No Beneficial Effects of Resveratrol on the Metabolic Syndrome: A Randomized Placebo-Controlled Clinical Trial

AbstractBeneficial effects of probiotics have been reported on body weight, lipid and carbohydrate metabolism, inflammatory state and oxidative stress in healthy subjects and in many metabolic and inflammatory diseases. The aim of this study was to evaluate the effects ofBifidobacterium lactisHN019 on inflammatory state and nitro-oxidative stress in patients with and without the metabolic syndrome (MetS). The usual diets of the thirty-three subjects were supplemented with probiotic milk for 90 d. Inflammatory markers and oxidative measurements were performed. In relation to the baseline values, subjects in both groups showed a decrease in homocysteine (P=0·02 andP=0·03, respectively), hydroperoxides (P=0·02 andP=0·01, respectively) and IL-6 levels (P=0·02). Increases in adiponectin (P=0·04) and nitric oxide metabolites (NOx,P=0·001) levels were only seen in the group with the MetS in relation to the baseline values, whereas only the individuals without the MetS had increases in total radical-trapping antioxidant parameter levels (P=0·002). In conclusion,B. lactisHN019 have several beneficial effects on inflammatory and oxidative biomarkers in healthy subjects and the MetS patients. Patients with the MetS showed a specific improvement in adiponectin and NOx levels, whereas a specific favourable effect was shown in the antioxidant defenses in healthy subjects. If the results obtained in the present study are confirmed, supplementation of fermented milk with probiotics in healthy subjects and patients with the MetS must be further discussed.

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Ketone Ester Effects on Biomarkers of Brain Metabolism and Cognitive Performance in Cognitively Intact Adults ≥ 55 Years Old. A Study Protocol for a Double-Blinded Randomized Controlled Clinical Trial

Journal of Prevention of Alzheimer's Disease ◽

10.14283/jpad.2022.3 ◽

2022 ◽

pp. 1-12

Author(s):

K.I. Avgerinos ◽

R.J. Mullins ◽

J.M. Egan ◽

D. Kapogiannis

Keyword(s):

Metabolic Syndrome ◽

Clinical Trial ◽

Cognitive Performance ◽

Animal Studies ◽

Brain Metabolism ◽

Ketone Bodies ◽

Controlled Clinical Trial ◽

Resonance Spectroscopy ◽

Double Blinded ◽

Cognitively Intact

BACKGROUND: Ketone bodies have been proposed as an “energy rescue” for the Alzheimer’s disease (AD) brain, which underutilizes glucose. Prior research has shown that oral ketone monoester (KME) safely induces robust ketosis in humans and has demonstrated cognitive-enhancing and pathology-reducing properties in animal models of AD. However, human evidence that KME may enhance brain ketone metabolism, improve cognitive performance and engage AD pathogenic cascades is scarce. Objectives: To investigate the effects of ketone monoester (KME) on brain metabolism, cognitive performance and AD pathogenic cascades in cognitively normal older adults with metabolic syndrome and therefore at higher risk for AD. Design: Double-blinded randomized placebo-controlled clinical trial. Setting: Clinical Unit of the National Institute on Aging, Baltimore, US. Participants: Fifty cognitively intact adults ≥ 55 years old, with metabolic syndrome. Intervention: Drinks containing 25 g of KME or isocaloric placebo consumed three times daily for 28 days. Outcomes: Primary: concentration of beta-hydroxybutyrate (BHB) in precuneus measured with Magnetic Resonance Spectroscopy (MRS). Exploratory: plasma and urine BHB, multiple brain and muscle metabolites detected with MRS, cognition assessed with the PACC and NIH toolbox, biomarkers of AD and metabolic mediators in plasma extracellular vesicles, and stool microbiome. Discussion: This is the first study to investigate the AD-biomarker and cognitive effects of KME in humans. Ketone monoester is safe, tolerable, induces robust ketosis, and animal studies indicate that it can modify AD pathology. By conducting a study of KME in a population at risk for AD, we hope to bridge the existing gap between pre-clinical evidence and the potential for brain-metabolic, pro-cognitive, and anti-Alzheimer’s effects in humans.

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The effect of cumin supplementation on metabolic profiles in patients with metabolic syndrome: A randomized, triple blind, placebo‐controlled clinical trial

Phytotherapy Research ◽

10.1002/ptr.6313 ◽

2019 ◽

Vol 33 (4) ◽

pp. 1182-1190 ◽

Cited By ~ 3

Author(s):

Ashti Morovati ◽

Bahram Pourghassem Gargari ◽

Parvin Sarbakhsh ◽

Hushyar Azari ◽

Lida Lotfi‐Dizaji

Keyword(s):

Metabolic Syndrome ◽

Clinical Trial ◽

Controlled Clinical Trial ◽

Metabolic Profiles

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The beneficial effects of therapeutic craniofacial massage on quality of life, mental health and menopausal symptoms and body image: A randomized controlled clinical trial

Complementary Therapies in Medicine ◽

10.1016/j.ctim.2020.102415 ◽

2020 ◽

Vol 51 ◽

pp. 102415

Author(s):

Gemma V. Espí-López ◽

Lucas Monzani ◽

Elena Gabaldón-García ◽

Rosario Zurriaga

Keyword(s):

