Hair growth effects of oral administration of finasteride, a steroid 5 alpha-reductase inhibitor, alone and in combination with topical minoxidil in the balding stumptail macaque

1992 ◽  
Vol 74 (2) ◽  
pp. 345-350 ◽  
Author(s):  
A. R. Diani
Keyword(s):  
Oral Administration ◽  
Hair Growth ◽  
Reductase Inhibitor ◽  
Growth Effects ◽  
Stumptail Macaque ◽  
Topical Minoxidil

scholarly journals A Mixture of Tocopherol Acetate and L-Menthol Synergistically Promotes Hair Growth in C57BL/6 Mice

Pharmaceutics ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 1234
Author(s):  
Seunghyun Ahn ◽  
Jung Yeon Lee ◽  
Sang Mi Choi ◽  
Yujeong Shin ◽  
Seyeon Park
Keyword(s):  
Hair Growth ◽  
Dorsal Side ◽  
In Vivo Experiments ◽  
Forkhead Box ◽  
Tocopherol Acetate ◽  
The Us ◽  
Topical Minoxidil ◽  
Fibroblast Growth Factor 10 ◽  
Us Fda

Oral finasteride and topical minoxidil are single components approved by the US FDA for treating hair loss. Some other compounds originating from natural products are also traditionally used for promoting hair growth. In this study, observations of treated keratinocyte cells were used to demonstrate that tocopherol acetate, L-menthol, and stevioside exert an effect on cell regeneration. Furthermore, these were topically applied to the shaved skin of C57BL/6 mice to observe their effects on hair growth. A mixture of tocopherol acetate, L-menthol, and stevioside showed the highest potential for promoting hair growth in vivo. In in vivo experiments, the mixture of tocopherol acetate, L-menthol, and stevioside was more effective than tocopherol acetate or L-menthol alone in promoting hair growth. The transcriptome analysis of skin from the dorsal side of a mouse treated with tocopherol acetate or L-menthol versus vehicle revealed key changes in keratin, keratin-associated protein, forkhead box, sonic hedgehog, fibroblast growth factor 10, desmoglein 4, deoxyribonuclease 1-like 2, and cadherin 3, known to play roles in promoting hair growth.

scholarly journals A Multimodal Hair-Loss Treatment Strategy Using a New Topical Phytoactive Formulation: A Report of Five Cases

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Sanusi Umar ◽  
Marissa J. Carter
Keyword(s):  
Side Effects ◽  
Hair Loss ◽  
Hair Growth ◽  
Case Series ◽  
Previous Treatment ◽  
Case Presentation ◽  
Topical Minoxidil ◽  
Continued Use ◽  
New Formulation ◽  
Infant Stage

Introduction. Current approved medications for hair loss, such as topical minoxidil and oral finasteride, may have suboptimal efficacy or side effects precluding continued use in some patients. Thus, we report an evaluation of the efficacy, safety, and tolerability of a new topical botanical formulation -GASHEE containing over 12 phytoactive ingredients that affect multiple targets in the cascade of pathophysiologic events that cause hair loss. Five patients with various hair-loss conditions, including cases of previous treatment failures, are presented. Case Presentation. This is a case series of four women and one man with hair loss due to various causes, four of whom had failed minoxidil treatment for over a year. All patients used the topical treatment as a sole therapy for at least 3 months before the documentation of outcomes, which involved interval changes noted through each patient’s account, direct observation, and photography. Discussion. In all patients, we observed significant improvements in hair regrowth in the nape, crown, vertex, and temple areas after 3–15 months of treatment. All patients were highly satisfied with their results and reported no adverse events. Although the use of botanicals in the treatment of hair loss is in an infant stage, the new formulation used in this study demonstrated a good efficacy related to hair growth, warranting further evaluation.

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