Assessment of growth hormone (GH) axis in Turner's syndrome using 24- hour integrated concentrations of GH, insulin-like growth factor-I, plasma GH-binding activity, GH binding to IM9 cells, and GH response to pharmacological stimulation

1992 ◽  
Vol 75 (2) ◽  
pp. 412-416 ◽  
Author(s):  
Z. Zadik
Keyword(s):  
Growth Hormone ◽  
Growth Factor ◽  
Binding Activity ◽  
Turner's Syndrome ◽  
Insulin Like Growth Factor ◽  
Turner’S Syndrome ◽  
Factor I ◽  
Pharmacological Stimulation ◽  
Growth Factor I ◽  
Plasma Gh

Growth Hormone and Craniofacial Changes: Preliminary Data From Studies in Turner's Syndrome

PEDIATRICS ◽  
1999 ◽  
Vol 104 (Supplement_5) ◽  
pp. 1021-1024
Author(s):  
Kirt E. Simmons
Keyword(s):  
Growth Hormone ◽  
Growth Factor ◽  
Dental Development ◽  
Turner's Syndrome ◽  
Craniofacial Growth ◽  
Insulin Like Growth Factor ◽  
Turner’S Syndrome ◽  
Mandibular Growth ◽  
Factor I ◽  
Control Subjects

Normal craniofacial and dental growth and development is dependent on growth hormone (GH) and insulin-like growth factor I (IGF-I). Deficiencies of either during childhood cause diminished growth of the maxilla and (to a greater degree) the mandible. Dental development/eruption also is compromised. Conversely, excessive GH/insulin-like growth factor I causes overgrowth, with the mandible again more affected than the maxilla. Replacement therapy in deficiency conditions generally normalizes craniofacial growth. Systemic GH also has been used in other disorders for which overt deficiency of GH has not been demonstrated. One such condition, Turner's syndrome, is now widely treated with GH. Although systemic GH in Turner's syndrome has been shown to positively affect stature, the effects on craniofacial growth and dental development/eruption are largely unknown. To explore these issues, standardized lateral radiographs of seven untreated patients with Turner's syndrome were analyzed and revealed hypoplasias of the cranial base, maxilla, and mandible. Dental development/eruption of patients with Turner's syndrome was found to be significantly advanced (by 0.63 years), relative to control subjects, in a separate study. Annual radiocephalometric measurements of 19 patients with Turner's syndrome treated with GH were compared with nonaffected control subjects over 1 year of treatment. Compared with age-matched historic control subjects, all maxillary—and most mandibular—growth measures were within 2 standard deviations of control. However, in our patients with Turner's syndrome, we found two measures of mandibular growth that deviated by more than 3 standard deviations from control. These data, although preliminary and only encompassing a short period, indicate that mandibular growth may be more affected than is maxillary growth by GH treatment and should be monitored over long-term-therapy.

Insulin-like growth factor I and growth hormone in canine starvation

1985 ◽  
Vol 108 (2) ◽  
pp. 161-166 ◽  
Author(s):  
J. Eugen Eigenmann ◽  
Jan. J. de Bruijne ◽  
E. Rudolf Froesch
Keyword(s):  
Growth Hormone ◽  
Growth Factor ◽  
Insulin Like Growth Factor ◽  
Drastic Reduction ◽  
Factor I ◽  
Igf I ◽  
Growth Factor I ◽  
Plasma Gh ◽  
Circulating Levels ◽  
Secretory Capacity

Abstract. The roles of plasma insulin-like growth factor I (IGF I) and growth hormone (GH) were studied in 7 beagle dogs before and during starvation and during refeeding. IGF I levels significantly decreased from 75.2 ± 5.9 ng/ml at 7 days prior to the start of starvation to 9 ± 1.7 ng/ml at 19 days after the commencement of starvation (mean ± sem; P < 0.0001). During refeeding IGF I significantly rose from 9 ± 1.7 ng/ml to 55.5 ± 7.5 ng/ml within 9 days (mean ± sem; P < 0.002). During starvation plasma GH levels significantly increased (P < 0.05) and these elevated levels returned to normal during refeeding. The dogs' GH secretory capacity significantly increased during starvation (P = 0.012) and became normal again during refeeding. The following conclusions can be drawn from this study: 1) starvation in the dog leads to a significant and drastic reduction of the circulating levels of IGF I, and 2) starvation in the dog, as in man, leads to increased circulating GH levels and to an increased GH-secretory capacity possibly brought about by a lack of a negative feedback normally exerted by IGF I.

Sign in / Sign up

Export Citation Format

Share Document