scholarly journals Short Stature, Accelerated Bone Maturation, and Early Growth Cessation Due to Heterozygous Aggrecan Mutations

2014 ◽  
Vol 99 (8) ◽  
pp. E1510-E1518 ◽  
Author(s):  
Ola Nilsson ◽  
Michael H. Guo ◽  
Nancy Dunbar ◽  
Jadranka Popovic ◽  
Daniel Flynn ◽  
...  
Keyword(s):  
Short Stature ◽  
Early Growth ◽  
Bone Maturation ◽  
Growth Cessation ◽  
Accelerated Bone Maturation

scholarly journals Altered Sequence of Pubertal Changes and Accelerated Bone Maturation in A 10-Year-Old Japanese Boy with Nonendocrine Short Stature Treated with GH.

1994 ◽  
Vol 3 (Supple4) ◽  
pp. 125-127
Author(s):  
Seiji Sato ◽  
Makoto Anzo ◽  
Tsutomu Kamimaki ◽  
Maki Fukami ◽  
Nobutake Matsuo
Keyword(s):  
Short Stature ◽  
Bone Maturation ◽  
Old Japanese ◽  
Accelerated Bone Maturation

scholarly journals Effect of Growth Hormone Dose on Bone Maturation and Puberty in Children with Idiopathic Short Stature

2006 ◽  
Vol 91 (1) ◽  
pp. 169-175 ◽  
Author(s):  
Brenda J. Crowe ◽  
Lyset T. M. Rekers-Mombarg ◽  
Kristen Robling ◽  
Anne M. Wolka ◽  
Gordon B. Cutler ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Short Stature ◽  
Idiopathic Short Stature ◽  
Bone Maturation

scholarly journals Elucidation of Molecular and Hormonal Background of Early Growth Cessation and Endodormancy Induction in Two Contrasting Populus Hybrid Cultivars

2020 ◽  
Author(s):  
Ákos Boldizsár ◽  
Alexandra Soltész ◽  
Karen Tanino ◽  
Balázs Kalapos ◽  
Zsuzsa Marozsán-Tóth ◽  
...  
Keyword(s):  
Hybrid Poplar ◽  
Growth Cycle ◽  
Early Growth ◽  
Growth Cessation ◽  
Complex Interactions ◽  
Early Peak ◽  
Hybrid Cultivar ◽  
New Evidence ◽  
Kinetics Of ◽  
Delayed Growth

Abstract Background Over the life cycle of perennial trees, the dormant state enables the avoidance of abiotic stress conditions. The growth cycle can be partitioned into induction, maintenance and release and is controlled by complex interactions between many endogenous and environmental factors. While phytohormones have long been linked with dormancy, there is increasing evidence of regulation by DAM and CBF genes. To reveal whether the expression kinetics of CBFs and their target PtDAM1 is related to growth cessation and endodormancy induction in Populus, two hybrid poplar cultivars were studied.Results Growth cessation, dormancy status and expression of six PtCBFs and PtDAM1 were analyzed. The ‘Okanese’ hybrid cultivar ceased growth rapidly, was able to reach endodormancy, and exhibited a significant increase of several PtCBF transcripts in the buds on the 10th day. The ‘Walker’ cultivar had delayed growth cessation, was unable to enter endodormancy, and showed much lower CBF expression in buds. Expression of PtDAM1 peaked on the 10th day only in the buds of ‘Okanese’. Besides, in the leaves of the two cultivars, PtDAM1 was not expressed while the CBFs expression pattern was reversed. Leaf phytohormones in both cultivars followed similar profiles during growth cessation but differentiated based on cytokinins which were largely reduced, while the Ox-IAA and iP7G increased in ‘Okanese’ compared to ‘Walker’. Surprisingly, ABA concentration was reduced in leaves of both cultivars. However, the metabolic deactivation product of ABA, phaseic acid, exhibited an early peak on the first day in ‘Okanese’.Conclusions Our results indicate that PtCBFs and PtDAM1 have differential kinetics and spatial localization which may be related to early growth cessation and endodormancy induction under the regime of low night temperature and short photoperiod in poplar. Unlike buds, PtCBFs and PtDAM1 expression levels in leaves were not associated with early growth cessation and dormancy induction under these conditions. Our study provides new evidence that the degradation of auxin and cytokinins in leaves may be an important regulatory point in a CBF-DAM induced endodormancy. Further investigation of other PtDAMs in bud tissue and a study of both growth-inhibiting and the degradation of growth-promoting phytohormones is warranted.

scholarly journals Elucidation of molecular and hormonal background of early growth cessation and endodormancy induction in two contrasting Populus hybrid cultivars

