Interrelation between plasma sex hormone-binding globulin and plasma insulin in healthy adult women: the telecom study

1993 ◽  
Vol 76 (2) ◽  
pp. 283-287 ◽  
Author(s):  
P. Preziosi
Keyword(s):  
Plasma Insulin ◽  
Healthy Adult ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Adult Women ◽  
Hormone Binding

scholarly journals Serum levels of sex hormone-binding globulin (SHBG) are not associated with lower levels of non-SHBG-bound testosterone in male newborns and healthy adult men.

2005 ◽  
Vol 62 (4) ◽  
pp. 498-503 ◽  
Author(s):  
Willem de Ronde ◽  
Yvonne T. van der Schouw ◽  
Frank H. Pierik ◽  
Huibert A. P. Pols ◽  
Majon Muller ◽  
...  
Keyword(s):  
Healthy Adult ◽  
Serum Levels ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
Adult Men

scholarly journals Testosterone, sex hormone-binding globulin and free androgen index among adult women: chronological and ovarian aging

2009 ◽  
Vol 24 (9) ◽  
pp. 2276-2285 ◽  
Author(s):  
M.F.R. Sowers ◽  
H. Zheng ◽  
D. McConnell ◽  
B. Nan ◽  
C.A. Karvonen-Gutierrez ◽  
...  
Keyword(s):  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Adult Women ◽  
Hormone Binding ◽  
Free Androgen Index ◽  
Ovarian Aging

scholarly journals Establishment of sex difference in circulating uric acid is associated with higher testosterone and lower sex hormone-binding globulin in adolescent boys

2021 ◽  
Author(s):  
Yutang Wang ◽  
Fadi J Charchar
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Sex Difference ◽  
Free Testosterone ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Adult Women ◽  
Inverse Association ◽  
Hormone Binding ◽  
Adolescent Boys

Abstract Men have higher circulating levels of uric acid than women. This sex difference is suspected to be a result of suppressive effects of estradiol on uric acid. If so, estradiol would be inversely associated with circulating uric acid. This study aimed to test this hypothesis. This cross-sectional study included 9 472 participants (weighted sample size of 184 342 210) aged 12–80 years from the 2013 to 2016 US National Health and Nutrition Examination Survey. Associations of sex hormones with uric acid were analyzed using weighted least squares regression, adjusting for demographic characteristics, lifestyle risk factors, and comorbidities. Neither free nor bioavailable estradiol was inversely associated with circulating uric acid in males or females or adolescents or adults or females around menopausal age (47–56 years). Log-transformed free testosterone was positively associated with serum uric acid in adolescent boys (β = 0.250, P < 0.001), girls (β = 0.159, P < 0.001), adult women (β = 0.131, P < 0.001) and women around menopausal age (β = 0.143, P < 0.001) after adjustment for all tested confounders. The results from bioavailable testosterone were similar to those from free testosterone. In addition, log-transformed sex hormone-binding globulin was inversely associated with serum uric acid in males (β=- 0.171, P < 0.001) and females (β=-0.181, P < 0.001) after adjustment for all tested confounders and the inverse association remained in all sub-cohorts. Moreover, sex difference in circulating uric acid was established during adolescence and this establishment coincided with a dramatic increase in testosterone and a dramatic decrease in sex hormone-binding globulin in boys. These results suggest that estradiol is not inversely associated with circulating uric acid and the establishment of sex difference in circulating uric acid is associated with higher testosterone and lower sex hormone-binding globulin in adolescent boys.

Effects of oestradiol on sex hormone binding globulin

1982 ◽  
Vol 101 (2) ◽  
pp. 248-253 ◽  
Author(s):  
Viveca Odlind ◽  
Kerstin Elamsson ◽  
Doris E. Englund ◽  
Arne Victor ◽  
Elof D. B. Johansson
Keyword(s):  
Luteal Phase ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
Pronounced Increase ◽  
Menstrual Cycles ◽  
Menopausal Women ◽  
Plasma Oestradiol

Abstract. Sex hormone binding globulin (SHBG) levels were studied for possible effects of oestradiol-17β on SHBG. No change in SHBG plasma was recorded during normal menstrual cycles or during treatment with oestradiol-17β to menopausal women. However, gonadotrophin treatment to amenorrhoeic women to induce ovulation resulted in high oestradiol concentrations and a pronounced increase in SHBG was found during the luteal phase of these cycles. A marked increase of SHBG was also recorded in a woman with pronounced fluctuations of oestradiol during treatment with levonorgestrel sc implants for contraception. In conclusion, effects on SHBG were only found when extraordinarily high levels of plasma oestradiol were recorded.

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