scholarly journals The Natural History of Subclinical Hypothyroidism in the Elderly: The Cardiovascular Health Study

2012 ◽  
Vol 97 (6) ◽  
pp. 1962-1969 ◽  
Author(s):  
Lily L. Somwaru ◽  
Chevon M. Rariy ◽  
Alice M. Arnold ◽  
Anne R. Cappola
Keyword(s):  
Natural History ◽  
Subclinical Hypothyroidism ◽  
Cardiovascular Health ◽  
The Elderly ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
History Of

scholarly journals Subclinical Hypothyroidism, Weight Change, and Body Composition in the Elderly: The Cardiovascular Health Study

2014 ◽  
Vol 99 (4) ◽  
pp. 1220-1226 ◽  
Author(s):  
Margaret C. Garin ◽  
Alice M. Arnold ◽  
Jennifer S. Lee ◽  
Russell P. Tracy ◽  
Anne R. Cappola
Keyword(s):  
Body Composition ◽  
Weight Change ◽  
Subclinical Hypothyroidism ◽  
Cardiovascular Health ◽  
The Elderly ◽  
Health Study ◽  
Cardiovascular Health Study

scholarly journals Persistent Subclinical Hypothyroidism and Cardiovascular Risk in the Elderly: The Cardiovascular Health Study

2013 ◽  
Vol 98 (2) ◽  
pp. 533-540 ◽  
Author(s):  
Kristen A. Hyland ◽  
Alice M. Arnold ◽  
Jennifer S. Lee ◽  
Anne R. Cappola
Keyword(s):  
Older Adults ◽  
Thyroid Function ◽  
Subclinical Hypothyroidism ◽  
Cardiovascular Health ◽  
The Elderly ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Thyroid Function Tests ◽  
Function Tests ◽  
Increased Risk

Abstract Context: Use of a single set of thyroid function tests to define subclinical hypothyroidism may lead to misclassification over time and could influence findings from longitudinal studies. Objective: We assessed the risks of coronary heart disease (CHD), heart failure (HF), and cardiovascular (CV) death in older adults with persistent subclinical hypothyroidism. Design, Setting, and Participants: The study included 679 subclinically hypothyroid and 4184 euthyroid U.S. individuals at least 65 yr old enrolled in the Cardiovascular Health Study and not taking thyroid preparations. Main Outcome Measure: We measured the 10-yr risk of incident CHD, HF, and CV death from persistent subclinical hypothyroidism, overall and stratified by degree of TSH elevation (4.5–6.9, 7.0–9.9, and 10.0–19.9 mU/liter). Results: There was no association between persistent subclinical hypothyroidism and incident CHD [hazard ratio (HR), 1.12; 95% confidence interval (CI), 0.93–1.36], HF (HR, 1.05; 95% CI, 0.97–1.27), or CV death (HR, 1.07; 95% CI, 0.87–1.31) in adjusted analyses in which subclinical hypothyroidism was modeled as a time-varying exposure using up to four serial thyroid function tests. When subclinical hypothyroidism was stratified by degree of TSH elevation, no significant associations were found in any stratum. Findings were similar in fixed exposure analyses in which only participants with testing 2 yr apart were considered, with no association between persistent or transient subclinical hypothyroidism and incident CHD, HF, or CV death. Conclusions: Our data do not support increased risk of CHD, HF, or CV death in older adults with persistent subclinical hypothyroidism.

scholarly journals Silent Brain MRI Infarcts and Subsequent Stroke Type In the Cardiovascular health Study

Stroke ◽  
2001 ◽  
Vol 32 (suppl_1) ◽  
pp. 363-363
Author(s):  
Charles B Bernick ◽  
Lewis H Kuller ◽  
Will T Longstreth ◽  
Corinne Dulberg ◽  
Teri A Manolio ◽  
...  
Keyword(s):  
Hemorrhagic Stroke ◽  
Cardiovascular Health ◽  
Brain Mri ◽  
The Elderly ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Prior History ◽  
Mri Scans ◽  
Cranial Mri ◽  
Silent Mri