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Ákos Boldizsár ◽  
Alexandra Soltész ◽  
Karen Tanino ◽  
Balázs Kalapos ◽  
Zsuzsa Marozsán-Tóth ◽  
...  
Keyword(s):  
Hybrid Poplar ◽  
Growth Cycle ◽  
Early Growth ◽  
Growth Cessation ◽  
Complex Interactions ◽  
Early Peak ◽  
Hybrid Cultivar ◽  
New Evidence ◽  
Kinetics Of ◽  
Delayed Growth

Abstract Background Over the life cycle of perennial trees, the dormant state enables the avoidance of abiotic stress conditions. The growth cycle can be partitioned into induction, maintenance and release and is controlled by complex interactions between many endogenous and environmental factors. While phytohormones have long been linked with dormancy, there is increasing evidence of regulation by DAM and CBF genes. To reveal whether the expression kinetics of CBFs and their target PtDAM1 is related to growth cessation and endodormancy induction in Populus, two hybrid poplar cultivars were studied which had known differential responses to dormancy inducing conditions. Results Growth cessation, dormancy status and expression of six PtCBFs and PtDAM1 were analyzed. The ‘Okanese’ hybrid cultivar ceased growth rapidly, was able to reach endodormancy, and exhibited a significant increase of several PtCBF transcripts in the buds on the 10th day. The ‘Walker’ cultivar had delayed growth cessation, was unable to enter endodormancy, and showed much lower CBF expression in buds. Expression of PtDAM1 peaked on the 10th day only in the buds of ‘Okanese’. In addition, PtDAM1 was not expressed in the leaves of either cultivar while leaf CBFs expression pattern was several fold higher in ‘Walker’, peaking at day 1. Leaf phytohormones in both cultivars followed similar profiles during growth cessation but differentiated based on cytokinins which were largely reduced, while the Ox-IAA and iP7G increased in ‘Okanese’ compared to ‘Walker’. Surprisingly, ABA concentration was reduced in leaves of both cultivars. However, the metabolic deactivation product of ABA, phaseic acid, exhibited an early peak on the first day in ‘Okanese’. Conclusions Our results indicate that PtCBFs and PtDAM1 have differential kinetics and spatial localization which may be related to early growth cessation and endodormancy induction under the regime of low night temperature and short photoperiod in poplar. Unlike buds, PtCBFs and PtDAM1 expression levels in leaves were not associated with early growth cessation and dormancy induction under these conditions. Our study provides new evidence that the degradation of auxin and cytokinins in leaves may be an important regulatory point in a CBF-DAM induced endodormancy. Further investigation of other PtDAMs in bud tissue and a study of both growth-inhibiting and the degradation of growth-promoting phytohormones is warranted.

scholarly journals Elucidation of molecular and hormonal background of early growth cessation and endodormancy induction in two contrasting Populus hybrid cultivars

2021 ◽  
Author(s):  
Ákos Boldizsár ◽  
Alexandra Soltész ◽  
Karen Tanino ◽  
Balázs Kalapos ◽  
Zsuzsa Marozsán-Tóth ◽  
...  
Keyword(s):  
Hybrid Poplar ◽  
Growth Cycle ◽  
Early Growth ◽  
Growth Cessation ◽  
Complex Interactions ◽  
Early Peak ◽  
Hybrid Cultivar ◽  
New Evidence ◽  
Kinetics Of ◽  
Delayed Growth

Abstract Background Over the life cycle of perennial trees, the dormant state enables the avoidance of abiotic stress conditions. The growth cycle can be partitioned into induction, maintenance and release and is controlled by complex interactions between many endogenous and environmental factors. While phytohormones have long been linked with dormancy, there is increasing evidence of regulation by DAM and CBF genes. To reveal whether the expression kinetics of CBFs and their target PtDAM1 is related to growth cessation and endodormancy induction in Populus, two hybrid poplar cultivars were studied which had known differential responses to dormancy inducing conditions.Results Growth cessation, dormancy status and expression of six PtCBFs and PtDAM1 were analyzed. The ‘Okanese’ hybrid cultivar ceased growth rapidly, was able to reach endodormancy, and exhibited a significant increase of several PtCBF transcripts in the buds on the 10th day. The ‘Walker’ cultivar had delayed growth cessation, was unable to enter endodormancy, and showed much lower CBF expression in buds. Expression of PtDAM1 peaked on the 10th day only in the buds of ‘Okanese’. In addition, PtDAM1 was not expressed in the leaves of either cultivar while leaf CBFs expression pattern was several fold higher in ‘Walker’, peaking at day 1. Leaf phytohormones in both cultivars followed similar profiles during growth cessation but differentiated based on cytokinins which were largely reduced, while the Ox-IAA and iP7G increased in ‘Okanese’ compared to ‘Walker’. Surprisingly, ABA concentration was reduced in leaves of both cultivars. However, the metabolic deactivation product of ABA, phaseic acid, exhibited an early peak on the first day in ‘Okanese’.Conclusions Our results indicate that PtCBFs and PtDAM1 have differential kinetics and spatial localization which may be related to early growth cessation and endodormancy induction under the regime of low night temperature and short photoperiod in poplar. Unlike buds, PtCBFs and PtDAM1 expression levels in leaves were not associated with early growth cessation and dormancy induction under these conditions. Our study provides new evidence that the degradation of auxin and cytokinins in leaves may be an important regulatory point in a CBF-DAM induced endodormancy. Further investigation of other PtDAMs in bud tissue and a study of both growth-inhibiting and the degradation of growth-promoting phytohormones is warranted.

