scholarly journals Arginase Inhibition Improves Microvascular Endothelial Function in Patients With Type 2 Diabetes Mellitus

2016 ◽  
Vol 101 (11) ◽  
pp. 3952-3958 ◽  
Author(s):  
Oskar Kövamees ◽  
Alexey Shemyakin ◽  
Antonio Checa ◽  
Craig E. Wheelock ◽  
Jon O. Lundberg ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Endothelial Function ◽  
Microvascular Endothelial ◽  
Microvascular Endothelial Function

scholarly journals Changes in endothelial function during educational hospitalization and the contributor to improvement of endothelial function in type 2 diabetes mellitus

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Yukiko Goshima ◽  
Yosuke Okada ◽  
Keiichi Torimoto ◽  
Yoshihisa Fujino ◽  
Yoshiya Tanaka
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Endothelial Function ◽  
Multivariable Analysis ◽  
Vascular Endothelial ◽  
Single Factor ◽  
Vascular Endothelial Function ◽  
Before And After

Abstract Only a few reports have examined vascular endothelial function before and after educational hospitalization and the factors that affect it in patients with type 2 diabetes mellitus (T2DM). The aim of this study was to assess vascular endothelial function before and after educational hospitalization and identify factors that affect it. In 65 patients with T2DM who underwent peripheral arterial tonometry (EndoPAT) before and after hospitalization, vascular endothelial function (reactive hyperemia index [RHI]), glucose metabolism, lipid metabolism, and blood pressure were assessed before and after hospitalization. The primary endpoint was hospitalization-induced changes in vascular endothelial function. Educational hospitalization significantly improved the natural logarithmically scaled RHI (L_RHI) from 0.555 ± 0.212 to 0.625 ± 0.245 (p = 0.012). Multivariable logistic regression analysis identified hypoglycemia during hospitalization as the single factor that significantly altered vascular endothelial function (p = 0.019). The odds of achieving normal vascular endothelial function were 0.08 times lower (95% confidence interval, 0.01–0.67) for each episode of hypoglycemia. Furthermore, multivariable analysis identified hypoglycemia during hospitalization as the single factor that worsened L_RHI. Our study showed that educational hospitalization of patients with T2DM improved vascular endothelial function, and that the development of hypoglycemic episodes had a significant negative impact on normalization of vascular endothelial function.

scholarly journals Effects of erythritol on endothelial function in patients with type 2 diabetes mellitus: a pilot study

2013 ◽  
Author(s):  
Nir Flint ◽  
Naomi M. Hamburg ◽  
Monika Holbrook ◽  
Pamela G. Dorsey ◽  
Rebecca M. LeLeiko ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Pilot Study ◽  
Endothelial Function
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