Hypothalamo-pituitary axis by magnetic resonance imaging in isolated growth hormone deficiency patients born by normal delivery

1992 ◽  
Vol 74 (3) ◽  
pp. 654-659 ◽  
Author(s):  
R. Marwaha
Keyword(s):  
Magnetic Resonance Imaging ◽  
Growth Hormone ◽  
Magnetic Resonance ◽  
Growth Hormone Deficiency ◽  
Hormone Deficiency ◽  
Resonance Imaging ◽  
Normal Delivery ◽  
Isolated Growth Hormone Deficiency

Questioning the Value of Brain Magnetic Resonance Imaging in the Evaluation of Children with Isolated Growth Hormone Deficiency

2020 ◽  
Vol 93 (4) ◽  
pp. 245-250
Author(s):  
Asaf Oren ◽  
Dana Singer ◽  
Marianna Rachmiel ◽  
Uri  Hamiel ◽  
Shelly I. Shiran ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Growth Hormone ◽  
Magnetic Resonance ◽  
Growth Hormone Deficiency ◽  
Brain Mri ◽  
Brain Magnetic Resonance Imaging ◽  
Hormone Deficiency ◽  
Resonance Imaging ◽  
Isolated Growth Hormone Deficiency ◽  
The Mean

<b><i>Background:</i></b> Isolated growth hormone deficiency (IGHD) is a relatively common disorder. Current diagnostic protocol requires a brain magnetic resonance imaging (MRI) study of the hypothalamus and the hypophysis to determine the cause after establishment of the diagnosis. This study aimed to examine the yield of brain MRI in the evaluation of children with IGHD and to define clinical and laboratory parameters that justify its performance. <b><i>Methods:</i></b> A retrospective chart review of all children (&#x3c;18 years) diagnosed with IGHD was conducted at 3 pediatric endocrinology units between 2008 and 2018. <b><i>Results:</i></b> The study included 192 children (107 boys) with confirmed IGHD. The mean age ± standard deviation (SD) at diagnosis was 8.2 ± 3.7 years (median 8.5 years, range 0.8–15.9). The mean height SD score (SDS) at diagnosis was –2.25 ± 0.73. The mean height deficit SDS (defined as the difference between height SDS at diagnosis and mid-parental height SDS) was –1.7 ± 0.9. Fifteen children (7.8%) had pathological MRI findings. No space-occupying lesion was detected. Children with pathological MRIs had greater height deficit SDS and lower peak growth hormone levels on provocative tests compared to children with normal MRIs: –2.3 ± 1.2 vs. –1.6 ± 0.8 (<i>p</i> = 0.02) and 4.4 ± 1.9 vs. 5.7 ± 1.3 (<i>p</i> = 0.01), respectively. <b><i>Conclusion:</i></b> Our preliminary data indicate that most brain MRIs performed for routine evaluation of children with IGHD are not essential for determining cause. Further studies with larger cohorts are needed in order to validate this proposed revision of current protocols.

scholarly journals Extrapontine Myelinolysis following Extreme Hypernatremia and Hyperosmolarity

2019 ◽  
Vol 2019 ◽  
pp. 1-5
Author(s):  
Jan-Niclas Schwade ◽  
Lior Haftel ◽  
Lars Rühe ◽  
Matthias Endmann
Keyword(s):  
Magnetic Resonance Imaging ◽  
Growth Hormone ◽  
Magnetic Resonance ◽  
Growth Hormone Deficiency ◽  
Medical History ◽  
Hormone Deficiency ◽  
Resonance Imaging ◽  
Cranial Magnetic Resonance Imaging ◽  
Extrapontine Myelinolysis ◽  
Therapeutic Implications

We present a case of a nearly 3-year-old girl who was admitted to hospital due to severe hypernatremia (196 mmol/l). Her medical history included central hypothyreosis and growth hormone deficiency. Rehydration and normalization of sodium was achieved according to guidelines. On the fourth day of hospitalization, the patient developed tremor, ataxia, and rigor. Cranial magnetic resonance imaging (cMRI) was performed and (mis)interpreted for meningoencephalitis, with corresponding diagnostic and therapeutic implications. The patient had extrapontine myelinolysis. The child recovered completely after hospitalization for nearly 2 weeks.

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