Possible Human Leukocyte Antigen-Mediated Genetic Interaction between Type 1 and Type 2 Diabetes

2001 ◽  
Vol 86 (2) ◽  
pp. 574-582 ◽  
Author(s):  
H. Li
Keyword(s):  
Type 2 Diabetes ◽  
Human Leukocyte Antigen ◽  
Genetic Interaction ◽  
Human Leukocyte ◽  
Leukocyte Antigen

scholarly journals Susceptible and Protective Human Leukocyte Antigen Class II Alleles and Haplotypes in Bahraini Type 2 (Non-Insulin-Dependent) Diabetes Mellitus Patients

2005 ◽  
Vol 12 (1) ◽  
pp. 213-217 ◽  
Author(s):  
Ayesha A. Motala ◽  
Marc Busson ◽  
Einas M. Al-Harbi ◽  
Manal A. A. Khuzam ◽  
Emtiaz M. D. Al-Omari ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Type 1 Diabetes ◽  
Human Leukocyte Antigen ◽  
Human Leukocyte ◽  
Class Ii ◽  
Hla Class Ii ◽  
Leukocyte Antigen ◽  
Insulin Dependent

ABSTRACT Whereas the genetic risk for type 1 diabetes is linked to human leukocyte antigen (HLA) class II genes, the HLA association in type 2 (non-insulin-dependent) diabetes is less clear. The association between HLA class II genotypes and type 2 diabetes was examined in adult Bahrainis, an Arab population with a high prevalence of type 2 diabetes. HLA-DRB1* and -DQB1* genotyping of 86 unrelated type 2 diabetes patients (age, 51.6 ± 8.2 years; mean duration of diabetes, 7.7 ± 7.1 years) who had a strong family history of diabetes (52 of 72 versus 0 of 89 for controls, P < 0.001) and 89 healthy subjects was done by PCR-sequence-specific priming. DRB1*040101 (0.1221 versus 0.0562, P = 0.019) and DRB1*070101 (0.2151 versus 0.0843, P < 0.001) were positively associated, while DRB1*110101 (0.0698 versus 0.1461, P = 0.014) and DRB1*160101 (0.0640 versus 0.1236, P = 0.038) were negatively associated with type 2 diabetes. DRB1*040101-DQB1*0302 (0.069 versus 0.0007; P = 0.004), DRB1*070101-DQB1*0201 (0.178 versus 0.0761, P = 0.007), DRB1*070101-DQB1*050101 (0.125 versus 0.0310, P = 0.002), and DRB1*150101-DQB1*060101 (0.0756 versus 0.0281, P = 0.008) were more prevalent among patients, while DRB1*160101-DQB1*050101 (0.0702 versus 0.0349, P = 0.05) was more prevalent among controls, conferring disease susceptibility or protection, respectively. In Bahrainis with type 2 diabetes, there is a significant association with select HLA class II genotypes, which were distinct from those in type 1 diabetes.

scholarly journals Possible Human Leukocyte Antigen-Mediated Genetic Interaction between Type 1 and Type 2 Diabetes1

2001 ◽  
Vol 86 (2) ◽  
pp. 574-582 ◽  
Author(s):  
Haiyan Li ◽  
Eero Lindholm ◽  
Peter Almgren ◽  
Åsa Gustafsson ◽  
Carol Forsblom ◽  
...  
Keyword(s):  
Human Leukocyte Antigen ◽  
Genetic Interaction ◽  
Human Leukocyte ◽  
Leukocyte Antigen

Neurocognition, sleep, and PET findings in type 2 vs type 1 narcolepsy

Neurology ◽  
2018 ◽  
Vol 90 (17) ◽  
pp. e1478-e1487 ◽  
Author(s):  
Yu-Shu Huang ◽  
Ing-Tsung Hsiao ◽  
Feng-Yuan Liu ◽  
Fang-Ming Hwang ◽  
Kuang-Lin Lin ◽  
...  
Keyword(s):  
Human Leukocyte Antigen ◽  
Fdg Pet ◽  
Human Leukocyte ◽  
Functional Brain Imaging ◽  
Angular Gyrus ◽  
Brain Images ◽  
Functional Brain ◽  
Leukocyte Antigen

ObjectiveTo analyze differences in functional brain images collected in patients with type 2 and type 1 narcolepsy compared to normal controls and the relationship among brain images, objective neuropsychologic tests, and sleep findings.MethodsData collection included comprehensive clinical investigation, study of sleep/wake with actigraphy, polysomnography, Multiple Sleep Latency Test, human leukocyte antigen typing, 18F-fluorodeoxyglucose PET, and cognitive tests obtained from 29 patients with type 2 narcolepsy, 104 patients with type 1 narcolepsy, and 26 sex- and age-matched normal control individuals. Conners’ Continuous Performance Test (CPT II) and Wisconsin Card-Sorting Task were performed simultaneously with the FDG-PET examination. After analyses of variance, data between patients with type 1 and type 2 narcolepsy were compared by post hoc analysis, and correlation between functional brain imaging findings and results of neurocognitive tests was obtained.ResultsAll patients with narcolepsy presented with at least 2 sleep-onset REM periods (SOREMP) and subjective sleepiness. Patients with type 2 narcolepsy compared to patients with type 1 narcolepsy had significantly less SOREMP, longer mean sleep latencies, and lower body mass indexes, apnea-hypopnea indexes, and frequency of human leukocyte antigen DQ-Beta1*0602. In patients with type 2 narcolepsy, FDG-PET studies showed significantly less hypermetabolism in the fusiform gyrus, striatum, hippocampus, thalamus, basal ganglia, and cerebellum than in patients with type 1 narcolepsy, and significantly less hypometabolism in the regions of frontal lobe, posterior cingulum, angular gyrus, and part of the parietal lobe; these changes were associated with fewer errors on the CPT.ConclusionYoung patients with type 2 narcolepsy have fewer clinical impairments and less distinct brain functional abnormalities than patients with type 1 narcolepsy, who are significantly more affected.

