scholarly journals Advanced Glycation Endproducts and Bone Material Strength in Type 2 Diabetes

2016 ◽  
Vol 101 (6) ◽  
pp. 2502-2510 ◽  
Author(s):  
Jessica R. Furst ◽  
Leonardo C. Bandeira ◽  
Wen-Wei Fan ◽  
Sanchita Agarwal ◽  
Kyle K. Nishiyama ◽  
...  
Keyword(s):  
Material Properties ◽  
Reference Point ◽  
Advanced Glycation Endproducts ◽  
Material Strength ◽  
Advanced Glycation ◽  
Bone Material ◽  
Glycation Endproducts ◽  
Reference Point Indentation ◽  
Bone Material Strength

Abstract Context: Skeletal deterioration, leading to an increased risk of fracture, is a known complication of type 2 diabetes mellitus (T2D). Yet plausible mechanisms to account for skeletal fragility in T2D have not been clearly established. Objective: The objective of the study was to determine whether bone material properties, as measured by reference point indentation, and advanced glycation endproducts (AGEs), as determined by skin autofluorescence (SAF), are related in patients with T2D. Design: This was a cross-sectional study. Setting: The study was conducted at a tertiary medical center. Patients: Sixteen postmenopausal women with T2D and 19 matched controls participated in the study. Main Outcome Measures: Bone material strength index (BMSi) by in vivo reference point indentation, AGE accumulation by SAF, and circulating bone turnover markers were measured. Results: BMSi was reduced by 9.2% in T2D (P = .02) and was inversely associated with the duration of T2D (r = −0.68, P = .004). Increased SAF was associated with reduced BMSi (r = −0.65, P = .006) and lower bone formation marker procollagen type 1 amino-terminal propeptide (r = −0.63, P = .01) in T2D, whereas no associations were seen in controls. SAF accounted for 26% of the age-adjusted variance in BMSi in T2D (P = .03). Conclusions: Bone material properties are impaired in postmenopausal women with T2D as determined by reference point indentation. The results suggest a role for the accumulation of AGEs to account for inferior BMSi in T2D.

scholarly journals SUN-LB68 Advanced Glycation Endproducts Are Associated With Worse Bone Material Strength in Older Adults With and Without Type 2 Diabetes

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Parinya Samakkarnthai ◽  
Jad G Sfeir ◽  
Elizabeth J Atkinson ◽  
Sara J Achenbach ◽  
Amanda J Tweed ◽  
...  
Keyword(s):  
Bone Quality ◽  
Advanced Glycation Endproducts ◽  
Material Strength ◽  
Advanced Glycation ◽  
Bone Material ◽  
Glycation Endproducts ◽  
Non Invasive ◽  
Bone Material Strength ◽  
And Control

Abstract Patients with Type 2 Diabetes (T2D) are at increased fracture risk despite having relatively normal or even increased BMD by DXA. The critical aspect of bone quality deterioration in T2D patients could explain this clinically important discrepancy. Material composition is a component of bone quality that has emerged as a potential factor contributing to fragility fractures in T2D patients. However, there is sparse evidence regarding whether T2D patients have decreased bone material properties compared with non-diabetic controls. We hypothesized that increased production of advanced glycation endproducts (AGEs) has an important role in reducing bone material strength in patients with and without diabetes. Thus, we used the OsteoProbe®, a bone microindentation device that provides an index of cortical bone material properties (Bone Material Strength index – BMSi) in men with T2D age ≥ 50 yrs or postmenopausal women with T2D and nondiabetic controls. We also utilized a non-invasive measure of skin AGEs (AGE Reader®) to evaluate AGEs accumulation through skin autofluorescence. Linear regression models were used to assess group differences with and without adjusting for age, Body Mass Index (BMI), and sex. Relationships between variables were assessed using adjusted Pearson correlations. A total of 152 T2D patients (mean age 68.5 ±7.6 yrs.; 59.2% men; HbA1C=7.7 ±1.0%; mean diabetes duration 15.5 yrs.) and 105 non-diabetic controls (mean age 67.2±8.8 yrs.; 41.0% men; HbA1C =5.4 ±0.3%) were recruited to the study. Overall, there was no difference in BMSi between T2DM and control subjects: unadjusted (p= 0.636); adjusted (p= 0.695). However, skin AGEs were negatively correlated with BMSi (r= -0.23, p <0.001). In subgroup analyses, skin AGEs were also negatively associated with BMSi in both T2DM (r= -0.23, p=0.004) and control (r= -0.21, p=0.033) subjects. In conclusion, these findings demonstrate that a higher burden of AGEs is associated with worse bone quality. Our findings may explain the conflicting findings regarding reductions in BMSi in T2D because only T2D patients with a high level of AGEs accumulation have impaired BMSi. Moreover, the association of skin AGEs with BMSi in non-diabetic subjects emphasizes the important role of AGEs in decreasing bone quality and potentially contributing to fracture risk. Collectively, our data indicate that non-invasive skin AGEs measurement could be used as a tool to evaluate bone quality in patients with T2D as well as in the non-diabetic population.