P136 Objective: Silent infarcts seen on cranial MRI scans are a risk factor for subsequent clinical stroke in the elderly. This study examines the type of clinical strokes seen in those with silent infarcts. Methods: Cranial MRI examination was completed on 3324 Cardiovascular Health Study (CHS) participants aged 65+ who were without a prior history of clinical stroke. Incident strokes were identified over an average follow-up of 4 years and classified as hemorrhagic or ischemic. Ischemic strokes were further subdivided into lacunar, cardioembolic, atherosclerotic or other/unknown. Results: Silent MRI infarcts >3mm were found in approximately 28% (n=923). Of these, 7% (n=67) subsequently had a clinically evident stroke. The characteristics of the silent MRI infarcts in those who sustained an incident stroke were as folows: 56 had only subcortical infarcts, of which 55 were <20mm; 4 had only cortical infarcts; and 7 had both cortical and subcortical infarcts. Of those with only subcortical silent MRI infarcts, 16% (n=9) went on to a hemorrhagic stroke and 84% (n=47) sustained an ischemic stroke. The ischemic strokes were subtyped as 12 cardioembolic, 3 lacunar, 2 atherosclerotic and 30 unknown/other. Considering only those with cortical silent infarcts, either alone or in combination with subcortical infarcts, there was 1 hemorrhagic stroke and 10 ischemic strokes. Half of the ischemic strokes were cardioembolic and half were unknown type. Conclusion: Elderly individuals with silent subcortical infarcts who go onto subsequent stroke may be at risk not only for lacunar infarcts but also cardioembolic or hemorrhagic strokes.

Factor V Leiden Is not a Risk Factor for Arterial Vascular Disease in the Elderly: Results from the Cardiovascular Health Study

1998 ◽  
Vol 79 (05) ◽  
pp. 912-915 ◽  
Author(s):  
Mary Cushman ◽  
Frits R. Rosendaal ◽  
Bruce M. Psaty ◽  
E. Francis Cook ◽  
J. Valliere ◽  
...  
Keyword(s):  
Risk Factor ◽  
Arterial Thrombosis ◽  
Cardiovascular Health ◽  
Factor V Leiden ◽  
Coagulation Factor ◽  
The Elderly ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Factor V ◽  
Incident Cases

SummaryCoagulation factor V Leiden is a risk marker for venous thrombosis. For arterial thrombosis no large study to date has included population-based elderly patients. The Cardiovascular Health Study is a longitudinal study of 5,201 men and women over age 65. With 3.4-year follow-up, we studied 373 incident cases of myocardial infarction (MI), angina, stroke, or transient ischemic attack (TIA), and 482 controls. The odds ratios for each event with heterozygous factor V Leiden were: MI, 0.46 (95% CI 0.17 to 1.25); angina, 1.0 (95% CI 0.45 to 2.23); stroke, 0.77 (95% CI 0.35 to 1.70); TIA, 1.33 (95% CI 0.5 to 3.55); any outcome, 0.83 (95% CI 0.48 to 1.44). Adjustment for cardiovascular risk factors did not change relationships. In older adults factor V Leiden is not a risk factor for future arterial thrombosis.

scholarly journals Association of Serum Uromodulin With ESKD and Kidney Function Decline in the Elderly: The Cardiovascular Health Study

2019 ◽  
Vol 74 (4) ◽  
pp. 501-509 ◽  
Author(s):  
Dominik Steubl ◽  
Petra Buzkova ◽  
Pranav S. Garimella ◽  
Joachim H. Ix ◽  
Prasad Devarajan ◽  
...  
Keyword(s):  
Kidney Function ◽  
Cardiovascular Health ◽  
The Elderly ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Kidney Function Decline
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