scholarly journals The Role of Vitamin D Receptor in Innate and Adaptive Immunity: A Study in Hereditary Vitamin D–Resistant Rickets Patients

2013 ◽  
Vol 98 (4) ◽  
pp. 1685-1693 ◽  
Author(s):  
Dov Tiosano ◽  
Gizi Wildbaum ◽  
Vardit Gepstein ◽  
Oleg Verbitsky ◽  
Yosef Weisman ◽  
...  
Keyword(s):  
Vitamin D ◽  
Adaptive Immunity ◽  
Vitamin D Receptor ◽  
Innate And Adaptive Immunity ◽  
Vitamin D Resistant Rickets ◽  
Resistant Rickets

A homozygous mutation in the DNA binding domain of human vitamin D receptor causes vitamin D resistant rickets

Bone ◽  
2012 ◽  
Vol 50 ◽  
pp. S43
Author(s):  
B.C. van der Eerden⁎ ◽  
J.C. van der Heyden ◽  
J.P. van Hamburg ◽  
M. Schreuders-Koedam ◽  
P.S. Asmawidjaja ◽  
...  
Keyword(s):  
Vitamin D ◽  
Dna Binding ◽  
Vitamin D Receptor ◽  
Binding Domain ◽  
Homozygous Mutation ◽  
Dna Binding Domain ◽  
Vitamin D Resistant Rickets ◽  
Resistant Rickets

scholarly journals Self-Care for Common Colds: The Pivotal Role of Vitamin D, Vitamin C, Zinc, and Echinacea in Three Main Immune Interactive Clusters (Physical Barriers, Innate and Adaptive Immunity) Involved during an Episode of Common Colds—Practical Advice on Dosages and on the Time to Take These Nutrients/Botanicals in order to Prevent or Treat Common Colds

2018 ◽  
Vol 2018 ◽  
pp. 1-36 ◽  
Author(s):  
Mariangela Rondanelli ◽  
Alessandra Miccono ◽  
Silvia Lamburghini ◽  
Ilaria Avanzato ◽  
Antonella Riva ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin C ◽  
Adaptive Immunity ◽  
Prophylactic Treatment ◽  
Immune Defense ◽  
Current Evidence ◽  
Innate And Adaptive Immunity ◽  
Physical Barriers ◽  
Preventive Role

Maintaining a normal healthy immune defense system lowers the incidence and/or the severity of symptoms and/or the duration of common cold (CC). Physical barriers and innate and adaptive immunity have been involved during a CC episode. Vitamins C and D, zinc, and Echinacea have evidence-based efficacy on these immune system barriers. This review includes 82 eligible studies to consider the preventive role of these nutrients in immune clusters and in CC to provide advice on dosage and assumption of these nutrients. Regarding vitamin C, regular supplementation (1 to 2 g/day) has shown that vitamin C reduces the duration (in adults by 8%, in children by 14%) and the severity of CC. Considering zinc, the supplementation may shorten the duration of colds by approximately 33%. CC patients may be instructed to try zinc within 24 hours of onset of symptoms. As for vitamin D, the supplementation protected against CC overall, considering baseline levels and age. Patients with vitamin D deficiency and those not receiving bolus doses experienced the most benefit. Regarding Echinacea, prophylactic treatment with this extract (2400 mg/day) over 4 months appeared to be beneficial for preventing/treating CC. In conclusion, the current evidence of efficacy for zinc, vitamins D and C, and Echinacea is so interesting that CC patients may be encouraged to try them for preventing/treating their colds, although further studies are needed on this topic.

The role of IGF-I in phosphate therapy for the short stature of patients with hypophosphatemic vitamin D-resistant rickets

1996 ◽  
Vol 14 (4) ◽  
pp. 222-228 ◽  
Author(s):  
Takehisa Yamamoto ◽  
Keiichi Ozono ◽  
Kanji Yamaoka ◽  
Masaaki Shima ◽  
Katsusuke Yamamoto ◽  
...  
Keyword(s):  
Vitamin D ◽  
Short Stature ◽  
Igf I ◽  
Vitamin D Resistant Rickets ◽  
Resistant Rickets

Hereditary vitamin D-resistant rickets in Lebanese patients: the p.R391S and p.H397P variants have different phenotypes

2017 ◽  
Vol 30 (4) ◽  
Author(s):  
Rabih Andary ◽  
Abdul-Karim El-Hage-Sleiman ◽  
Theresa Farhat ◽  
Sami Sanjad ◽  
Georges Nemer
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Sanger Sequencing ◽  
Autosomal Recessive ◽  
Autosomal Recessive Disorder ◽  
Normal Phenotype ◽  
Vitamin D Resistant Rickets ◽  
Exon 9 ◽  
Homozygous Mutations ◽  
Resistant Rickets

Abstract:Background:Hereditary vitamin D-resistant rickets (HVDRR) is an autosomal recessive disorder caused by mutations in the vitamin D receptor (Methods:We examined four patients with HVDRR from three unrelated Lebanese families. All parents were consanguineous with normal phenotype. We used Sanger sequencing to identify mutations in the coding exons ofResults:Two homozygous mutations (p.R391S and p.H397P), both in exon 9 of theConclusions:This is the first report of

Sign in / Sign up

Export Citation Format

Share Document