scholarly journals Impact of Month of Birth on the Development of Autoimmune Thyroid Disease in the United Kingdom and Europe

2014 ◽  
Vol 99 (8) ◽  
pp. E1459-E1465 ◽  
Author(s):  
Alexander Hamilton ◽  
Paul R. Newby ◽  
Jacqueline D. Carr-Smith ◽  
Giulio Disanto ◽  
Amit Allahabadia ◽  
...  
Keyword(s):  
United Kingdom ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Month Of Birth ◽  
Autoimmune Thyroid ◽  
The United Kingdom

scholarly journals Impact of Month of Birth on the Risk of Development of Autoimmune Addison’s Disease

2016 ◽  
Vol 101 (11) ◽  
pp. 4214-4218 ◽  
Author(s):  
Agnieszka Pazderska ◽  
Marta Fichna ◽  
Anna L. Mitchell ◽  
Catherine M. Napier ◽  
Earn Gan ◽  
...  
Keyword(s):  
United Kingdom ◽  
General Population ◽  
Addison’S Disease ◽  
Addison's Disease ◽  
Distribution Analysis ◽  
Month Of Birth ◽  
Ratio Distribution ◽  
Autoimmune Thyroid ◽  
The United Kingdom ◽  
Increased Risk

Context: The pathogenesis of autoimmune Addison’s disease (AAD) is thought to be due to interplay of genetic, immune, and environmental factors. A month-of-birth effect, with increased risk for those born in autumn/winter months, has been described in autoimmune conditions such as type 1 diabetes and autoimmune thyroid disease. Objective: Month-of-birth effect was investigated in 2 independent cohorts of AAD subjects. Design, Setting, and Patients: The monthly distribution of birth in AAD patients was compared with that of the general population using the cosinor test. A total of 415 AAD subjects from the United Kingdom cohort were compared with 8 180 180 United Kingdom births, and 231 AAD subjects from the Polish cohort were compared with 2 421 384 Polish births. Main Outcome Measures: Association between month of birth and the susceptibility to AAD. Results: In the entire cohort of AAD subjects, month-of-birth distribution analysis showed significant periodicity with peak of births in December and trough in May (P = .028). Analysis of the odds ratio distribution based on month of birth in 2 cohorts of patients with AAD versus the general population revealed a December peak and May trough, and January peak and July trough, in the United Kingdom and Polish cohorts, respectively. Conclusion: For the first time, we demonstrate that month of birth exerts an effect on the risk of developing AAD, with excess risk in individuals born in winter months and a protective effect when born in the summer. Exposure to seasonal viral infections in the perinatal period, coupled with vitamin D deficiency, could lead to dysregulation of innate immunity affecting the risk of developing AAD.

Besondere Manifestationsformen der Autoimmunthyreopathie

Praxis ◽  
2002 ◽  
Vol 91 (27) ◽  
pp. 1151-1160
Author(s):  
Fajfr ◽  
Müller
Keyword(s):  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Chromosome 6 ◽  
Autoimmune Thyroid

Les maladies thyroïdiennes auto-immunes ou immunes (autoimmune thyroid disease, AITD) sont relativement fréquentes. Le terme de AITD comprend les thyréodites euthyroidiennes ou hypothyroïdiennes de Hashimoto avec ou sans goitre, les hyperthyroïdies classiques de Basedow et leurs variantes nettement plus rares euthyroïdiennes ou hypothyroïdiennes. Aucune des nombreuses classifications des AITD n'a pu s'imposer sur le plan international. La pathogénèse de toutes les formes d'AITD comprend une perturbation de la tolérance immune chez les individus prédisposés génétiquement (séquence HLA-DQAI*0501 sur le bras court du chromosome 6) qui provoque un processus auto-immun contre la glande thyroïdienne. Ces processus sont soit destructeurs ou inhibiteurs, soit stimulateurs, ce qui permet d'expliquer les formes très différentes de AITD. Dans de cas rares, ces processus peuvent se contrebalancer («balance hypotheseis»). Les anticorps anti-récepteurs TPO et TSH (TRAK) ont une place particulière dans le diagnostic des AITD. Les dosages de routine utilisent pour la mesure des TRAK des récepteurs qui ne peuvent pas différencier entre les anticorps stimulants ou bloquants contre les récepteurs TSH. C'est, entre autre pour ces raisons, que les résultats d'anticorps positifs ne sont utilisables qu'en connaissance de la clinique et / ou des paramètres de la fonction thyroïdienne. Ce travail présente quatre patients avec des formes plus complexes d'AITD et résume les connaissances actuelles.

Sarcoidosis and autoimmune thyroid disease

Pneumologie ◽  
2012 ◽  
Vol 66 (11) ◽  
Author(s):  
C Ravaglia ◽  
C Gurioli ◽  
M Romagnoli ◽  
G Casoni ◽  
S Tomassetti ◽  
...  
Keyword(s):  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Autoimmune Thyroid

Autoimmune thyroid disease, genetic predisposition and environment – case-control and family studies

2007 ◽  
Vol 115 (S 1) ◽  
Author(s):  
M Meilinger ◽  
N Schweighofer ◽  
A Forjanics ◽  
H Dobnig ◽  
A Fahrleitner-Pammer ◽  
...  
Keyword(s):  
Genetic Predisposition ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Family Studies ◽  
Case Control ◽  
Autoimmune Thyroid

Autoimmune thyroid disease may affect prognosis of breast cancer

2017 ◽  
Author(s):  
Selim Yalcin ◽  
Ramazan Cosar ◽  
Aydin Cifci ◽  
Askin Gungunes ◽  
Senay Arikan Durmaz
Keyword(s):  
Breast Cancer ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Autoimmune Thyroid
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