scholarly journals High-dose GH treatment limited to the prepubertal period in young children with idiopathic short stature does not increase adult height

2010 ◽  
Vol 162 (4) ◽  
pp. 653-660 ◽  
Author(s):  
S A van Gool ◽  
G A Kamp ◽  
R J Odink ◽  
S M P F de Muinck Keizer-Schrama ◽  
H A Delemarre-van de Waal ◽  
...  
Keyword(s):  
Short Stature ◽  
Adult Height ◽  
Treated Group ◽  
Idiopathic Short Stature ◽  
High Dose ◽  
Bone Maturation ◽  
Gh Treatment ◽  
Height Gain ◽  
Design And Methods ◽  
And Control

ObjectiveTo assess the long-term effect of prepubertal high-dose GH treatment on growth in children with idiopathic short stature (ISS).Design and methodsForty children with no signs of puberty, age at start 4–8 years (girls) or 4–10 years (boys), height SDS <−2.0 SDS, and birth length >−2.0 SDS, were randomly allocated to receive GH at a dose of 2 mg/m2 per day (equivalent to 75 μg/kg per day at start and 64 μg/kg per day at stop) until the onset of puberty for at least 2 years (preceded by two 3-month periods of treatment with low or intermediate doses of GH separated by two washout periods of 3 months) or no treatment. In 28 cases, adult height (AH) was assessed at a mean (s.d.) age of 20.4 (2.3) years.ResultsGH-treated children (mean treatment period on high-dose GH 2.3 years (range 1.2–5.0 years)) showed an increased mean height SDS at discontinuation of the treatment compared with the controls (−1.3 (0.8) SDS versus −2.6 (0.8) SDS respectively). However, bone maturation was significantly accelerated in the GH-treated group compared with the controls (1.6 (0.4) versus 1.0 (0.2) years per year, respectively), and pubertal onset tended to advance. After an untreated interval of 3–12 years, AH was −2.1 (0.7) and −1.9 (0.6) in the GH-treated and control groups respectively. Age was a positive predictor of adult height gain.ConclusionHigh-dose GH treatment restricted to the prepubertal period in young ISS children augments height gain during treatment, but accelerates bone maturation, resulting in a similar adult height compared with the untreated controls.

scholarly journals Nonclassic congenital adrenal hyperplasia resulting from 21-hydroxylase deficiency

2004 ◽  
Vol 132 (suppl. 1) ◽  
pp. 106-108
Author(s):  
Maja Jesic ◽  
Milos Jesic ◽  
Silvija Sajic ◽  
Svjetlana Maglajlic ◽  
Svetislav Necic ◽  
...  
Keyword(s):  
Late Onset ◽  
Hydroxylase Deficiency ◽  
Bone Maturation ◽  
Hormone Synthesis ◽  
Constant Control ◽  
Mild Deficiency ◽  
One Year ◽  
21 Hydroxylase Deficiency ◽  
Accelerated Bone Maturation ◽  
Premature Pubarche

Nonclassic CAH, also termed as late onset of CAH, is a very mild form of 21-hydroxylase deficiency. The incidence of disease is estimated at 0.1% of population. Nonclassic CAH is usually diagnosed in the childhood before the age of 6 to 8 years as premature pubarche. The disease is not common in the infants and usually not before 6 to 8 months. This is a case report of 7-month female infant who was suspected of mild hyperandrogenism because of premature pubarche. The diagnosis was confirmed by mild basal elevation of 17-OHP (5.55 ng/ml) and characteristic hyper-response to ACTH, reaching values of 21 ng/ml, as well as accelerated bone maturation. The conventional treatment of NCAH was initiated, with glucocorticoid therapy (hydrocortisone) for one year and a half. After that period, our decision was to discontinue the hormonal therapy because of the impression that hyperandrogenism was mild (mild deficiency of the enzymes for steroid hormone synthesis). Child?s growth, development and maturation are under constant control.

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