Association of Anti-Human Leukocyte Antigen and Anti-Angiotensin II Type 1 Receptor Antibodies With Liver Allograft Fibrosis After Immunosuppression Withdrawal

2014 ◽  
Vol 98 (10) ◽  
pp. 1105-1111 ◽  
Author(s):  
Hidenori Ohe ◽  
Yoichiro Uchida ◽  
Atsushi Yoshizawa ◽  
Hirofumi Hirao ◽  
Michiko Taniguchi ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Human Leukocyte Antigen ◽  
Human Leukocyte ◽  
Liver Allograft ◽  
Leukocyte Antigen ◽  
Receptor Antibodies

scholarly journals Human Leukocyte Antigen B58 Supertype and Human Immunodeficiency Virus Type 1 Infection in Native Africans

2006 ◽  
Vol 80 (12) ◽  
pp. 6056-6060 ◽  
Author(s):  
Aleksandr Lazaryan ◽  
Elena Lobashevsky ◽  
Joseph Mulenga ◽  
Etienne Karita ◽  
Susan Allen ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Human Leukocyte Antigen ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Human Leukocyte ◽  
Subtype C ◽  
Leukocyte Antigen ◽  
Immunodeficiency Virus ◽  
Hiv 1

ABSTRACT Human leukocyte antigen (HLA) class I alleles can be grouped into supertypes according to their shared peptide binding properties. We examined alleles of the HLA-B58 supertype (B58s) in treatment-naïve human immunodeficiency virus type 1 (HIV-1)-seropositive Africans (423 Zambians and 202 Rwandans). HLA-B and HLA-C alleles were resolved to four digits by a combination of molecular methods, and their respective associations with outcomes of HIV-1 infection were analyzed by statistical procedures appropriate for continuous or categorical data. The effects of the individual alleles on natural HIV-1 infection were heterogeneous. In HIV-1 subtype C-infected Zambians, the mean viral load (VL) was lower among B*5703 (P = 0.01) or B*5703-Cw*18 (P < 0.001) haplotype carriers and higher among B*5802 (P = 0.02) or B*5802-Cw*0602 (P = 0.03) carriers. The B*5801-Cw*03 haplotype showed an association with low VL (P = 0.05), whereas B*5801 as a whole did not. Rwandans with HIV-1 subtype A infection showed associations of B*5703 and B*5802 with slow (P = 0.06) and rapid (P = 0.003) disease progression, respectively. In neither population were B*1516-B*1517 alleles associated with more favorable responses. Overall, B58s alleles, individually or as part of an HLA-B-HLA-C haplotype, appeared to have a distinctive impact on HIV-1 infection among native Africans. As presently defined, B58s alleles cannot be considered uniformly protective against HIV/AIDS in every population.

scholarly journals Human Leukocyte Antigen (HLA) and Islet Autoantibodies Are Tools to Characterize Type 1 Diabetes in Arab Countries: Emphasis on Kuwait

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Mohamed Jahromi ◽  
Ebaa Al-Ozairi
Keyword(s):  
Type 1 Diabetes ◽  
Human Leukocyte Antigen ◽  
Incidence Rate ◽  
Disease Onset ◽  
Human Leukocyte ◽  
Arab Countries ◽  
World Health ◽  
Leukocyte Antigen ◽  
Prospective Longitudinal

The incidence rate of type 1 diabetes in Kuwait had been increasing exponentially and has doubled in children≤14 years old within almost two decades. Therefore, there is a dire need for a careful systematic familial cohort study. Several immunogenetic factors affect the pathogenesis of the disease. The human leukocyte antigen (HLA) accounts for the major genetic susceptibility to the disease. The triggering agents initiate disease onset by type 1 destruction of pancreatic β-cells. Both HLA and anti-islet antibodies can be used to characterize, predict susceptibility to the disease, innovate, or delay the β-cell destruction. Evidence from prospective longitudinal studies suggested that the underlying disease process represents a continuum that begins before the symptoms are clinically evident. Autoimmunity of the functional pancreatic β-cells results in symptomatic type 1 diabetes and lifelong insulin dependence. The autoantibodies against glutamic acid decarboxylase (GADA), insulinoma antigen-2 (IA-2A), insulin (IAA), and zinc transporter-8 (ZnT-8A) comprise the most reliable biomarkers for type 1 diabetes in both children and adults. Although Kuwait is the second among the top 10 countries with a high incidence rate of type 1 diabetes, there have been no proper diagnostic and prediction tools as per the World Health Organization. The Kuwaiti Type 1 Diabetes Study (KADS) was initiated to understand the disease pathogenesis as well as the HLA and anti-islet autoantibody profile of type 1 diabetes in Kuwait. Understanding the disease sequela in a homogenous gene pool and highly consanguineous population of Kuwaitis could help solve the challenges and pathogenesis, as well as hasten the prevention, of type 1 diabetes.

scholarly journals The Rising Incidence of Type 1 Diabetes Is Accounted for by Cases With Lower-Risk Human Leukocyte Antigen Genotypes

Diabetes Care ◽  
2008 ◽  
Vol 31 (8) ◽  
pp. 1546-1549 ◽  
Author(s):  
S. Fourlanos ◽  
M. D. Varney ◽  
B. D. Tait ◽  
G. Morahan ◽  
M. C. Honeyman ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Human Leukocyte Antigen ◽  
Lower Risk ◽  
Human Leukocyte ◽  
Leukocyte Antigen ◽  
Rising Incidence
Sign in / Sign up

Export Citation Format

Share Document