Quality Of Life ◽

Mental Health ◽

Clinical Trial ◽

Body Image ◽

Menopausal Symptoms ◽

Controlled Clinical Trial ◽

Randomized Controlled Clinical Trial ◽

Beneficial Effects ◽

Randomized Controlled

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Exercise Induced Adipokine Changes and the Metabolic Syndrome

Journal of Diabetes Research ◽

10.1155/2014/726861 ◽

2014 ◽

Vol 2014 ◽

pp. 1-16 ◽

Cited By ~ 71

Author(s):

Saeid Golbidi ◽

Ismail Laher

Keyword(s):

Physical Activity ◽

Insulin Resistance ◽

Metabolic Syndrome ◽

Adipose Tissue ◽

The Body ◽

Beneficial Effects ◽

The Metabolic Syndrome ◽

Before And After ◽

Inflammatory State ◽

Exercise Induced

The lack of adequate physical activity and obesity created a worldwide pandemic. Obesity is characterized by the deposition of adipose tissue in various parts of the body; it is now evident that adipose tissue also acts as an endocrine organ capable of secreting many cytokines that are though to be involved in the pathophysiology of obesity, insulin resistance, and metabolic syndrome. Adipokines, or adipose tissue-derived proteins, play a pivotal role in this scenario. Increased secretion of proinflammatory adipokines leads to a chronic inflammatory state that is accompanied by insulin resistance and glucose intolerance. Lifestyle change in terms of increased physical activity and exercise is the best nonpharmacological treatment for obesity since these can reduce insulin resistance, counteract the inflammatory state, and improve the lipid profile. There is growing evidence that exercise exerts its beneficial effects partly through alterations in the adipokine profile; that is, exercise increases secretion of anti-inflammatory adipokines and reduces proinflammatory cytokines. In this paper we briefly describe the pathophysiologic role of four important adipokines (adiponectin, leptin, TNF-α, and IL-6) in the metabolic syndrome and review some of the clinical trials that monitored these adipokines as a clinical outcome before and after exercise.

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Effects of Periodontal Therapy on Systemic Markers of Inflammation in Patients With Metabolic Syndrome: A Controlled Clinical Trial

Journal of Periodontology ◽

10.1902/jop.2011.110227 ◽

2012 ◽

Vol 83 (3) ◽

pp. 267-278 ◽

Cited By ~ 49

Author(s):

Néstor J. López ◽

Antonio Quintero ◽

Patricia A. Casanova ◽

Carola I. Ibieta ◽

Vibeke Baelum ◽

...

Keyword(s):

Metabolic Syndrome ◽

Clinical Trial ◽

Periodontal Therapy ◽

Controlled Clinical Trial ◽

Markers Of Inflammation

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Blueberries Improve Endothelial Function, but Not Blood Pressure, in Adults with Metabolic Syndrome: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Nutrients ◽

10.3390/nu7064107 ◽

2015 ◽

Vol 7 (6) ◽

pp. 4107-4123 ◽

Cited By ~ 68

Author(s):

April Stull ◽

Katherine Cash ◽

Catherine Champagne ◽

Alok Gupta ◽

Raymond Boston ◽

...

Keyword(s):

Blood Pressure ◽

Metabolic Syndrome ◽

Clinical Trial ◽

Endothelial Function ◽

Controlled Clinical Trial ◽

Double Blind ◽

Double Blind Placebo

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Effect of Keishibukuryogan on Endothelial Function in Patients with at Least One Component of the Diagnostic Criteria for Metabolic Syndrome: A Controlled Clinical Trial with Crossover Design

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2012/359282 ◽

2012 ◽

Vol 2012 ◽

pp. 1-10 ◽

Cited By ~ 16

Author(s):

Yutaka Nagata ◽

Hirozo Goto ◽

Hiroaki Hikiami ◽

Tatsuya Nogami ◽

Makoto Fujimoto ◽

...

Keyword(s):

Metabolic Syndrome ◽

Clinical Trial ◽

Endothelial Function ◽

Reactive Hyperemia ◽

Control Period ◽

Crossover Design ◽

Controlled Clinical Trial ◽

Related Factors ◽

Group A ◽

Group B

We evaluated the effect of keishibukuryogan (KBG; Guizhi-Fuling-Wan), a traditional Japanese (Kampo) formula, on endothelial function assessed by reactive hyperemia peripheral arterial tonometry (Endo-PAT2000) in patients with metabolic syndrome-related factors by controlled clinical trial with crossover design. Ninety-two patients were assigned to group A (first KBG-treatment period, then control period; each lasting 4 weeks, with about one-year interval) or group B (first control, then KBG-treatment). In forty-nine (27, group A; 22, group B) patients completing all tests, the mean value of the natural logarithmic-scaled reactive hyperemia index (L_RHI) increased and those of serum nonesterified fatty acid (NEFA), malondialdehyde, and soluble vascular cell adhesion molecule 1 decreased significantly during the KBG-treatment period, but not during the control period, and 4-week changes of L_RHI, NEFA, and malondialdehyde between the 2 periods showed significance. These results suggest that KBG has beneficial effect on endothelial function in patients with metabolic syndrome-related factors.

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