Anabolic effects of recombinant human growth hormone in patients with wasting associated with human immunodeficiency virus infection

1993 ◽  
Vol 77 (4) ◽  
pp. 956-962 ◽  
Author(s):  
K. Mulligan
Keyword(s):  
Growth Hormone ◽  
Human Immunodeficiency Virus ◽  
Virus Infection ◽  
Human Immunodeficiency Virus Infection ◽  
Human Growth Hormone ◽  
Recombinant Human Growth Hormone ◽  
Human Growth ◽  
Immunodeficiency Virus

scholarly journals Effect of recombinant human growth hormone on acute and chronic human immunodeficiency virus infection in vitro

Blood ◽  
1992 ◽  
Vol 79 (2) ◽  
pp. 467-472
Author(s):  
J Laurence ◽  
B Grimison ◽  
A Gonenne
Keyword(s):  
Growth Hormone ◽  
Human Immunodeficiency Virus ◽  
Viral Replication ◽  
Human Growth Hormone ◽  
Cellular Proliferation ◽  
Recombinant Human Growth Hormone ◽  
Human Growth ◽  
Immunodeficiency Virus ◽  
Hiv 1

Growth hormone (somatotropin) is a potent anabolic protein currently being evaluated clinically in cachexia associated with malignancy and human immunodeficiency virus (HIV) disease. Growth hormone can also lead to enhancement of lectin-mediated cellular proliferation, macrophage activation, and cytokine induction, events linked to induction of latent HIV in vitro. We thus explored the ability of recombinant human growth hormone (rhGH) to affect viral replication in acute and chronic HIV infection, and to alter transcription at the HIV- 1 long terminal repeat (LTR). A clone of promonocytic cells, chronically infected with HIV-1 and susceptible to viral induction by a variety of cytokines and protein kinase C activators, was unperturbed by rhGH used over broad concentrations (10 to 500 ng/mL) and time intervals. This unresponsiveness paralleled the lack of effect of rhGH on HIV-associated trans-activation in both monocytic and CD4+ T-cell lines. In contrast, rhGH enhanced viral replication in acutely infected peripheral blood mononuclear cells (PBMC) by twofold to 20-fold, albeit having no adverse effect on the antiviral efficacy of zidovudine (AZT). Augmentation of HIV growth correlated with stimulation of cellular DNA synthetic responses and an increase in tumor necrosis factor-alpha (TNF- alpha) secretion. These data are discussed in the context of ongoing clinical trials of rhGH in HIV-seropositive individuals with wasting syndromes.

scholarly journals Effect of recombinant human growth hormone on acute and chronic human immunodeficiency virus infection in vitro

Blood ◽  
1992 ◽  
Vol 79 (2) ◽  
pp. 467-472 ◽  
Author(s):  
J Laurence ◽  
B Grimison ◽  
A Gonenne
Keyword(s):  
Growth Hormone ◽  
Human Immunodeficiency Virus ◽  
Viral Replication ◽  
Human Growth Hormone ◽  
Cellular Proliferation ◽  
Recombinant Human Growth Hormone ◽  
Human Growth ◽  
Immunodeficiency Virus ◽  
Hiv 1

Abstract Growth hormone (somatotropin) is a potent anabolic protein currently being evaluated clinically in cachexia associated with malignancy and human immunodeficiency virus (HIV) disease. Growth hormone can also lead to enhancement of lectin-mediated cellular proliferation, macrophage activation, and cytokine induction, events linked to induction of latent HIV in vitro. We thus explored the ability of recombinant human growth hormone (rhGH) to affect viral replication in acute and chronic HIV infection, and to alter transcription at the HIV- 1 long terminal repeat (LTR). A clone of promonocytic cells, chronically infected with HIV-1 and susceptible to viral induction by a variety of cytokines and protein kinase C activators, was unperturbed by rhGH used over broad concentrations (10 to 500 ng/mL) and time intervals. This unresponsiveness paralleled the lack of effect of rhGH on HIV-associated trans-activation in both monocytic and CD4+ T-cell lines. In contrast, rhGH enhanced viral replication in acutely infected peripheral blood mononuclear cells (PBMC) by twofold to 20-fold, albeit having no adverse effect on the antiviral efficacy of zidovudine (AZT). Augmentation of HIV growth correlated with stimulation of cellular DNA synthetic responses and an increase in tumor necrosis factor-alpha (TNF- alpha) secretion. These data are discussed in the context of ongoing clinical trials of rhGH in HIV-seropositive individuals with wasting syndromes.

scholarly journals Lack of Effect of Recombinant Human Growth Hormone on the In Vitro Activities of Antiretroviral Drugs against Human Immunodeficiency Virus Type 1

2004 ◽  
Vol 48 (6) ◽  
pp. 2337-2340 ◽  
Author(s):  
Mark A Wainberg ◽  
Bluma G. Brenner ◽  
Eric Daar ◽  
Joseph M. Gertner ◽  
Clement Olivier ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Human Immunodeficiency Virus ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Human Growth Hormone ◽  
Recombinant Human Growth Hormone ◽  
Human Growth ◽  
Antiretroviral Drugs ◽  
Immunodeficiency Virus

ABSTRACT We studied the effects of recombinant human growth hormone (r-hGH) on human immunodeficiency virus type 1 replication by growing both wild-type and drug-resistant variants of virus in the presence of various concentrations of eight different antiretroviral drugs. r-hGH had no significant effect on either viral replication or the 50% inhibitory concentrations of these compounds.

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