control patients with sepsis (r=0.89, p =0.019), but not within the MS patients with sepsis or MS and control groups without sepsis. Cortisol levels in postmortem serum and CSF were highly correlated (r >0.78, p <0.001). We concluded that the basal level of cortisol is significantly increased in the CSF of MS patients and that IL-6 is not responsible for this rise. The relationship between cortisol and IL-6 in sepsis is discussed.

Cerebrospinal fluid and plasma free cortisol concentrations in depression

1976 ◽  
Vol 6 (2) ◽  
pp. 235-244 ◽  
Author(s):  
Bernard J. Carroll ◽  
George C. Curtis ◽  
J. Mendels
Keyword(s):  
Cerebrospinal Fluid ◽  
Bipolar Depression ◽  
Equilibrium Dialysis ◽  
Unipolar Depression ◽  
The United States ◽  
Urinary Free Cortisol ◽  
Free Cortisol ◽  
Cortisol Levels ◽  
Cns Exposure ◽  
Good Agreement

SynopsisCerebrospinal fluid (CSF) cortisol levels were examined in a total group of 65 patients. Those who were not depressed (ND), and those suffering from depressive neuroses (DN) had marginally elevated values. Patients with unipolar depression (UD) and bipolar depression (BD) had levels twice as high as the ND and DN patients. Psychotic UD and BD patients had the highest values, three to four times as high as the ND and DN subjects. A significant reduction of CSF cortisol levels was observed following treatment and recovery. Manic patients had moderately elevated CSF cortisol values. The CSF results were in good agreement with plasma total cortisol levels and with urinary free cortisol excretion. Age and sex effects were not responsible for the observed differences; similar results were found in patient subgroups studied in Australia and in the United States. Preliminary equilibrium dialysis data are presented for plasma and CSF cortisol binding. CSF cortisol was 20% bound and 80% free. Plasma free cortisol levels were in good agreement with CSF free cortisol values. Depressed patients have increased tissue and central nervous system (CNS) exposure to free, physiologically active glucocorticoids. The appearance of severe depressive symptoms which manifest a diurnal rhythm may be determined in part by excessive CNS exposure to glucocorticoids.

scholarly journals Preoperative Cerebrospinal Fluid Cortisol and the Risk of Postoperative Delirium: A Prospective Study of Older Hip Fracture Patients

2020 ◽  
Vol 49 (6) ◽  
pp. 604-610
Author(s):  
Joost Witlox ◽  
Dimitrios Adamis ◽  
Leo Koenderman ◽  
Kees Kalisvaart ◽  
Jos F.M. de Jonghe ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cerebrospinal Fluid ◽  
Hip Fracture ◽  
Postoperative Delirium ◽  
Rating Scale ◽  
The Elderly ◽  
Confusion Assessment Method ◽  
Assessment Method ◽  
Cortisol Levels ◽  
A Prospective Study

<b><i>Background:</i></b> Ageing, depression, and neurodegenerative disease are common risk factors for delirium in the elderly. These risk factors are associated with dysregulation of the hypothalamic-pituitary-adrenal axis, resulting in higher levels of cortisol under normal and stressed conditions and a slower return to baseline. <b><i>Objectives:</i></b> We investigated whether elevated preoperative cerebrospinal fluid (CSF) cortisol levels are associated with the onset of postoperative delirium. <b><i>Methods:</i></b> In a prospective cohort study CSF samples were collected after cannulation for the introduction of spinal anesthesia of 75 patients aged 75 years and older admitted for surgical repair of acute hip fracture. Delirium was assessed with the confusion assessment method (CAM) and the Delirium Rating Scale-Revised-98 (DRS-R98). Because the CAM and DRS-R98 were available for time of admission and 5 postoperative days, we used generalized estimating equations and linear mixed modeling to examine the association between preoperative CSF cortisol levels and the onset of postoperative delirium. <b><i>Results:</i></b> Mean age was 83.5 (SD 5.06) years, and prefracture cognitive decline was present in one-third of the patients (24 [33%]). Postoperative delirium developed in 27 (36%) patients. We found no association between preoperative CSF cortisol levels and onset or severity of postoperative delirium. <b><i>Conclusions:</i></b> These findings do not support the hypothesis that higher preoperative CSF cortisol levels are associated with the onset of postoperative delirium in elderly hip fracture patients.

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