scholarly journals Incident Vertebral Fractures in Children With Leukemia During the Four Years Following Diagnosis

2015 ◽  
Vol 100 (9) ◽  
pp. 3408-3417 ◽  
Author(s):  
Elizabeth A. Cummings ◽  
Jinhui Ma ◽  
Conrad V. Fernandez ◽  
Jacqueline Halton ◽  
Nathalie Alos ◽  
...  
Keyword(s):  
Vertebral Fractures ◽  
Fractures In Children ◽  
Incident Vertebral Fractures

scholarly journals High Incidence of Vertebral Fractures in Children With Acute Lymphoblastic Leukemia 12 Months After the Initiation of Therapy

2012 ◽  
Vol 30 (22) ◽  
pp. 2760-2767 ◽  
Author(s):  
Nathalie Alos ◽  
Ronald M. Grant ◽  
Timothy Ramsay ◽  
Jacqueline Halton ◽  
Elizabeth A. Cummings ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Vertebral Fractures ◽  
Lymphoblastic Leukemia ◽  
Thoracolumbar Spine ◽  
Mineral Density ◽  
Fractures In Children ◽  
High Incidence ◽  
Z Scores ◽  
Initiation Of Therapy ◽  
Incident Vertebral Fractures

Purpose Vertebral fractures due to osteoporosis are a potential complication of childhood acute lymphoblastic leukemia (ALL). To date, the incidence of vertebral fractures during ALL treatment has not been reported. Patient and Methods We prospectively evaluated 155 children with ALL during the first 12 months of leukemia therapy. Lateral thoracolumbar spine radiographs were obtained at baseline and 12 months. Vertebral bodies were assessed for incident vertebral fractures using the Genant semiquantitative method, and relevant clinical indices such as spine bone mineral density (BMD), back pain, and the presence of vertebral fractures at baseline were analyzed for association with incident vertebral fractures. Results Of the 155 children, 25 (16%; 95% CI, 11% to 23%) had a total of 61 incident vertebral fractures, of which 32 (52%) were moderate or severe. Thirteen (52%) of the 25 children with incident vertebral fractures also had fractures at baseline. Vertebral fractures at baseline increased the odds of an incident fracture at 12 months by an odds ratio of 7.3 (95% CI, 2.3 to 23.1; P = .001). In addition, for every one standard deviation reduction in spine BMD Z-score at baseline, there was 1.8-fold increased odds of incident vertebral fracture at 12 months (95% CI, 1.2 to 2.7; P = .006). Conclusion Children with ALL have a high incidence of vertebral fractures after 12 months of chemotherapy, and the presence of vertebral fractures and reductions in spine BMD Z-scores at baseline are highly associated clinical features.

Assessment of a semi-automated software program for the identification of vertebral fractures in children

2017 ◽  
Author(s):  
Fawaz Alqahtani ◽  
Fabrizio Messina ◽  
Elzene Kruger ◽  
Heerunpal Gill ◽  
Michael Ellis ◽  
...  
Keyword(s):  
Vertebral Fractures ◽  
Fractures In Children ◽  
Software Program ◽  
Automated Software

Lumbar Vertebral Fractures in Children

2011 ◽  
Vol 27 (12) ◽  
pp. 1157-1162 ◽  
Author(s):  
Antonio E. Muñiz ◽  
Steven Liner
Keyword(s):  
Vertebral Fractures ◽  
Fractures In Children

Mild prevalent and incident vertebral fractures are risk factors for new fractures

2007 ◽  
Vol 18 (12) ◽  
pp. 1617-1624 ◽  
Author(s):  
C. Roux ◽  
J. Fechtenbaum ◽  
S. Kolta ◽  
K. Briot ◽  
M. Girard
Keyword(s):  
Risk Factors ◽  
Vertebral Fractures ◽  
Incident Vertebral Fractures

Incident vertebral fractures and mortality in older women: a prospective study

2003 ◽  
Vol 14 (7) ◽  
pp. 589-594 ◽  
Author(s):  
D. M. Kado ◽  
T. Duong ◽  
M. C. Nevitt ◽  
G. A. Greendale ◽  
S. R. Cummings ◽  
...  
Keyword(s):  
Prospective Study ◽  
Older Women ◽  
Vertebral Fractures ◽  
A Prospective Study ◽  
Incident Vertebral Fractures
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