scholarly journals Correction: Advanced Glycation Endproducts and Bone Material Properties in Type 1 Diabetic Mice

PLoS ONE ◽  
2016 ◽  
Vol 11 (7) ◽  
pp. e0160164 ◽  
Author(s):  
Mishaela R. Rubin ◽  
Eleftherios P. Paschalis ◽  
Atharva Poundarik ◽  
Grazyna E. Sroga ◽  
Donald J. McMahon ◽  
...  
Keyword(s):  
Material Properties ◽  
Advanced Glycation Endproducts ◽  
Diabetic Mice ◽  
Advanced Glycation ◽  
Bone Material ◽  
Bone Material Properties ◽  
Glycation Endproducts

scholarly journals Applications of a New Handheld Reference Point Indentation Instrument Measuring Bone Material Strength

2013 ◽  
Vol 7 (4) ◽  
Author(s):  
Connor Randall ◽  
Daniel Bridges ◽  
Roberto Guerri ◽  
Xavier Nogues ◽  
Lluis Puig ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Soft Tissue ◽  
Reference Point ◽  
Material Strength ◽  
Bone Material ◽  
Reference Point Indentation ◽  
Instrument Measuring ◽  
Bone Material Strength ◽  
Large Animals

A novel, hand-held Reference Point Indentation (RPI) instrument, measures how well the bone of living patients and large animals resists indentation. The results presented here are reported in terms of Bone Material Strength, which is a normalized measure of how well the bone resists indentation, and is inversely related to the indentation distance into the bone. We present examples of the instrument's use in: (1) laboratory experiments on bone, including experiments through a layer of soft tissue, (2) three human clinical trials, two ongoing in Barcelona and at the Mayo Clinic, and one completed in Portland, OR, and (3) two ongoing horse clinical trials, one at Purdue University and another at Alamo Pintado Stables in California. The instrument is capable of measuring consistent values when testing through soft tissue such as skin and periosteum, and does so handheld, an improvement over previous Reference Point Indentation instruments. Measurements conducted on horses showed reproducible results when testing the horse through tissue or on bare bone. In the human clinical trials, reasonable and consistent values were obtained, suggesting the Osteoprobe® is capable of measuring Bone Material Strength in vivo, but larger studies are needed to determine the efficacy of the instrument's use in medical diagnosis.

scholarly journals Advanced Glycation Endproducts and Bone Material Properties in Type 1 Diabetic Mice

PLoS ONE ◽  
2016 ◽  
Vol 11 (5) ◽  
pp. e0154700 ◽  
Author(s):  
Mishaela R. Rubin ◽  
Eleftherios P. Paschalis ◽  
Atharva Poundarik ◽  
Gyna E. Sroga ◽  
Donald J. McMahon ◽  
...  
Keyword(s):  
Material Properties ◽  
Advanced Glycation Endproducts ◽  
Diabetic Mice ◽  
Advanced Glycation ◽  
Bone Material ◽  
Bone Material Properties ◽  
Glycation Endproducts

Bone material properties as measured by Reference Point Indentation are low in subjects with acromegaly

2016 ◽  
Author(s):  
Frank Malgo ◽  
Neveen A T Hamdy ◽  
Alberto M Pereira ◽  
Nienke R Biermasz ◽  
Natasha M Appelman-Dijkstra
Keyword(s):  
Material Properties ◽  
Reference Point ◽  
Bone Material ◽  
Bone Material Properties ◽  
Reference Point Indentation

scholarly journals Vitreous advanced glycation endproducts and α-dicarbonyls in retinal detachment patients with type 2 diabetes mellitus and non-diabetic controls

PLoS ONE ◽  
2017 ◽  
Vol 12 (3) ◽  
pp. e0173379 ◽  
Author(s):  
Bernardina T. Fokkens ◽  
Douwe J. Mulder ◽  
Casper G. Schalkwijk ◽  
Jean L. Scheijen ◽  
Andries J. Smit ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Retinal Detachment ◽  
Advanced Glycation Endproducts ◽  
Advanced Glycation ◽  
Glycation Endproducts
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