scholarly journals Patients with Cushing’s Disease Secrete Adrenocorticotropin and Cortisol Jointly More Asynchronously than Healthy Subjects

1998 ◽  
Vol 83 (2) ◽  
pp. 688-692 ◽  
Author(s):  
Ferdinand Roelfsema ◽  
Steven M. Pincus ◽  
Johannes D. Veldhuis
Keyword(s):  
Cushing’S Disease ◽  
Healthy Subjects ◽  
Cushing's Disease

Somatomedin A levels in patients with Cushing's disease

1981 ◽  
Vol 97 (1) ◽  
pp. 12-17 ◽  
Author(s):  
Marja Thorén ◽  
Kerstin Hall ◽  
Tiit Rähn
Keyword(s):  
Direct Effect ◽  
Cushing’S Disease ◽  
Healthy Subjects ◽  
Serum Levels ◽  
Significant Rise ◽  
Radioreceptor Assay ◽  
Cushing's Disease ◽  
Stereotactic Radiation ◽  
Retarding Effect ◽  
Selective Impairment

Abstract. The serum levels of immunoreactive somatomedin A (SMA) in 23 patients with Cushing's disease, aged 6–61 years, were within the range of healthy subjects for their ages. No correlation was found between SMA and the excretion of cortisol. After im administration of hGH (8 IU = 4 mg) daily for 3 days there was a significant rise in SMA, both determined by radioimmunoassay and radioreceptor assay. Thus no impairment was found in the GH-dependent SMA levels or the ability of hGH to generate somatomedin, which indicates that the growth retarding effect of cortisol is most likely due to a direct effect on the tissue. After treatment with stereotactic radiation to the hypophysis there was a significant decrease in cortisol excretion without any change in SMA levels, indicating the possibility to achieve a selective impairment of the ACTH-cortisol axis.

The effect of naloxone on ATCH and β-endorphin in patients with Cushing's disease

1985 ◽  
Vol 110 (2) ◽  
pp. 170-175 ◽  
Author(s):  
B. Baranowska ◽  
W. Dorobek ◽  
W. Misiorowski ◽  
W. Jeske ◽  
M. H. Abdel-Fattah
Keyword(s):  
Cushing’S Disease ◽  
Healthy Subjects ◽  
Opiate Receptor ◽  
Cushing's Disease ◽  
Receptor Blockade ◽  
Acth Secretion ◽  
Endogenous Opiates ◽  
Paradoxical Response ◽  
Cortisol Release ◽  
Serum Acth

Abstract. Endogenous opiates may be important in the control of ACTH secretion in men. The effect of opiate receptor blockade by naloxone on ACTH, β-endorphin-like substance and cortisol release was studied in healthy women and in 9 patients with Cushing's disease. In the healthy subjects, ACTH, β-endorphin and cortisol levels were increased in response to naloxone. However, in 3 our of the 9 patients with Cushing's disease, a paradoxical decrease in serum ACTH, cortisol and β-endorphin concentrations was observed after naloxone administration. In the patients with a paradoxical response to naloxone, transsphenoidal microadenomectomy was ineffective.

scholarly journals Voxel-based comparison of brain glucose metabolism between patients with Cushing's disease and healthy subjects

2018 ◽  
Vol 17 ◽  
pp. 354-358 ◽  
Author(s):  
Shuai Liu ◽  
Yinyan Wang ◽  
Kaibin Xu ◽  
Fan Ping ◽  
Fang Li ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Cushing’S Disease ◽  
Healthy Subjects ◽  
Cushing's Disease ◽  
Brain Glucose ◽  
Brain Glucose Metabolism

Abstract #825 Psychosis in Cushing’s Disease Treated with Etomidate

2018 ◽  
Vol 24 ◽  
pp. 185-186
Author(s):  
Sydney Blount ◽  
Marie Caldwell
Keyword(s):  
Cushing’S Disease ◽  
Cushing's Disease

Abstract #762: Treatment of Recurrent Cushing’s Disease

2005 ◽  
Vol 11 ◽  
pp. 54-55
Author(s):  
Daniel K. Short ◽  
William F. Young
Keyword(s):  
Cushing’S Disease ◽  
Cushing's Disease
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