Long term follow-up of Cushing's disease treated with reserpine and pituitary irradiation

1992 ◽  
Vol 75 (3) ◽  
pp. 935-942 ◽  
Author(s):  
M. Murayama
Keyword(s):  
Cushing’S Disease ◽  
Cushing's Disease ◽  
Long Term Follow Up ◽  
Pituitary Irradiation

MEGAVOLTAGE PITUITARY IRRADIATION IN THE MANAGEMENT OF CUSHING'S DISEASE AND NELSON'S SYNDROME: LONG-TERM FOLLOW-UP

1989 ◽  
Vol 31 (3) ◽  
pp. 309-323 ◽  
Author(s):  
T. A. HOWLETT ◽  
P. N. PLOWMAN ◽  
J. A. H. WASS ◽  
L. H. REES ◽  
A. E. JONES ◽  
...  
Keyword(s):  
Cushing’S Disease ◽  
Cushing's Disease ◽  
Nelson’S Syndrome ◽  
Nelson's Syndrome ◽  
Long Term Follow Up ◽  
Pituitary Irradiation

Long Term Follow-up of Cushing's Disease Treated with Reserpine and Pituitary Irradiation Followed by Subtotal Adrenalectomy.

1994 ◽  
Vol 172 (2) ◽  
pp. 97-109
Author(s):  
MASANORI MURAYAMA ◽  
KEIGO YASUDA ◽  
YOSHIAKI MINAMORI ◽  
LEILANI B. MERCADO-ASIS ◽  
NORIYOSHI YAMAKITA ◽  
...  
Keyword(s):  
Cushing’S Disease ◽  
Cushing's Disease ◽  
Subtotal Adrenalectomy ◽  
Long Term Follow Up ◽  
Pituitary Irradiation

LONG-TERM FOLLOW-UP OF LOW-DOSE EXTERNAL PITUITARY IRRADIATION FOR CUSHING'S DISEASE

1990 ◽  
Vol 33 (4) ◽  
pp. 445-455 ◽  
Author(s):  
M. D. LITTLEY ◽  
S. M. SHALET ◽  
C. G. BEARDWELL ◽  
S. R. AHMED ◽  
M. L. SUTTON
Keyword(s):  
Cushing’S Disease ◽  
Low Dose ◽  
Cushing's Disease ◽  
Long Term Follow Up ◽  
Pituitary Irradiation

Long term follow-up of Cushing's disease treated with reserpine and pituitary irradiation.

1992 ◽  
Vol 75 (3) ◽  
pp. 935-942 ◽  
Author(s):  
M Murayama ◽  
K Yasuda ◽  
Y Minamori ◽  
L B Mercado-Asis ◽  
N Yamakita ◽  
...  
Keyword(s):  
Cushing’S Disease ◽  
Cushing's Disease ◽  
Long Term Follow Up ◽  
Pituitary Irradiation

scholarly journals Usefulness of the desmopressin test in the postoperative evaluation of patients with Cushing's disease

2000 ◽  
pp. 227-234 ◽  
Author(s):  
P Colombo ◽  
C Dall'Asta ◽  
L Barbetta ◽  
T Re ◽  
E Passini ◽  
...  
Keyword(s):  
Cushing’S Disease ◽  
Serum Cortisol ◽  
Cushing's Disease ◽  
Plasma Acth ◽  
Before And After ◽  
Long Term Follow Up ◽  
Cortisol Responses ◽  
Pituitary Irradiation

OBJECTIVE: To evaluate the plasma ACTH and serum cortisol responses to desmopressin in patients with Cushing's disease either before or after pituitary adenomectomy during long-term follow-up, and to compare the results with those obtained after corticotrophin-releasing hormone (CRH) testing. DESIGN: Plasma ACTH and serum cortisol concentrations were evaluated after the administration of desmopressin (10 microg i.v.) or CRH (1 microg/kg i. v.) in 34 patients with Cushing's disease. Twenty-four patients with active Cushing's disease were evaluated both before and after transsphenoidal pituitary surgery (TSS); these patients were followed up for 1-36 months. Ten patients were studied only after a long-term period (1-19 years, median 4 years) after TSS (six patients), TSS plus external pituitary irradiation (three patients) and TSS plus radiosurgery (one patient). RESULTS: In 24 patients with active Cushing's disease a significant ACTH/cortisol response (P<0.001) was induced by either desmopressin (ACTH from a baseline of 15.3+/-2.7 pmol/l to a peak of 40.9+/-7.3 pmol/l; cortisol from 673+/-59 nmol/l to 1171+/-90 nmol/l) or CRH (ACTH from a basal of 14. 2+/-2.5 pmol/l to a peak of 47.2+/-7.7 pmol/l; cortisol from 672+/-50 nmol/l to 1192+/- 80 nmol/l). In all patients a positive cortisol response to desmopressin was found. After pituitary adenomectomy the 14 'cured' patients were followed up for 1-36 months; desmopressin administration never induced ACTH or cortisol responsiveness in any patient. In contrast, a progressive recovery of ACTH and cortisol responses after CRH was observed at different intervals of time in all patients but one. Five patients, in whom the cortisol concentration only normalized after surgery, showed a persistent responsiveness to desmopressin, and two of them relapsed 12 and 24 months later. In five patients who were not cured, the hormonal responsiveness to either CRH or desmopressin was similar before and after operation. Of 10 patients studied only after long-term follow-up, six were cured and a normal response to CRH was present, whereas no changes in ACTH/cortisol concentrations were induced by desmopressin. The other four unsuccessfully operated patients underwent pituitary irradiation and showed different and equivocal hormonal responses to desmopressin and to CRH. CONCLUSIONS: During the postoperative follow-up of patients with Cushing's disease, the maintenance or the disappearance of the hormonal response may be related to the persistence or the complete removal of adenomatous corticotrophs, respectively. It is suggested that desmopressin test should be performed in the preoperative evaluation and follow-up of patients with ACTH-dependent Cushing's syndrome.

Long term follow-up of transsphenoidal surgery for the treatment of Cushing's disease in childhood.

1995 ◽  
Vol 80 (8) ◽  
pp. 2475-2479 ◽  
Author(s):  
M C Leinung ◽  
L A Kane ◽  
B W Scheithauer ◽  
P C Carpenter ◽  
E R Laws ◽  
...  
Keyword(s):  
Cushing’S Disease ◽  
Transsphenoidal Surgery ◽  
Cushing's Disease ◽  
Long Term Follow Up

Results of repeated transsphenoidal surgery in Cushing's disease. Long-term follow-up

2014 ◽  
Vol 61 (4) ◽  
pp. 176-183 ◽  
Author(s):  
Pablo Valderrábano ◽  
Javier Aller ◽  
Leopoldo García-Valdecasas ◽  
José García-Uría ◽  
Laura Martín ◽  
...  
Keyword(s):  
Cushing’S Disease ◽  
Transsphenoidal Surgery ◽  
Cushing's Disease ◽  
Long Term Follow Up
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